Clinical significance of corpus callosum atrophy in a mixed elderly population

Ryberg, Charlotte; Rostrup, Egill; Stegmann, Mikkel Bille; Barkhof, Frederik; Scheltens, Philip; Straaten, E.C.W. van; Fazekas, Franz; Schmidt, Reinhold; Ferro, José M.; Baezner, Hansjoerg; Erkinjuntti, Timo; Jokinen, Hanna; Wahlund, Lars‐Olof; O’Brien, John; Basile, Anna; Pantoni, Leonardo; Inzitari, Domenico; Waldemar, Gunhild

doi:10.1016/j.neurobiolaging.2006.04.008

Cited by 67 publications

(68 citation statements)

References 55 publications

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“…On the other hand, two diffusion tensor imaging studies have not found evidence of callosal abnormalities (Bae et al, 2006;Nobuhara et al, 2006) in depressed elders. In addition, one report employing Witelson's segmentation criteria of corpus callosum areas obtained from midsagittal MRI section in a mixed elderly population did not detect an association between callosal atrophy and mood disturbances (Ryberg et al, 2007). The lack of consistency in findings may reflect methodologic differences in imaging and sample characteristics, or effects may be relatively subtle and difficult to detect in small samples.…”

Section: Discussionmentioning

confidence: 95%

Mapping Callosal Morphology in Early- and Late-Onset Elderly Depression: An Index of Distinct Changes in Cortical Connectivity

Ballmaier

Kumar

Elderkin‐Thompson

et al. 2007

Neuropsychopharmacol

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There is some evidence of corpus callosum abnormalities in elderly depression, but it is not known whether these deficits are regionspecific or differ based on age at onset of depression. Twenty-four patients with early-onset depression (mean age ¼ 68.00, SD75.83), 22 patients with late-onset depression (mean age ¼ 74.50, SD78.09) and 34 elderly control subjects (mean age ¼ 72.38; SD76.93) were studied. Using 3D MRI data, novel mesh-based geometrical modeling methods were applied to compare the midsagittal thickness of the corpus callosum at high spatial resolution between groups. Neuropsychological correlates of midsagittal callosal area differences were additionally investigated in a subsample of subjects. Depressed patients exhibited significant callosal thinning in the genu and splenium compared to controls. Significant callosal thinning was restricted to the genu in early-onset patients, but patients with late-onset depression exhibited significant callosal thinning in both the genu and splenium relative to controls. The splenium of the corpus callosum was also significantly thinner in subjects with late-vs early-onset depression. Genu and splenium midsagittal areas significantly correlated with memory and attention functioning among late-onset depressed patients, but not early-onset depressed patients or controls. Circumscribed structural alterations in callosal morphology may distinguish late-from early-onset depression in the elderly. These findings suggest distinct abnormalities of cortical connectivity in late-and early-onset elderly depression with possible influence on the course of illness. Patients with a late onset of depression may be at higher risk of illness progression and eventually dementia conversion than earlyonset depression, with potentially important implications for research and therapy.

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Section: Discussionmentioning

confidence: 95%

Mapping Callosal Morphology in Early- and Late-Onset Elderly Depression: An Index of Distinct Changes in Cortical Connectivity

Ballmaier

Kumar

Elderkin‐Thompson

et al. 2007

Neuropsychopharmacol

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“…Statistical significance was set at P Ͻ .05 corrected for multiple comparison using the false discovery rate method. 35 Because previous studies reported a correlation between atrophy of the corpus callosum and gait disorder and cognitive deficits in patients with LA, [36][37][38] we also performed a correlation between FA maps and motor scores and between MD and FA maps and cognitive scores using a small volume correction. This was accomplished by selecting the voxels of interest corresponding with the Talairachbased mask of the corpus callosum provided by the Wake Forest University PickAtlas (Winston Salem, NC).…”

Section: Methodsmentioning

confidence: 99%

Whole-Brain Histogram and Voxel-Based Analyses of Diffusion Tensor Imaging in Patients with Leukoaraiosis: Correlation with Motor and Cognitive Impairment

Nave¹,

Foresti²,

Pratesi³

et al. 2007

American Journal of Neuroradiology

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BACKGROUND AND PURPOSE:Cerebral white matter changes, termed leukoaraiosis (LA), appearing as areas of increased signal intensity in T2-weighted MR images, are common in elderly subjects, but the possible correlation of LA with cognitive or motor deficit has not been established. We hypothesized that histogram and voxel-based analyses of whole-brain mean diffusivity (MD) and fractional anisotropy (FA) maps calculated from diffusion tensor imaging (DTI) could be more sensitive tools than visual scales to investigate the clinical correlates of LA.

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“…The corpus callosum is a dense bundle of neural fibres that connects the two cerebral hemispheres of the brain. Previous studies have reported a critical link between white matter integrity in the corpus callosum and both cognitive and mobility measures (e.g., Bhadelia et al, 2009;Frederiksen et al, 2011;Moscufo et al, 2011;Moscufo et al, 2012;Ryberg et al, 2011;Ryberg et al, 2007). Of particular relevance, atrophy in the splenium -a posterior region of the corpus callosum -appears to be most associated with reduced general mobility (e.g., Frederiksen et al, 2011;Moscufo et al, 2011;Moscufo et al, 2012) as measured by the Short Physical Performance Battery (SPPB) (Guralnik, Ferrucci, Simonsick, Salive, & Wallace, 1995).…”

Section: Primary Findingmentioning

confidence: 99%

Altered visual–spatial attention to task-irrelevant information is associated with falls risk in older adults

et al. 2013

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Executive cognitive functions play a critical role in falls risk -a pressing health care issue in seniors. In particular, intact attentional processing is integral for safe mobility and navigation. However, the specific contribution of impaired visual-spatial attention in falls remains unclear. In this study, we examined the association between visual-spatial attention to task-irrelevant stimuli and falls risk in community-dwelling older adults. Participants completed a visual target discrimination task at fixation while task-irrelevant probes were presented in both visual fields. We assessed attention to left and right peripheral probes using event-related potentials (ERPs). Falls risk was determined using the valid and reliable Physiological Profile Assessment (PPA). We found a significantly positive association between reduced attentional facilitation, as measured by the N1 ERP component, and falls risk. This relationship was specific to probes presented in the left visual field and measured at ipsilateral electrode sites. Our results suggest that fallers exhibit reduced attention to the left side of visual space and provide evidence that impaired right hemispheric function and/or structure may contribute to falls.

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Clinical significance of corpus callosum atrophy in a mixed elderly population

Cited by 67 publications

References 55 publications

Mapping Callosal Morphology in Early- and Late-Onset Elderly Depression: An Index of Distinct Changes in Cortical Connectivity

Mapping Callosal Morphology in Early- and Late-Onset Elderly Depression: An Index of Distinct Changes in Cortical Connectivity

Whole-Brain Histogram and Voxel-Based Analyses of Diffusion Tensor Imaging in Patients with Leukoaraiosis: Correlation with Motor and Cognitive Impairment

Altered visual–spatial attention to task-irrelevant information is associated with falls risk in older adults

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