1994
DOI: 10.1249/00005768-199410000-00013
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Clinical significance of coronary vascular adaptations to exercise training

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Cited by 20 publications
(19 citation statements)
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“…In addition, we report that enhanced bradykininmediated relaxation of collateral-dependent arterioles involves increased expression of ecNOS mRNA. Importantly, these findings provide insight into potential mechanisms underlying improved blood flow/ischemia of collateralized myocardium after exercise training in experimental animals, 2,3,6 as well as the well-documented beneficial effects of exercise training in human patients with coronary artery disease. 19 -21 …”
Section: Discussionmentioning
confidence: 85%
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“…In addition, we report that enhanced bradykininmediated relaxation of collateral-dependent arterioles involves increased expression of ecNOS mRNA. Importantly, these findings provide insight into potential mechanisms underlying improved blood flow/ischemia of collateralized myocardium after exercise training in experimental animals, 2,3,6 as well as the well-documented beneficial effects of exercise training in human patients with coronary artery disease. 19 -21 …”
Section: Discussionmentioning
confidence: 85%
“…[1][2][3][4][5] Myocardial ischemia and inotropic dysfunction may occur, however, during periods of increased cardiac workload because of inadequate perfusion of the collateraldependent myocardial region. [1][2][3]6 Importantly, Roth et al 2 demonstrated that the perfusion deficit and contractile dysfunction of collateral-dependent myocardium was improved by chronic (16-week) exercise training in pigs. Increased collateral development has been proposed to underlie training-induced improved perfusion of the diseased heart 2,3,6 ; however, synergistic effects of chronic exercise on improved microvascular vasomotor function of collateral-dependent vasculature may also be involved.…”
mentioning
confidence: 99%
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“…Collateral development at 8 weeks in this model provides adequate blood flow in resting myocardium 20,21 but insufficient flow during physiological stress. 3,20,21 Possibly, at 7 to 9 weeks, collateral development may be more limited than at 22 weeks, inadequately perfusing "resting" myocardium and potentially causing variable ischemic episodes stimulating enhanced VEGF-induced responses under sedentary conditions. 26…”
Section: Vasodilation To Vegf 165mentioning
confidence: 99%
“…[1][2][3][4] CCO creates a proangiogenic environment that is dependent on the presence of growth factors and appropriate receptors. 1,5 Indeed, increased myocardial release of vascular endothelial growth factor (VEGF) has been demonstrated after coronary artery occlusion.…”
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confidence: 99%