Clinical Significance of Evaluation of Serum Zinc Concentrations in C-Viral Chronic Liver Disease

Moriyama, Mitsuhiko; Matsumura, Hiroshi; Fukushima, Akiko; Ohkido, Kenji; Arakawa, Yasuo; Nirei, Kazushige; Yanagimoto, Hiroaki; Kushima, Miki; Tanaka, Naohide; Arakawa, Yasuyuki

doi:10.1007/s10620-005-9051-7

Cited by 29 publications

(26 citation statements)

References 29 publications

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“…4,[42][43][44][45] To assess this zinc relationship, one must recognize that homeostatic physiological mechanisms regulate and maintain a constant normal plasma zinc concentration, which is ~12-15 uM in humans. The plasma zinc concentration is maintained basically by the balance of dietary zinc intestinal absorption and assimilation into blood, the distribution of zinc among the tissues of the body, and the "excretion" of zinc out of the body.…”

Section: The Implication Of Zinc In the Predisposition Of Hcc Developmentioning

confidence: 99%

The status of zinc in the development of hepatocellular cancer

Costello

Franklin

2014

Cancer Biology & Therapy

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Section: The Implication Of Zinc In the Predisposition Of Hcc Developmentioning

confidence: 99%

The status of zinc in the development of hepatocellular cancer

Costello

Franklin

2014

Cancer Biology & Therapy

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“…Serum Zn levels inversely correlate with the severity of hepatic fibrosis (7). Zn depletion in patients with liver cirrhosis is closely related to the progression of hepatic encephalopathy.…”

Section: Introductionmentioning

confidence: 99%

“…Zn deficiency is also frequently observed in patients with chronic liver diseases (cld), including chronic hepatitis and liver cirrhosis (5)(6)(7)(8). Serum Zn levels inversely correlate with the severity of hepatic fibrosis (7).…”

Section: Introductionmentioning

confidence: 99%

Insulin resistance derived from zinc deficiency in non-diabetic patients with chronic hepatitis C

Himoto

Yoneyama

Deguch³

et al. 2010

Experimental and Therapeutic Medicine

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Abstract. chronic hepatitis c virus (hcV) infection frequently evokes metabolic abnormalities including insulin resistance. a decrease in serum zinc (Zn) levels is often observed in association with hepatic fibrosis. Zn also plays important roles in insulin secretion. however, little is known about the relationship between Zn deficiency and insulin resistance in patients with hcV-related chronic liver disease. the main purpose of this study was to examine the contribution of Zn deficiency to insulin resistance in patients with chronic hepatitis c (ch-c). Forty-eight non-diabetic patients with ch-c were enrolled. Serum alanine aminotransferase (alt), ferritin and Zn levels were examined in the enrolled patients with ch-c. insulin resistance was determined by the homeostasis model for assessment of insulin resistance (HOMA-IR). Zn deficiency was defined as serum Zn levels <65 µg/dl. Seven out of the 48 (15%) patients with CH-C fulfilled the criteria for Zn deficiency. Serum Zn levels were inversely correlated with serum ferritin levels (r=-0.364, p=0.0140). The values of HOMA-IR were positively linked to serum ferritin levels (r=0.299, p=0.0484). The mean value of HOMA-IR in the Zn deficiency group was significantly higher than that in the normal-range Zn group (3.76±0.66 vs. 2.08±1.35, p=0.0019). Serum ALT levels were also closely associated with serum ferritin levels (r=0.727, p<0.001). These findings were independent of HCV genotypes or loads of hcV-rna. Our data suggest that iron overload in patients with CH-C derives from Zn deficiency and thereby causes insulin resistance. IntroductionZinc (Zn) is an essential trace element that serves as the active center of approximately 300 enzymes and participates in physiological functions including immune function, neurosensory function, protein metabolism, wound healing and sexual function (1,2). Zn plays important roles as a growth co-factor, an immunomodulator and a cytoprotectant with antioxidant, antiapoptotic and anti-inflammatory effects (3,4). Therefore, Zn depletion results in numerous types of symptoms including taste disorder, hyperkeratotic skin change, wound healing disturbance and testicular dysfunction.Zn deficiency is also frequently observed in patients with chronic liver diseases (cld), including chronic hepatitis and liver cirrhosis (5-8). Serum Zn levels inversely correlate with the severity of hepatic fibrosis (7). Zn depletion in patients with liver cirrhosis is closely related to the progression of hepatic encephalopathy. Zn deficiency usually leads to a decrease in the activity of ornitine transcarbamylase, a key Zn-containing enzyme for the urea cycle. this consequently causes the accumulation of ammonia and seems to account for the pathogenesis of hepatic encephalopathy (9). Zn administration has favorable effects on the inhibition of hepatic fibrosis, activating collagenase, which belongs to a zinc-metallo-enzyme, and/or diminishing prolyl hydroxylase, which contributes to collagen synthesis (10). Zn supplementation also relieves hepatic ence...

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“…Because serum zinc concentration decreased in the advanced stage of hepatitis C, 18 the increase of zinc in O cells might be the results of homeostatic HCV suppression in infected cells, such as hepatocytes. Anyhow further study is needed to elucidate the precise relationship of zinc and HCV.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Intracellular Zinc in HCV Replicon

Yuasa¹,

Takizawa²,

Takagi³

et al. 2017

Gastro - Open J

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Aim: In patients with chronic liver injury, metabolic disturbance of zinc was frequently observed and Hepatitis C virus (HCV) replication is crucially involved with zinc metabolism. In vitro HCV replication system, HCV replicon enabled us to analyze HCV replication in vitro.Here we aimed to quantitatively analyze the zinc in a HCV-infected hepatocyte, namely HCV replicon and control. Methods: Genome-length HCV RNA-replicating cells, namely replicon cells (HCV-O cells) and control cells were treated with zinc salts and assayed their zinc content by in-air micro-PIXE analyzer. Metallothionein (MT) which is a major reserve of zinc was also analyzed by Cd-hem assay. Results: 1) Micro-PIXE analysis revealed that zinc concentration was increased more in HCV-O cells than control. Additional zinc by zinc chloride administration enhanced the peak of zinc in both control and HCV replicon cells. Furthermore, the degree of zinc increment by additional zinc is more in HCV-O cells than control. 2) Cd-hem assay also demonstrated the increase of zinc in HCV-O cells and zinc stimulation further increased the metallothionein content in HCV-O cells. Conclusion: In-air-micro-PIXE and Cd-hem assay revealed the increase of zinc and metallothionein in HCV-O. Metallothionein increased and additional zinc also increased more in HCV-O. Thus, HCV infection increased zinc at least partially through metallothionein.

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Clinical Significance of Evaluation of Serum Zinc Concentrations in C-Viral Chronic Liver Disease

Cited by 29 publications

References 29 publications

The status of zinc in the development of hepatocellular cancer

The status of zinc in the development of hepatocellular cancer

Insulin resistance derived from zinc deficiency in non-diabetic patients with chronic hepatitis C

Analysis of the Intracellular Zinc in HCV Replicon

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