Clinical significance of contrast-enhanced ultrasound in chronic kidney disease: a pilot study

Jeong, Seokmin; Park, Sung Bin; Kim, Suhyun; Hwang, Jin Ho; Shin, Jungho

doi:10.1007/s40477-019-00409-x

Cited by 17 publications

(17 citation statements)

References 31 publications

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“…The CKD group was diagnosed based on the histological or nephrological findings and was classified based on the GFR category [ 2 ]. Included CKD patients were stratified into three groups: group I, eGFR ≥ 60 ml/min/1.73 m 2 (GFR category I and II); group II, 30 ml/min/1.73 m 2 ≤ eGFR < 60 ml/min/1.73 m 2 (GFR category III); and group III, eGFR < 30 ml/min/1.73 m 2 (GFR category IV and V) [ 21 ]. The inclusion criterion for the normal control group was an eGFR > 90 ml/min/1.73 m 2 .…”

Section: Methodsmentioning

confidence: 99%

“…US examination was performed in a more accessible kidney with a larger size and thicker cortex to reduce the investigation time [ 21 ]. SonoVue ® (Bracco, Milano, Italy) was used as a US contrast agent.…”

Section: Methodsmentioning

confidence: 99%

“…Not only static images but also dynamic cine images were recorded for retrospective analysis. Satisfactory uptake usually lasted for 2 min in the kidneys [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

“…CEUS can improve the imaging of RBF and lesional vascularity in real-time with exquisite temporal and spatial resolution [ 7 - 16 ]. Although CEUS can easily demonstrate the severity of renal cortical microvascular perfusion deficits [ 4 , 14 - 21 ], there have been only a few studies to evaluate CKD using CEUS [ 17 , 18 , 21 ]. In our previous pilot study [ 21 ], we found no significant differences between the perfusion parameters among three groups of patients with CKD.…”

Section: Introductionmentioning

confidence: 99%

“…Although CEUS can easily demonstrate the severity of renal cortical microvascular perfusion deficits [ 4 , 14 - 21 ], there have been only a few studies to evaluate CKD using CEUS [ 17 , 18 , 21 ]. In our previous pilot study [ 21 ], we found no significant differences between the perfusion parameters among three groups of patients with CKD. We also found no correlation between the perfusion parameters and the estimated GFR (eGFR).…”

Section: Introductionmentioning

confidence: 99%

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Usefulness of Contrast-enhanced Ultrasound in the Evaluation of Chronic Kidney Disease

Han

Park

2021

CMIR

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Background: Contrast-enhanced ultrasound (CEUS) can provide more improved images of renal blood flow and much more information of both macro- and microcirculation of the kidney as comparing to Doppler US. Objective: To investigate the usefulness of CEUS by analyzing differences in perfusion-related parameters among the three chronic kidney disease (CKD) subgroups and the control group. Methods: Thirty-eight patients with CKD and 21 controls who were age matched (20−49 years) and included. Included CKD patients were stratified into three groups according to their eGFR: group I, eGFR ≥ 60 ml/min/1.73 m2 (GFR category I and II); group II, 30 ml/min/1.73 m2 ≤ eGFR < 60 ml/min/1.73 m2 (GFR category III); and group III, eGFR < 30 ml/min/1.73 m2 (GFR category IV and V). Comparisons with the controls (eGFR > 90 ml/min/1.73 m2 ) were performed. Real-time and dynamic renal cortex imaging was performed using CEUS. Time-intensity curves and several bolus model quantitative perfusion parameters were created using the VueBox® quantification software. We compared the parameters among the CKD subgroups and between the CKD and control groups. Results: Eight patients were included in group I, 12 patients in group II, and 18 patients in group III. Significant differences were noted in the wash-in and wash-out rates between the CKD and control groups (p = 0.027 and p = 0.018, respectively), but not between those of the CKD subgroups. There were no significant differences of other perfusion parameters among the CKD subgroups and between the CKD and control groups. Conclusion: A few perfusion related CEUS parameters (WiR and WoR) can be used as markers of renal microvascular perfusion relating renal function. CEUS can effectively and quantitatively exhibit the renal microvascular perfusion in patients with CKD as well as normal control participants.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Not only static images but also dynamic cine images were recorded for retrospective analysis. Satisfactory uptake usually lasted for 2 min in the kidneys [ 21 ].…”

Section: Methodsmentioning

confidence: 99%