Clinical Significance of Coronary Artery Disease Genetic Markers: Reality or Far Future?

Шестерня, П. А.; Шульман, В. А.; Никулина, С. Ю.; Сергеева, Анна; Демкина, А. И.; Максимов, В. Н.; Воевода, М. И.

doi:10.15829/1560-4071-2014-10-7-12

Ross. kardiol. ž.

2015

DOI: 10.15829/1560-4071-2014-10-7-12

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Clinical Significance of Coronary Artery Disease Genetic Markers: Reality or Far Future?

П. А. Шестерня¹,

В. А. Шульман²,

С. Ю. Никулина³

et al.

Abstract: Цель. Оценить возможность клинического применения данных генотипирова-ния локуса 9р21.3 у больных ИМ. Материал и методы. В исследование включено 500 больных ИМ в возра-сте ≤65 лет [Ме 54,0; Q 25 48,0; Q 75 59,0], в т. ч. 411 (82,2%) мужчин и 89 (17,8%) женщин, и данные 31 аутопсии -24 мужчин и 7 женщин в возра-сте ≤65 лет (57,87±5,92 лет) с верифицированным ИМ, как причиной смерти. Группа контроля состояла из 423 (79,1%) CLINICAL SIGNIFICANCE OF CORONARY ARTERY DISEASE GENETIC MARKERS: REALITY OR FAR F… Show more

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Genetics of healthy aging and longevity

Pavlova,

Erina,

Rotar

et al. 2024

Arter. gipertenz.

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With the increase in life expectancy, there is an increase in the number of elderly people among the population, therefore, an important task for Russian health care is to ensure healthy aging. An examination of a group of centenarians can help in studying the factors and causes that contribute to a long life without development or with the later development of age-associated diseases. In many ways, the long life expectancy and better health of such people are genetically determined. At the same time, longevity, as a complex sign, is influenced by many genetic polymorphisms, often with a small individual effect. Identification of hereditary determinants and their effects on the mechanisms of aging is necessary to identify the foundations of healthy longevity and to find protector mechanisms and targets by which it is possible to prevent the occurrence or slow the progression of age-related diseases.The pathology of the cardiovascular system is the most significant of the diseases associated with aging, since it is the leading cause of mortality according to world statistics. Thus, cardiovascular aging is an important factor in determining a person’s life expectancy.This article examines the methodological aspects of studies involving centenarians, and also provides an overview of genes that affect both life expectancy and longevity, as well as the development and course of cardiovascular diseases.

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Genetics of healthy aging and longevity

Pavlova,

Erina,

Rotar

et al. 2024

Arter. gipertenz.

View full text Add to dashboard Cite

show abstract

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Clinical Significance of Coronary Artery Disease Genetic Markers: Reality or Far Future?

Cited by 1 publication

References 17 publications

Genetics of healthy aging and longevity

Genetics of healthy aging and longevity

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