Clinical significance of changes in the expression level of markers of surrogate breast cancer subtypes in recurrent  and metastatic foci (literature review)

Круминь, Ю. С.; Хайленко, В. А.; Козлов, Н. А.; Черемис, Г. Ю.; Петровский, А. В.; Хайленко, Д. В.; Артамонова, Е. В.; Коваленко, Е. И.

doi:10.17650/1994-4098-2020-16-3-41-45

Opuholi ženskoj reproduktivnoj sistemy

2021

DOI: 10.17650/1994-4098-2020-16-3-41-45

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Clinical significance of changes in the expression level of markers of surrogate breast cancer subtypes in recurrent and metastatic foci (literature review)

Ю. С. Круминь

В. А. Хайленко

Н. А. Козлов

et al.

Abstract: The article analyzes data from the world literature for the period from 2005 to 2020 on the relationship between the variability of immunohistochemical expression of estrogen and progesterone receptors, HER2/neu protein and the index of proliferative activity in invasive breast cancer with the course of the disease and the response to medication.

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2023

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Paget’s disease of the breast: a contemporary perspective

Yemelyanova,

Zikiryakhodzhaev,

Volchenko

et al. 2023

Issled. prakt. med. (Print)

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The treatment strategy for Paget’s breast cancer (PBC), as for other morphological forms, is determined by the spread of the invasive tumor process, as well as the absence or presence of adverse factors. Significant prognostic factors, e.g. the invasive component of Paget’s cancer, the involvement status of regional lymph nodes, morphological criteria, the grade of malignancy, overexpression of epidermal growth factor Her2/neu, the presence of BRCA 1/2 and CHEK2 gene mutations, as well as age, affect the prognosis of Paget’s disease. According to various sources, PBC in 90–98 % is combined with invasive or non‑invasive breast cancer. For the most part, the lesion is multifocal. There’s high expectation for PBC to form tumor node. A palpable tumor node in the mammary gland is detected in half of the patients. PBC has certain features and specificity in relation to treatment methods. The method of radical surgical treatment of patients is primarily based on performing oncoplastic resections. Sufficient breast volume is a significant criterion for the possibility of performing an organ‑ preserving operation. The organ‑ preserving treatment is oncologically safe in case of PBC. The removal of the nipple‑ areolar complex is mandatory in case of PBC. It is possible to improve survival statistics by analyzing the biological characteristics of the tumor and developing a more accurate approach to the treatment of patients in this category. Determining clear indications for organ‑p reserving operations is the main opportunity to improve the quality of life of patients and their further rehabilitation.

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Paget’s disease of the breast: a contemporary perspective

Yemelyanova,

Zikiryakhodzhaev,

Volchenko

et al. 2023

Issled. prakt. med. (Print)

View full text Add to dashboard Cite

show abstract

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Clinical significance of changes in the expression level of markers of surrogate breast cancer subtypes in recurrent and metastatic foci (literature review)

Cited by 1 publication

References 31 publications

Paget’s disease of the breast: a contemporary perspective

Paget’s disease of the breast: a contemporary perspective

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