Clinical significance of c-myc and p53 expression in head and neck squamous cell carcinomas

Waitzberg, Ângela Flávia Logullo; Nonogaki, Suely; Nishimoto, Inês Nobuko; Kowalski, Luiz Paulo; Miguel, Roberto Elias Villela; Brentani, Ricardo R.; Brentani, Maria Mitzi

doi:10.1016/j.cdp.2004.02.003

Cited by 30 publications

(27 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prognostic significance of p53 alterations in OSCC/OPSCC is inconsistent [13]. Consistent with some others [14][15][16][17], the current study revealed a nonsignificant association of p53 expression with survival. A recent meta-analysis has demonstrated a significant effect of p53 expression on overall survival in oral cancer [13].…”

Section: Discussionsupporting

confidence: 82%

Prognostic significance of p16, p53, Bcl-2, and Bax in oral and oropharyngeal squamous cell carcinoma

2014

View full text Add to dashboard Cite

Background:The proteins p16, p53, Bcl-2, and Bax are important cell cycle and apoptotic regulators involved in carcinogenesis and found to have prognostic significance in various cancers. However, the data for squamous cell carcinoma of oral cavity (OSCC) and of oropharynx (OPSCC) are conflicting. Objective: We sought to determine if expression of p16, p53, Bcl-2, and Bax expression are associated with 5-year overall survival (OS) of patients with OSCC and OPSCC. Methods: One-hundred thirty-seven cases of OSCC and 140 cases of OPSCC diagnosed from January 2002 to December 2004 at Songklanagrind Hospital, Songkhla, Thailand, were analyzed using a Cox proportional hazards model for 5-year OS in relation to immunohistochemical detection of Bcl-2, Bax, p53, and p16 proteins. Results: The frequencies of p16, p53, Bcl-2, and Bax expression in OSCC were 13%, 45%, 4%, and 66%, and in OPSCC were 18%, 53%, 22%, and 75%, respectively. In univariate analysis, clinical variables including T stage, N stage and treatment were significantly associated with survival. In multivariate Cox regression, Bax overexpression was significantly associated with poor survival both in OSCC (HR 1.77, 95% CI 1.04-3.01) and in OPSCC (HR 2.21, 95% CI 1.00-4.85). We found no significant association of p16, Bcl-2, and p53 expression with survival. Conclusion:The expression pattern of p16, p53, Bcl-2, and Bax are similar in OSCC and OPSCC. Only Bax expression has prognostic significance for both tumor sites.

show abstract

Section: Discussionsupporting

confidence: 82%

Prognostic significance of p16, p53, Bcl-2, and Bax in oral and oropharyngeal squamous cell carcinoma

2014

View full text Add to dashboard Cite

show abstract

“…3 In HNSCC, several studies have reported that overexpression of p53 correlates with clinicopathologic characteristics of the tumor, such as lymph node metastases, and disease survival. 4 However, a number of other studies failed to demonstrate a correlation between p53 expression and these clinicopathologic variables. 3,5 The degree of heterogeneity in HNSCC in terms of the population of patients, disease site, stage, treatment, and supportive care limits the suitability of HNSCC for analysis.…”

mentioning

confidence: 98%

P53 expression in squamous cell carcinomas of the supraglottic larynx and its lymph node metastases

Cabanillas

Rodrigo

Astudillo

et al. 2007

Cancer

View full text Add to dashboard Cite

BACKGROUND.Although p53 overexpression is frequent in head and neck squamous cell carcinomas (HNSCCs), controversy remains regarding the prognostic significance of that overexpression. The objective of this study was to investigate the expression pattern and prognostic significance of p53 expression in HNSCC of the same location, treated in the same way, and with long‐term follow‐up.METHODS.P53 expression was determined by immunohistochemistry in paraffin‐embedded tissue specimens from 107 consecutive patients (107 primary squamous cell carcinomas of the supraglottic larynx and 46 matched lymph node metastases). All patients underwent surgical resection and bilateral neck dissection.RESULTS.A strong correlation was observed between p53 expression in the primary tumor and in the matched lymph node metastases (P = .0001). P53 overexpression in the lymph nodes was an independent predictor of regional recurrence (P = .027). Likewise, expression of p53 in the lymph nodes correlated significantly with disease‐specific survival (P = .018). Five years after treatment, 70% of patients with p53‐negative, metastatic lymph nodes remained alive, whereas only 30% of patients with p53‐positive lymph nodes remained alive. In multivariate analysis, lymph node status and p53 expression in the lymph nodes remained associated with survival.CONCLUSIONS.The current data suggested that, although p53 overexpression is common in supraglottic carcinomas, its expression in the primary tumor is of limited clinical significance. However, the results supported the role of p53 in the lymph node metastases as an independent predictor of regional failure and a poor prognosis in patients with HNSCC. A prospective trial is indicated to validate these findings. Cancer 2007. © 2007 American Cancer Society.

show abstract

“…Local recurrence was defined as a recurrence in the original tumour bed (Chao et al, 2012). The overall survival time was defined as the interval between the dates of the beginning of the treatment (surgery) and the death or the last information for censored observations (Waitzberg et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

“…The p53 is one the most frequently studied molecular markers in HNSCC (Van Houten et al, 2002;Waitzberg et al, 2004;Poeta et al, 2007;Jalali et al, 2011). It is the p53 that plays a significant role in pathways that are responsible for maintaining cellular integrity (Bradford et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…This finding indicate some limitations of histological diagnosis and the potential for molecular markers to guide clinicians in the management of HNSCC (Nathan et al, 2000). It has been highlighted that the overexpression of p53 is often associated with clinicopathological findings of the tumour, lymph node metastases, and survival of HNSCC patients (Waitzberg et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An Australian Retrospective Study to Evaluate the Prognostic Role of p53 and eIF4E Cancer Markers in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC): Study Protocol

Singh¹,

Jayaraj²,

Baxi³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Complete surgical resection of the primary tumour is a crucial predictive step for head and neck squamous cell carcinoma (HNSCC), because incomplete resection may lead to increase in the recurrence rate. Molecular cancer markers have been investigated as potential predictors of prognosis marker, to identify patients who are at high risk of local recurrence. This retrospective study aimed to determine the prognostic correlation between p53 and eIF4E expression and clinical characteristics, recurrence and overall survival. 1-74 months). The Kaplan-Meier method was used to generate recurrence and survival curves. This is a first retrospective study of Northern Territory patients, including Indigenous and non-Indigenous Australians. Molecular study of surgical margins could help to identify patients with and without clear margins after surgery and help in choice of the most appropriate adjuvant treatment for HNSCC patients.

show abstract

Clinical significance of c-myc and p53 expression in head and neck squamous cell carcinomas

Cited by 30 publications

References 27 publications

Prognostic significance of p16, p53, Bcl-2, and Bax in oral and oropharyngeal squamous cell carcinoma

Prognostic significance of p16, p53, Bcl-2, and Bax in oral and oropharyngeal squamous cell carcinoma

P53 expression in squamous cell carcinomas of the supraglottic larynx and its lymph node metastases

An Australian Retrospective Study to Evaluate the Prognostic Role of p53 and eIF4E Cancer Markers in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC): Study Protocol

Contact Info

Product

Resources

About