Clinical significance of endoscopic findings in the upper gastrointestinal tract in Crohn’s disease

Dąbkowski, Krzysztof; Graca-Pakulska, Katarzyna; Zawada, Iwona; Ostrowski, Jerzy; Starzyńska, Teresa

doi:10.1080/00365521.2019.1656776

Cited by 5 publications

(6 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most common cause of gastritis is HP infection; HP-negative gastritis is relatively infrequent, representing only 1.5–21% of all cases 31 , 32 . By contrast, 70% of CD patients show evidence of microscopic inflammation, presenting as HP-negative gastritis in 10–60% of patients 3 , 33 . According to the Kyoto global consensus, HP-negative gastritis may be caused by other bacteria, including H. heilmannii , Enterococcus , Mycobacteria , and Syphilis 34 .…”

Section: Discussionmentioning

confidence: 97%

“…Depending on the population, 5–70% of all IBD cases demonstrate non-specific involvement of the stomach (this is particularly true for CD); in addition, 30–80% of CD patients show either endoscopic or histologic changes 3 .…”

Section: Discussionmentioning

confidence: 99%

“…Prospective endoscopic testing of 1015 adult CD patients identified macroscopic and microscopic findings within the upper GIT of 11.7% of patients; mostly, these findings were unspecific and of uncertain clinical relevance, with concomitant involvement of the ileocolonic region in 60% of cases 2 . However, as reviewed recently 3 , macroscopic changes in the upper GIT are found in 50-70% of patients with CD.…”

mentioning

confidence: 99%

See 2 more Smart Citations

The gastric microbiota in patients with Crohn’s disease; a preliminary study

Ostrowski

Kulecka

Zawada

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

The gastric microbiota in Crohn’s disease (CD) has not been studied. The purpose of the study was to evaluate differences of stomach microbiota between CD patients and controls. DNA was extracted from gastric mucosal and fluid samples, from 24 CD patients and 19 controls. 16S rRNA gene sequencing identified 1511 operational taxonomic units (OTUs), of which 239 passed the low abundance and low variance filters. All but one CD patients were HP negative. Fifteen bacterial phyla were identified in at least one mucosal or fluid site. Of these, Bacteroidota and Firmicutes accounted for 70% of all phyla. Proteobacteria, Actinobacteriota, and Fusobacteriota combined accounted for 27%. There was significant difference in the relative abundance of Bacteroidota, Proteobacteria, Fusobacteriota, and Campilobacterota between CD patients and controls only in gastric corpus samples. In gastric liquid, there was a significant difference only in Actinobacteriota. Pairwise comparison identified 67 differentially abundant OTUs in at least one site. Of these, 13 were present in more than one comparison, and four differentiating OTUs (Neisseriaceae, Neisseria, Absconditabacteriales, and Microbacteriaceae) were identified at all tested sites. The results reveal significant changes in gastric microbial profiles (beta diversity, phylum, and individual taxa levels) between H. pylori-negative CD patients and controls.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

The gastric microbiota in patients with Crohn’s disease; a preliminary study

Ostrowski

Kulecka

Zawada

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Conventionally, this disease is known to cause inflammation of the terminal ileum and/or colon. However, studies performed over the last two decades have reported macroscopic abnormalities that tend to commonly affect the more proximal segments of the GI tract, including upper gastrointestinal tract 8 . The exact pathogenesis of such abnormalities remains unknown, and the prevalence of involvement of the upper gastrointestinal tract among patients with Crohn’s disease is also controversial.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic findings in the upper gastrointestinal tract in patients with Crohn’s disease are common, highly specific, and associated with chronic gastritis

Graca-Pakulska

Błogowski

Zawada

et al. 2023

Sci Rep

Self Cite

View full text Add to dashboard Cite

Crohn’s disease (CD) may affect the entire gastrointestinal tract including its upper part. However, this aspect is poorly addressed in scientific literature and considered a rare finding. Here we aimed to prospectively investigate the prevalence, characteristics and clinical significance of upper gastrointestinal tract involvement in patients with CD, with particular focus on stomach bamboo joint-like appearance (BJA), Helicobacterpylori status and presence of microscopic changes. 375 prospectively recruited patients were included. In CD patients the prevalence of gastric and duodenal, but not esophageal, mucosal lesions, such as gastric mucosal inflammation, duodenal edema, ulcerations, and duodenal bulb deformation was significantly higher (at least p < 0.01 for all). Similar results were found when only H.pylori negative individuals were analyzed. Moreover, BJA of the stomach and in case of H.pylori negative patients also duodenal bulb deformation were detected exclusively in CD patients. Presence of BJA lesion was not significantly associated with neither duration of the disease nor use/history of biologic treatment. Despite absence of H.pylori infection microscopic features of chronic gastritis were found in almost all (93.5%) patients, and in 31% of controls (p < 0.00001). Our analysis outlines that upper gastrointestinal tract involvement in CD is a very common event and frequently manifests with a highly specific BJA lesion. Furthermore, our study reveals that in almost all CD patients features of H.pylori negative gastritis are present.

show abstract

“…Traditionally, UC is considered a purely colon disease other than limited terminal ileal inflammation. In recent years, however, the prevalence at initial presentation of UC-associated esophageal disease has been 12%-50%[ 10 ], while it is as high as 70% to 90% in Crohn’s disease (CD) individuals[ 21 , 22 ]. These numbers may underestimate the prevalence of the disease due to the difficulty of precise diagnosis and the lack of standard upper endoscopy in asymptomatic individuals with UC.…”

Section: Esophageal Mucosal Lesionsmentioning

confidence: 99%

Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: A review

Sun¹,

Zhang²,

Cheng³

et al. 2021

WJG

View full text Add to dashboard Cite

Ulcerative colitis (UC) is a chronic, nonspecific, relapsing inflammatory bowel disease. The colorectum is considered the chief target organ of UC, whereas upper gastrointestinal (UGI) tract manifestations are infrequent. Recently, emerging evidence has suggested that UC presents complications in esophageal, stomachic, and duodenal mucosal injuries. However, UC-related UGI tract manifestations are varied and frequently silenced or concealed. Moreover, the endoscopic and microscopic characteristics of UGI tract complicated with UC are nonspecific. Therefore, UGI involvement may be ignored by many clinicians. In addition, no standard criteria have been established for patients with UC who should undergo fibrogastroduodenoscopy. Furthermore, specific treatment recommendations may be needed for patients with UC-associated UGI lesions. Herein, we review the esophageal, gastric, and duodenal mucosal lesions of the UC-associated UGI tract, as well as the potential pathogenesis and therapy.

show abstract

Clinical significance of endoscopic findings in the upper gastrointestinal tract in Crohn’s disease

Cited by 5 publications

References 43 publications

The gastric microbiota in patients with Crohn’s disease; a preliminary study

The gastric microbiota in patients with Crohn’s disease; a preliminary study

Endoscopic findings in the upper gastrointestinal tract in patients with Crohn’s disease are common, highly specific, and associated with chronic gastritis

Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: A review

Contact Info

Product

Resources

About