Clinical Significance of Atypical Glandular Cells by the 2001 Bethesda System in Cytohistologic Correlation

Lai, Chiung Ru; Hsu, Christine D.; Tsay, Shyh Haw; Li, Anna Fen Yau

doi:10.1159/000325598

Cited by 28 publications

(29 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the development of the 2001 Bethesda System [10], cytopathologists and cytotechnologists became more familiar with the cytomorphological features of endometrial cancers. Beside our previous reports [5,6,7], some other papers reporting liquid-based preparations [11,12,13] have revealed improved sensitivity in recent years. Similar to the results of Zhou et al [13], we found that abnormal cells tend to be present more often in patients with type II cancers, a higher grade/stage and cervical involvement.…”

Section: Discussionmentioning

confidence: 79%

“…Based on our previous observations [5,6,7], our screeners were been trained to screen for the possibility of endometrial lesions in addition to cervical lesions by 2010. Cytomorphology, including the maturation pattern and the presence of degenerative endometrial debris, foamy histiocytes with phagocytosis and abnormal endometrial cells, was considered an important hint for endometrial pathology (fig.…”

Section: Methodsmentioning

confidence: 99%

“…In the past, the Pap smear was thought to be unreliable in the detection of endometrial lesions [4]. However, some recent studies, including ours, demonstrate significant associations between endometrial pathology and atypical endometrial glandular cells, shedding endometrial debris and foamy histiocytes [5,6,7,8,9]. By incorporating these criteria into routine cervical cancer screening, we tried to evaluate whether Pap smears were also effective in detecting endometrial lesions.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Diagnostic Value of Routine Papanicolaou Smears for Detecting Endometrial Cancers: An Update

et al. 2015

Self Cite

View full text Add to dashboard Cite

Objective: The presence of degenerative endometrial debris and abnormal endometrial cells is considered to be the hint for endometrial pathology. The purpose of this study was to evaluate the efficacy of Papanicolaou (Pap) smears in detecting endometrial cancers. Study Design: There were 146 cases of endometrial cancer diagnosed at our institute in 2000-2002 and 271 in 2010-2012. Among them, 57 and 95 relevant reports of Pap smears 6 months prior to the histology diagnosis were retrieved for this study, respectively. In the first time period, new criteria for detecting endometrial lesions had not yet been incorporated into routine screening. Results: Twenty cases (21%) of adenocarcinoma, 12 (13%) of atypical glandular cells, 4 (4%) of endometrial debris and 59 (62%) negative reports were found among the more recent 95 relevant Pap smears. The overall efficacy of the Pap smear for detecting endometrial malignancy was 38%, higher than 10 years previously (30%). Conclusion: Although the Pap smear was originally designed to screen cervical lesions, more effective detection of endometrial lesions could be achieved by adding new criteria to the routine screening.

show abstract

Section: Discussionmentioning

confidence: 79%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Diagnostic Value of Routine Papanicolaou Smears for Detecting Endometrial Cancers: An Update

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…On the other hand, Lai et al . reported that malignant lesions were detected in all 7 patients with AGC-FN (11). Thus, the detection rates of malignant or premalignant lesions ranged from 15% to 43% for AGC-NOS, whereas the corresponding range was 41%–100% for AGC-FN.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Atypical Glandular Cells in the Bethesda System 2001: A Comparison with the Histopathological Diagnosis of Surgically Resected Specimens

Shoji¹,

Takatori²,

Takeuchi³

et al. 2014

Cancer Investigation

View full text Add to dashboard Cite

Forty-one patients diagnosed with atypical glangular cells (AGC) underwent surgery, and the histopathological diagnosis results for the resected specimens and the clinical features were analyzed. Out of 41 patients, final pathological diagnosis was endometrial cancer in 13 patients, cervical adenocarcinoma in 8, AIS in 7, CIN3 in 6, others in 2, and no lesions in 5. In comparison with previous reports, malignant or premalignant lesions were detected more frequently in patients with AGC who underwent surgery. We believe that conization or hysterectomy aimed at diagnosis and treatment, as well as endometrial histodiagnosis, should be carried out aggressively in patients with AGC.

show abstract

“…[3][4][5][6][7][8] However, most were relatively small in sample size, with most having approximately 100 -200 women with AGC cytology [3][4][5][6][7][8] and the largest having 662 cases, 9 but did not include high-risk HPV testing. A recent literature review suggested that HPV DNA testing may be useful in differentiated the risk of cervical and endometrial cancer, 10 based on a total of 661 women with AGC cytology and HPV DNA testing.…”

mentioning

confidence: 99%

Relationship of Atypical Glandular Cell Cytology, Age, and Human Papillomavirus Detection to Cervical and Endometrial Cancer Risks

Castle

Fetterman

Poitras

et al. 2010

Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

show abstract

Clinical Significance of Atypical Glandular Cells by the 2001 Bethesda System in Cytohistologic Correlation

Cited by 28 publications

References 22 publications

The Diagnostic Value of Routine Papanicolaou Smears for Detecting Endometrial Cancers: An Update

The Diagnostic Value of Routine Papanicolaou Smears for Detecting Endometrial Cancers: An Update

Clinical Significance of Atypical Glandular Cells in the Bethesda System 2001: A Comparison with the Histopathological Diagnosis of Surgically Resected Specimens

Relationship of Atypical Glandular Cell Cytology, Age, and Human Papillomavirus Detection to Cervical and Endometrial Cancer Risks

Contact Info

Product

Resources

About