Clinical significance of extra-pulmonary involvement of invasive aspergillosis: a retrospective autopsy-based study of 107 patients

Hori, Akiko; Kami, Masahiro; Kishi, Yukiko; Machida, Utako; Matsumura, Tomoko; Kashima, Takeshi

doi:10.1053/jhin.2001.1170

Cited by 81 publications

(66 citation statements)

References 26 publications

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“…A. niger, the species identifi ed in our case, was found in only 4 cases (11%). In postmortem series, less than 5% of all patients Acute lymphocytic leukemia with superimposed invasive aspergillosis and pneumopericardium successfully treated with voriconazole Carlos L. Alviar, MD, Bryan Doherty, MD, and Muthiah Vaduganathan, MD, MPH with invasive aspergillosis had evidence of pericardial infi ltration (6)(7)(8). Th is condition occurs primarily in severely immunocompromised patients and is generally a result of contiguous dissemination of Aspergillus from the lung or myocardium (9,10).…”

Section: Discussionmentioning

confidence: 99%

Acute Lymphocytic Leukemia with Superimposed Invasive Aspergillosis and Pneumopericardium Successfully Treated with Voriconazole

Alviar

Doherty

Vaduganathan

2014

Baylor University Medical Center Proceedings

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Section: Discussionmentioning

confidence: 99%

Acute Lymphocytic Leukemia with Superimposed Invasive Aspergillosis and Pneumopericardium Successfully Treated with Voriconazole

Alviar

Doherty

Vaduganathan

2014

Baylor University Medical Center Proceedings

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“…In autopsy series, 85-90% of patients with cardiac mycosis of any type also had disseminated disease [5,10]. Furthermore, a study of 107 patients with invasive aspergillosis (IA) revealed that the heart was the most common site of extra-pulmonary aspergillosis, occurring in 60% of patients with disseminated disease and in 28% of patients with IA [11].…”

Section: Aetiology and Epidemiologymentioning

confidence: 99%

“…Native valve endocarditis accounts for approximately 17% of cases or cardiac aspergillosis [11]. Native valve endocarditis typically occurs in individuals with profound immune dysfunction without previous cardiac surgery [3].…”

Section: Native Valve Endocarditismentioning

confidence: 99%

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Cardiac Aspergillosis

Lagacé-Wiens¹,

Rubinstein²

2009

Aspergillosis: From Diagnosis to Prevention

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Cardiac aspergillosis has been increasingly recognized as a complication of immunocompromise in recent times. The use of progressively more potent immunosuppressive agents and the longer survival times of transplant recipients is likely contributing to an increasing prevalence of the disease. Although still uncommon, the disease has an extremely high mortality rate and management remains difficult. Cardiac aspergillosis can present as combinations of endocarditis, myocardial invasion or pericarditis and commonly occurs in the context of disseminated aspergillosis. Myocardial involvement is most common, followed by endocarditis although the various forms frequently co-exist. Diagnosis is challenging and is frequently only done post-mortem. Culture diagnosis is best achieved with tissue (valve or biopsy), since blood culture is frequently negative. Any cardiac findings on imaging or physical examination in the context of disseminated aspergillosis suspected by culture, histology or antigen assay should be assumed to be cardiac aspergillosis and investigations for endocarditis should be undertaken. Treatment of cardiac aspergillosis is usually not successful and has not been systematically studied. For endocarditis, surgical and medical therapy are indicated, and medical therapy with either combination amphotericin B and flucytocine or the newer triazoles is suggested. Other forms of cardiac involvement are best managed as disseminated aspergillosis, with a low threshold for diagnosis of endocarditis.

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“…Having rich enzyme systems, they can decompose and use almost all types of organic material, and they can grow even at very low moisture levels compared to other microorganisms. [1] They do not need humans as a host to complete their life cycle, but under appropriate conditions they can become pathogenic in humans. They are a type of fungi present with high density in the air, and they can be carried anywhere by means of conidia that are dispersed in the atmosphere.…”

Section: Introductionmentioning

confidence: 99%

A rare disease mimics postoperative bile leakage: Invasive Aspergillosis

Yazar¹

2015

Ulus Travma Acil Cerrahi Derg

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Aspergillus fungi can cause serious infections, including intra-abdominal infection, particularly in patients with compromised immune system. Described in the present report is case of 46-year-old female patient who had undergone laparoscopic cholecystectomy (LC) at another healthcare facility. In early postoperative period, she had increasing complaints of swelling, nausea, and vomiting. On postoperative 19 th day, she was referred to our clinic with diagnosis of acute abdomen. Surgery was performed with suspected possibility of bile leakage. However, pathological examination of soft, yellow-green mass found in subhepatic space determined it was fungus ball caused by fungi of the genus Aspergillus. Patient was diagnosed postoperative intra-abdominal aspergillosis (IAA).

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Clinical significance of extra-pulmonary involvement of invasive aspergillosis: a retrospective autopsy-based study of 107 patients

Cited by 81 publications

References 26 publications

Acute Lymphocytic Leukemia with Superimposed Invasive Aspergillosis and Pneumopericardium Successfully Treated with Voriconazole

Acute Lymphocytic Leukemia with Superimposed Invasive Aspergillosis and Pneumopericardium Successfully Treated with Voriconazole

Cardiac Aspergillosis

A rare disease mimics postoperative bile leakage: Invasive Aspergillosis

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