Clinical Significance of Herpes Simplex Virus in the Lower Respiratory Tract of Critically Ill Patients

Camps, K.; Jorens, Philippe G.; Demey, Hendrik E.; Pattyn, S.; Ieven, Margareta

doi:10.1007/s10096-002-0809-y

Cited by 24 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results were in line with those of the sensitivity analyses (Supplementary Fig. 1 B and C, Supplementary Table 3 ; ICU all-cause mortality including [ 17 ]: RR 0.75 [0.57, 1.00], I 2 = 56.5% with p = 0.06).…”

Section: Resultssupporting

confidence: 88%

“…For the primary endpoint, hospital all-cause mortality, data from eight studies comprising 831 patients were used (Fig. 2 a) [ 5 , 7 , 11 , 17 , 26 , 27 , 29 , 31 ]. In these studies, hospital all-cause mortality was lower in patients with antiviral therapy (40.6%, 189 out of 465 patients) than in patients without antiviral therapy (52.7%, 193 out of 366 patients).…”

Section: Resultsmentioning

confidence: 99%

“…independently validated the results. One study [ 17 ] reported mortality; however, it did not specify the timepoint. We decided to include this article and classified it as hospital all-cause mortality.…”

Section: Methodsmentioning

confidence: 99%

“…To identify potential evidence of publication bias, we additionally inspected funnel plots. For the sensitivity analyses, we (i) performed the meta-analysis with odds ratios (ORs) as a measure of effect size, (ii) applied leave-one-out cross-validation and (iii) assumed that mortality reported in [ 17 ] was ICU all-cause mortality. We reported point estimates (RR or OR) together with their corresponding 95% confidence intervals (CIs) and presented the results as forest plots.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Effect of antiviral therapy on the outcomes of mechanically ventilated patients with herpes simplex virus detected in the respiratory tract: a systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

Background Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients. The aim of this study was to assess current evidence to determine whether antiviral therapy is associated with better outcomes in these patients. Methods MEDLINE, ISI Web of Science, Cochrane Database and ClinicalTrials.gov were searched from inception to 25 May 2020. All clinical studies investigating the effects of antiviral therapy on the outcome of mechanically ventilated ICU patients in whom HSV was detected in the respiratory tract were eligible for inclusion, regardless of study design, publication status or language. Titles and abstracts were reviewed independently by two authors. If the articles seemed eligible, full-text articles were reviewed and data extracted. We performed a random-effects meta-analysis to estimate relative risks (RRs) with corresponding 95% confidence intervals (CIs). The primary endpoint was hospital all-cause mortality. Results Nine studies were included in the meta-analysis (one randomized controlled trial, eight cohort studies). Antiviral treatment was associated with lower hospital mortality (with antiviral treatment, 40.6% (189 out of 465 patients); without, 52.7% (193 out of 366 patients); RR 0.74 [0.64, 0.85]; eight studies, low quality of evidence). Furthermore, antiviral treatment was associated with lower 30-day mortality (RR 0.75 [0.59, 0.94]; three studies, very low quality of evidence). We did not observe evidence for differences in ICU mortality (RR 0.73 [0.51, 1.05]; three studies, very low quality of evidence). Conclusions This meta-analysis of the available data shows that antiviral therapy might result in lower hospital and 30-day all-cause mortality in mechanically ventilated ICU patients who are positive for HSV in the respiratory tract. However, this result must be interpreted with great caution due to the high risk of bias and limited number of patients. Large, well-designed randomized controlled clinical trials are urgently needed. Trial registration The study was registered in advance on International Prospective Register of Systematic Reviews (CRD42020180053).

show abstract

Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Effect of antiviral therapy on the outcomes of mechanically ventilated patients with herpes simplex virus detected in the respiratory tract: a systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A randomized control trial showed acyclovir treatment can prevent HSV reactivation, but appears to have no effect on survival or duration of mechanical ventilation (174, 175). Clinically severe or symptomatic cutaneous HSV or herpes zoster reactivations are usually treated with acyclovir once diagnosis is confirmed (176).…”

Section: Virusesmentioning

confidence: 99%

Resistant Pathogens, Fungi, and Viruses

Guidry

Mansfield

Sawyer

et al. 2014

Surgical Clinics of North America

View full text Add to dashboard Cite

The first reports of antibiotic pathogens occurred a few short years after the introduction of these powerful new agents, heralding a new kind of war between medicine and pathogens. Although originally described in Staphylococcus aureus, resistance among bacteria has now become a grim race to determine which classes of bacteria will become more resistant, pitting the Gram positive staphylococci, enterococci, and streptococci against the increasingly resistant Gram negative pathogens, e. g., carbapenemase-resistant enterobacteriaceae. In addition, the availability of antibacterial agents has allowed the development of whole new kinds of diseases caused by non-bacterial pathogens, related largely to fungi that are inherently resistant to antibacterials. All of these organisms are becoming more prevalent and, ultimately, more clinically relevant for surgeons. It is ironic that despite their ubiquity in our communities, there is seldom a second thought given to viral infections in patients with surgical illness. The extent of most surgeon’s interest in viral infections ends with hepatitis and HIV, no doubt related to transmissibility as well as the implications that these viruses might have in a patient’s hepatic or immune functions. There are chapters and even textbooks written about these viruses so these will not be considered here. Instead, we will present the growing body of knowledge of the herpes family viruses and their occurrence and consequences in patients with concomitant surgical disease or critical illness. We have also chosen to focus this chapter on previously immune competent patients, as the impact of herpes family viruses in immunosuppressed patients such as transplant or AIDS patients has received thorough treatment elsewhere.

show abstract

Herpes simplex virus lower respiratory tract infection in patients with solid tumors

Aisenberg

Torres

Tarrand

et al. 2008

Cancer

View full text Add to dashboard Cite

We have recently introduced a novel model for discriminating the correctly folded proteins from well‐designed decoy structures using mechanical interatomic forces. In the model, we considered a protein as a collection of springs and the force imposed to each atom was calculated by using the relation between the potential energy and the force. A mean force potential function is obtained from statistical contact preferences within the known protein structures. In this article, the interatomic forces are calculated by numerical derivation of the potential function. For assessing the knowledge‐based force function we consider an optimal structure and define a score function on the 3D structure of a protein. We compare the force imposed to each atom of a protein with the corresponding atom in the optimum structure. Afterwards we assign larger scores to those atoms with the lower forces. The total score is the sum of partial scores of atoms. The optimal structure is assumed to be the one with the highest score in the dataset. Finally, several decoy sets are applied in order to evaluate the performance of our model. Proteins 2012. © 2012 Wiley Periodicals, Inc.

show abstract

Clinical Significance of Herpes Simplex Virus in the Lower Respiratory Tract of Critically Ill Patients

Cited by 24 publications

References 11 publications

Effect of antiviral therapy on the outcomes of mechanically ventilated patients with herpes simplex virus detected in the respiratory tract: a systematic review and meta-analysis

Effect of antiviral therapy on the outcomes of mechanically ventilated patients with herpes simplex virus detected in the respiratory tract: a systematic review and meta-analysis

Resistant Pathogens, Fungi, and Viruses

Herpes simplex virus lower respiratory tract infection in patients with solid tumors

Contact Info

Product

Resources

About