Clinical significance of cefazolin inoculum effect in serious MSSA infections: a systematic review
Calvin Ka-Fung Lo,
Ashwin Sritharan,
Jiesi Zhang
et al.
Abstract:Background
The cefazolin inoculum effect (CzIE) is a phenomenon whereby some MSSA isolates demonstrate resistance to cefazolin when a high bacterial inoculum is used for susceptibility testing. The clinical significance of this phenotypic phenomenon remains unclear. We conducted a systematic review to answer the following question: In patients with serious MSSA infection treated with cefazolin, does infection due to CzIE-positive MSSA isolates result in worse clinical outcomes than infection … Show more
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