Clinical Significance of Cystatin C-Based Estimates of Renal Function in Type 2 Diabetic Patients: Review

Fiseha, Temesgen

doi:10.21767/2386-5180.100011

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…These equations were useful for early detection of renal dysfunction and is a better risk predictor amongst patients with diabetic mellitus when compared to the creatinine-based eGFR equations. 20 Rapid detection of reduced renal function will allow earlier intervention and hence, prevent further deterioration of kidney problem. Cystatin C-based eGFR showed a better accuracy in predicting prognosis when compared to creatinine-based eGFR, thus utilisation of cystatin C was suggested.…”

Section: Introductionmentioning

confidence: 99%

Agreement between Creatinine and Cystatin C-Based Equations in the Estimation of Glomerular Filtration Rate among Malaysian Patients with Renal Impairment

Tahir¹,

Gafor²,

Islahudin³

et al. 2018

IJPER

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Background: Cystatin C-based equations have been proposed as an alternative for creatinine-based equations in the estimation of Glomerular Filtration Rate (eGFR). Limited studies were available with regards to the Asian population to evaluate the agreement of eGFR measured based on both biomarkers. This study aimed to evaluate the agreement between various cystatin C-and creatinine-based eGFR equations. Methods: Patients were recruited from the Nephrology Clinic Universiti Kebangsaan Malaysia Medical Centre. Serum cystatin C and creatinine levels were analysed by particle-enhanced immunoturbidimetry assay and kinetic alkaline picrate method, respectively. Various cystatin C-based (Hoek, Larsson, Grubb, Flodin, cystatin C-based Chronic Kidney Disease Epidemiology (CKD-EPI)) and creatinine-based eGFR equations (Cockcroft-Gault, Modification of Diet in Renal Disease, creatinine-based CKD-EPI) were compared by using the Pearson's correlation and Bland-Altman plot. Results: A total of 118 patients included in this study have a mean age of 61±15 years and 57.6% were female. The mean serum cystatin C and creatinine levels were 2.00±1.06 mg/L and 2.21±1.63 mg/dL, respectively. The correlation between serum cystatin C and creatinine level was significant (r=0.78, P<0.01). All cystatin C-based eGFR correlated significantly with the creatinine-based eGFR equations. The strongest correlation was between creatininebased and cystatin C-based CKD-EPI equation (r=0.93, P<0.01). The Bland-Altman plot shows that cystatin C-based CKD-EPI equation had the least mean difference when compared with creatinine-based CKD-EPI equation. Conclusion: Significant correlation and good agreement were demonstrated between various cystatin C-based and creatininebased eGFR equations. The cystatin C-based equations are appropriate alternative for GFR measurement among Malaysian patients with renal impairment.

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Section: Introductionmentioning

confidence: 99%

Agreement between Creatinine and Cystatin C-Based Equations in the Estimation of Glomerular Filtration Rate among Malaysian Patients with Renal Impairment

Tahir¹,

Gafor²,

Islahudin³

et al. 2018

IJPER

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“…Cystatin‐C is not routinely found in urine in significant quantities . Raised urinary altitudes of cystatin‐C may reveal tubular dysfunction independent of GFR . Acute cystatin‐C fluctuations may consequently afford more truthful AKI diagnosis; this would upsurge authority of novel biomarker and of AKI‐outcome studies .…”

Section: Introductionmentioning

confidence: 99%

“…[6] Raised urinary altitudes of cystatin-C may reveal tubular dysfunction independent of GFR. [7] Acute cystatin-C fluctuations may consequently afford more truthful AKI diagnosis; this would upsurge authority of novel biomarker and of AKI-outcome studies. [8] Some studies have proposed that serum cystatin-C upswing with AKI befalls before rise in SCr, leading to assessment of cystatin-C as an early AKI biomarker.…”

Section: Introductionmentioning

confidence: 99%

Relevance of cystatin‐C, N‐acetylglucosaminidase, and Interleukin‐18 with the diagnosis of acute kidney injury induced by cadmium in rats

Ali

Elshaer

Anwar

et al. 2017

J Biochem & Molecular Tox

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The diagnosis of acute kidney injury (AKI) is frequently established on modifications in serum creatinine (SCr). The discriminative and prognostic aptitudes of serum cystatin-C as well as N-acetylglucosaminidase (NAG) and Interleukin-18 (IL-18) were inspected for the estimation of AKI. In this study twelve rats were alienated into two groups: control group received saline, second group received cadmium chloride at a dose (2.4 mg Cd/kg/day, i.p) for 30 days. Blood urea nitrogen (BUN), SCr, and IL-18 serum level were measured in addition to serum and tissue content of cystatin-C and NAG. AKI model showed significant increase in BUN, creatinine, and IL-18. RT-PCR showed upregulation of cystatin-C gene besides significant increase of its level in serum. Additionally, tissue content of NAG was significantly increased. Our findings may provide that grouping of several biomarkers for diagnosis of AKI is a more valuable diagnostic tool than single-marker measurement.

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Association between cystatin C and major adverse cardiac events in patients with ischemic heart disease and type 2 diabetes mellitus after acute coronary syndrome

Serik

Ovrakh

2019

ZMJ

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Clinical Significance of Cystatin C-Based Estimates of Renal Function in Type 2 Diabetic Patients: Review

Cited by 4 publications

References 38 publications

Agreement between Creatinine and Cystatin C-Based Equations in the Estimation of Glomerular Filtration Rate among Malaysian Patients with Renal Impairment

Agreement between Creatinine and Cystatin C-Based Equations in the Estimation of Glomerular Filtration Rate among Malaysian Patients with Renal Impairment

Relevance of cystatin‐C, N‐acetylglucosaminidase, and Interleukin‐18 with the diagnosis of acute kidney injury induced by cadmium in rats

Association between cystatin C and major adverse cardiac events in patients with ischemic heart disease and type 2 diabetes mellitus after acute coronary syndrome

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