Clinical significance of activity of ALT enzyme in patients with hepatitis C virus

Akkaya, Onder; Kıyıcı, Murat; Yılmaz, Yusuf; Ulukaya, Engin; Yerci, Ömer

doi:10.3748/wjg.v13.i41.5481

Cited by 34 publications

(34 citation statements)

References 26 publications

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“…Bu parametreler ile hastalık aktivitesinin değerlendirilmesi klinik araştırma-ların ana konularından birisi haline gelmiştir (5) . Kronik C hepatitli hastalarda viral yükün kantitatif değerleri ile karaciğer histolojisi ilişkisini araştıran çalışmalar yapılmıştır (2,9,15,20) . Çalışma-mızda HCV RNA viral yük ile histolojik aktivite indeksi ve fibrozis skoru arasında anlamlı bir ilişki bulunmamıştır.…”

Section: Discussionunclassified

“…Literatürde ALT yük-sekliği ile HCV-RNA viral yük arasındaki ilişki-yi araştıran çalışmalarda alınan sonuçlar farklı-dır. Bu çalışmaların çoğunluğunda korelasyon bulunamazken (5,6,14) , negatif korelasyon bulan çalışma (2) , pozitif korelasyon bulan çalışma da vardır (8) . Bizim çalışmamızda serum ALT değer-leri ile HCV RNA viral yük ve steatoz arasında istatistiksel anlamlı bir ilişki bulunamamıştır.…”

Section: Discussionunclassified

“…Akkaya ve ark. (2) serum ALT yüksekliği ile periportal köp-rüleşme/nekrozis arasında pozitif bir ilişki olduğunu bildirmişlerdir. Özkara ve ark.…”

Section: Discussionunclassified

“…Bu sonuçlar Akkaya ve ark. (2) , Özkara ve ark. (18) çalışmalarında buldukları sonuçları desteklemektedir.…”

Section: Discussionunclassified

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The Comparison of Serum HCV-RNA Levels and Histopathological Features of Patients with Chronic Hepatitis C Infection

Kirişçi¹,

ROTA²,

Cengiz³

et al. 2014

Ankem Derg

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ÖZET Hepatit C virüsü (HCV); uzun yıllar non-A, non-B hepatiti olarak bilinmiş SUMMARY The Comparison of Serum HCV-RNA Levels and Histopathological Features of Patients with Chronic Hepatitis C Infection Hepatitis C virus (HCV), formerly known as non A-non B hepatitis, was also described as posttransfusion hepatitis as a separate clinical entity in 1975 because it was frequently reported in patients who received blood transfusions. The aims of this study are to evaluate the relationship between the serum levels of HCV RNA and alanine aminotransferase (ALT) with steatosis,histologic activity index and fibrosis in liver and the same time to research the condition of fibrosis and steatosis in chronic hepatitis

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Section: Discussionunclassified

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The Comparison of Serum HCV-RNA Levels and Histopathological Features of Patients with Chronic Hepatitis C Infection

Kirişçi¹,

ROTA²,

Cengiz³

et al. 2014

Ankem Derg

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show abstract

“…The duration and route of transmission of the disease, viral genotype, viral load, alcohol abuse and co-infection with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) are among the factors affecting the progression of the disease (5,9). Chronic hepatitis B (CHB) is usually indolent and incidentally recognized during routine serological tests, blood biochemistry tests or histological tests (5,15). The diagnosis of HCV infection is established by detecting antibody formed against the virus (anti-HCV) and by measuring HCV RNA by nucleic acid amplification method (1).…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between the Serum RNA Titers of Hepatitis C Virus and Biochemical Parameters in Chronic Hepatitis C Patients

Nar¹,

Sezgin²

2016

vhd

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ÖZObjective: Liver biopsy, as well as some non-invasive biochemical parameters are also used in monitoring patients with chronic hepatitis C (CHC). The aim of this study was to investigate the relationship between serum biochemical markers and HCV RNA titers in patients with previously untreated CHC. Materials and Methods:We performed a retrospective study on anti-HCV and HCV-RNA-positive 82 patients with CHC. Eighty two healthy subjects constituted the control group. Complete blood counts, total protein (TP), albumin (ALB), C-reactive protein (CRP), γ-glutamyl transpeptidase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and HCV RNA levels were recorded for each patient and control subject. Neutrophil-lymphocytes ratio (NLR) and the fibrosis index based on the 4 factors (FIB-4 index) were calculated using formulas.Results: There was a significant difference in ALT, AST, GGT, TP , CRP , red cell distribution width (RDW), lymphocytes (LYM), platelets (PLT), FIB-4, and NLR between CHC patients and controls (p=<0.05

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Serum level of interleukin-10 with its gene polymorphism can be predictors of response to treatment in Egyptian patients with chronic hepatitis C virus

Bassat

Ali

El-Din

et al. 2013

Egyptian Journal of Medical Human Genetics

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Clinical significance of activity of ALT enzyme in patients with hepatitis C virus

Abstract: In patients with HCV, alterations in the liver tissue as reflected by ALT elevation are mainly associated with periportal bridging/necrosis, viral load and duration of disease. A cut-off value < 23 IU/L distinguished with high diagnostic accuracy healthy controls from patients with HCV.

Cited by 34 publications

References 26 publications

The Comparison of Serum HCV-RNA Levels and Histopathological Features of Patients with Chronic Hepatitis C Infection

The Comparison of Serum HCV-RNA Levels and Histopathological Features of Patients with Chronic Hepatitis C Infection

The Relationship Between the Serum RNA Titers of Hepatitis C Virus and Biochemical Parameters in Chronic Hepatitis C Patients

Serum level of interleukin-10 with its gene polymorphism can be predictors of response to treatment in Egyptian patients with chronic hepatitis C virus

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