Clinical significance of genomic sequencing of circulating tumour cells (CTCs) in cancer

Auwal, Abdul; Hossain, M. Matakabbir; Pronoy, Tasfik Ul Haque; Rashel, K.M.; Nurujjaman, Md; Lam, Alfred KY.; Islam, Farhadul

doi:10.1016/j.jlb.2023.100135

Cited by 2 publications

(1 citation statement)

References 86 publications

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“…High-throughput sequencing of CTC-derived DNA or RNA can allow for a comprehensive genomic and transcriptomic analysis to detect heterogeneous and shared mutational signatures within and between different cancer types [ 171 , 172 ]. This could provide better insight into a patient’s genetic makeup, which in turn can guide clinicians for better disease management.…”

Section: Advancements In Characterizing Ctc Biology and Clinical Impl...mentioning

confidence: 99%

Advancements in Circulating Tumor Cell Research: Bridging Biology and Clinical Applications

Salu,

Reindl

2024

Cancers

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Circulating tumor cells (CTCs) are cells released from the primary and metastatic tumor and intravasate into the blood or lymphatic vessels, where they are transported to distant sites and act as seeds that initiate cancer metastases or the development of further lesions. Recent advances in CTC research have shown their relevance as prognostic markers for early and metastatic disease detection, predictive biomarkers for relapse, and response to medical intervention or therapy. The rapidly evolving landscape of CTC biology has opened new avenues for understanding cancer progression, metastasis, and treatment response. Additionally, translating these findings into clinical applications holds promise for improving cancer diagnostics, prognosis, and personalized therapeutic strategies. This review discusses the significance of CTCs in cancer research and their associated challenges. We explore recent developments in the detection and characterization of CTCs and their implications in cancer research and clinical practice.

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Section: Advancements In Characterizing Ctc Biology and Clinical Impl...mentioning

confidence: 99%

Advancements in Circulating Tumor Cell Research: Bridging Biology and Clinical Applications

Salu,

Reindl

2024

Cancers

View full text Add to dashboard Cite

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Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods

Gromek,

Senkowska,

Płuciennik

et al. 2024

World J Methodol

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In accordance with the World Health Organization data, cancer remains at the forefront of fatal diseases. An upward trend in cancer incidence and mortality has been observed globally, emphasizing that efforts in developing detection and treatment methods should continue. The diagnostic path typically begins with learning the medical history of a patient; this is followed by basic blood tests and imaging tests to indicate where cancer may be located to schedule a needle biopsy. Prompt initiation of diagnosis is crucial since delayed cancer detection entails higher costs of treatment and hospitalization. Thus, there is a need for novel cancer detection methods such as liquid biopsy, elastography, synthetic biosensors, fluorescence imaging, and reflectance confocal microscopy. Conventional therapeutic methods, although still common in clinical practice, pose many limitations and are unsatisfactory. Nowadays, there is a dynamic advancement of clinical research and the development of more precise and effective methods such as oncolytic virotherapy, exosome-based therapy, nanotechnology, dendritic cells, chimeric antigen receptors, immune checkpoint inhibitors, natural product-based therapy, tumor-treating fields, and photodynamic therapy. The present paper compares available data on conventional and modern methods of cancer detection and therapy to facilitate an understanding of this rapidly advancing field and its future directions. As evidenced, modern methods are not without drawbacks; there is still a need to develop new detection strategies and therapeutic approaches to improve sensitivity, specificity, safety, and efficacy. Nevertheless, an appropriate route has been taken, as confirmed by the approval of some modern methods by the Food and Drug Administration.

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Clinical significance of genomic sequencing of circulating tumour cells (CTCs) in cancer

Cited by 2 publications

References 86 publications

Advancements in Circulating Tumor Cell Research: Bridging Biology and Clinical Applications

Advancements in Circulating Tumor Cell Research: Bridging Biology and Clinical Applications

Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods

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