2003
DOI: 10.1038/sj.bmt.1704369
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Clinical significance of cytomegalovirus (CMV) antigenemia in the prediction and diagnosis of CMV gastrointestinal disease after allogeneic hematopoietic stem cell transplantation

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Cited by 103 publications
(65 citation statements)
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“…A higher rate of negative pp65Ag screening tests compared with quantPCR have been reported in cases of CMV colitis, retinitis or other localised non-pulmonary sites of CMV-D. 13,14,33,34 In fact, an advantage in preventing GI CMV-D has been reported with PCR screening techniques in comparison to antigenemia testing. 35 However, as most cases of CMV pneumonia with prior negative screening tests occurred during the pp65Ag screening period in this study, molecular screening methods could offer higher sensitivity over pp65Ag in detecting CMV replication before the occurrence of CMV pneumonia. Nonetheless, this study has important methodological limitations, which are mainly a consequence of its retrospective design.…”
Section: Discussionmentioning
confidence: 99%
“…A higher rate of negative pp65Ag screening tests compared with quantPCR have been reported in cases of CMV colitis, retinitis or other localised non-pulmonary sites of CMV-D. 13,14,33,34 In fact, an advantage in preventing GI CMV-D has been reported with PCR screening techniques in comparison to antigenemia testing. 35 However, as most cases of CMV pneumonia with prior negative screening tests occurred during the pp65Ag screening period in this study, molecular screening methods could offer higher sensitivity over pp65Ag in detecting CMV replication before the occurrence of CMV pneumonia. Nonetheless, this study has important methodological limitations, which are mainly a consequence of its retrospective design.…”
Section: Discussionmentioning
confidence: 99%
“…However the role of these tests in detecting CMV infection before the onset of CMV gastro-intestinal disease is not conclusive. [12] Furthermore, as in our case, some cases of compartmentalized or localized CMV diseases have very low or transient periods of viremia. [13,14] On the other hand, follow-up viral load testing is useful when the decision is made to initiate treatment, testing of the viral load should be performed the day the therapy starts, followed by viral load testing with 5-to 7-day intervals, because the half-life of CMV DNA in the plasma ranges from 3 to 8 days.…”
Section: Discussionmentioning
confidence: 99%
“…The antigenemia assay is one of the most widely used methods for detecting reactivation of CMV infection, but only a few studies have examined its diagnostic value for CMV-GID, [18][19][20][21] and all were retrospective in design. Jang et al 20 recently reported that the sensitivity and specificity of the CMV antigenemia assay for the diagnosis of CMV-GID were 54% and 88%, respectively, in patients with secondary immunodeficiency disease.…”
Section: Discussionmentioning
confidence: 99%