Clinical Significance of Hepatitis C Virus Genotypes

Zein, Nizar N.

doi:10.1128/cmr.13.2.223

Cited by 299 publications

(183 citation statements)

References 134 publications

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“…Genotype 6 has only been found in Southeast Asia. Initially, genotype 5 was thought to be confined to South Africa (1,2), where it has been observed in up to 30% of HCV infections (3). Recent reports have shown that in fact genotype 5 has a worldwide distribution but, except in South Africa, is always a minor component of the HCV population.…”

mentioning

confidence: 99%

Hepatitis C Virus Genotype 5 in Southern Belgium: Epidemiological Characteristics and Response to Therapy

Delwaide

Gérard²,

Reenaers

et al. 2005

Dig Dis Sci

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Data are scarce on patients infected with hepatitis C virus of genotype 5, due to the low prevalence of this genotype around the world. To better define the characteristics of these patients, we reviewed the files of 16 genotype 5 patients. Mean age was 38 +/- 14. All patients were of European origin. Most of them (75%) had been contaminated by transfusion within a short time period (between 1980 and 1991). There were no intravenous drug addicts. Seven patients received treatment. One patient did not respond to interferon (IFN) monotherapy. Of four patients treated with IFN and ribavirin, three became sustained viral responders. Two patients treated with pegylated IFN and ribavirin became sustained viral responders. In our region, genotype 5 patients seem to have been contaminated within a relatively short time period. Treatment with IFN or pegylated IFN and ribavirin gave a high rate (83%) of sustained viral responses.

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mentioning

confidence: 99%

Hepatitis C Virus Genotype 5 in Southern Belgium: Epidemiological Characteristics and Response to Therapy

Delwaide

Gérard²,

Reenaers

et al. 2005

Dig Dis Sci

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“…For instance, genotype 4 is found mainly in the Middle East and North Africa, genotype 5 in southern and central Africa, and genotype 6 in Asia. Although HCV subtypes 2a and 2b are relatively common in North America, Europe, and Japan, subtype 2c has been reported as prevailing in northern Italy [2,3]. In central and northern Europe, genotype 2 has a low prevalence (2%-7%), whereas frequency of genotype 3 amounts to 17%.…”

Section: Epidemiologic Aspectsmentioning

confidence: 99%

“…Comparison of the nucleotide sequence of variants recovered from infected individuals in different risk groups and from different geographic regions has revealed the existence of several genetic groups, called genotypes. Based on differences in HCV RNA sequence, six major genotypes and approximately 100 HCV subtypes have been classified [2][3][4]. Although the natural history of the disease seems to be independent of this viral genetic heterogeneity, genotypes do correlate with the treatment response.…”

Section: Introductionmentioning

confidence: 99%

Are HCV genotypes 2 and 3 the same or different?

Mangia

Andriulli

2008

Curr hepatitis rep

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“…Genotype 3a is most common among American and European intravenous drug users. Genotype 4 tends to be most common in North Africa and the Middle East, while genotypes 5 and 6 are confined to mainly South Africa and Southeast Asia respectively [37]. HCV genotyping is the most predictive parameter used in defining antiviral therapy response rate.…”

Section: Genotypementioning

confidence: 99%

Management of patients with chronic hepatitis C infection

2006

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Chronic infection with hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality throughout the world. Although reliable figures regarding the global prevalence of HCV infection are wanting, it is likely that HCV prevalence will continue to increase. Injection drug use is the most important source of HCV transmission in the developed world, while unsafe therapeutic injection is an important source of transmission in developing nations. The majority of exposed individuals become chronically infected, of whom 50% develop chronic liver injury. Cirrhosis and hepatocellular carcinoma can arise in those chronically infected over a mean of 20-30 years. Despite this high prevalence and morbidity, recommendations regarding who to screen by antibody testing remain disparate. Quantitative measurement of HCV RNA and HCV genotyping is useful in predicting response to antiviral therapy. Noninvasive methods of detecting liver injury, such as serologic batteries, have not been as informative or predictable as liver biopsy. The current pharmacologic standard of care for chronic HCV infection is the combination of subcutaneous peginterferon and oral ribavirin, which yields sustained virologic response in 54%-56%. Higher rates of SVR are seen in those patients who are infected with HCV genotypes 2 and 3. As intravenous drug use remains the most important source of HCV transmission in the US and Europe, education within this group is an important preventive tool.

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Clinical Significance of Hepatitis C Virus Genotypes

Cited by 299 publications

References 134 publications

Hepatitis C Virus Genotype 5 in Southern Belgium: Epidemiological Characteristics and Response to Therapy

Hepatitis C Virus Genotype 5 in Southern Belgium: Epidemiological Characteristics and Response to Therapy

Are HCV genotypes 2 and 3 the same or different?

Management of patients with chronic hepatitis C infection

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