Clinical Significance of<i>SEC11A</i>Expression in Patients With Locally Advanced Gastric Cancer

Suematsu, Hideaki; Sakamaki, Kentaro; Oue, Naohide; Hiroshima, Yukihiko; Kimura, Yayoi; Onuma, Shizune; Hashimoto, Itaru; Nagasawa, Shinsuke; Aoyama, Toru; Yamada, Takanobu; Tamagawa, Hiroshi; Ogata, Takashi; Rino, Yasushi; Masuda, Munetaka; Yasui, Wataru; Miyagi, Yohei; Oshima, Takashi

doi:10.21873/anticanres.16097

Anticancer Res

2022

DOI: 10.21873/anticanres.16097

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Clinical Significance ofSEC11AExpression in Patients With Locally Advanced Gastric Cancer

Hideaki Suematsu

Kentaro Sakamaki

Naohide Oue

et al.

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2024

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Characterization of mitochondrial metabolism related molecular subtypes and immune infiltration in colorectal adenocarcinoma

Wang,

Xue,

Fei

et al. 2024

Sci Rep

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Colorectal adenocarcinoma (COAD) is the most common subtype of colorectal cancer. Due to the imperfect prognosis of COAD, related prognostic factors and possible mechanisms need to be further investigated. During tumor development, mitochondria help tumor cells survive in a variety of ways, so that further screening of mitochondrial metabolism related targets has positive implications for COAD. We screened the mitochondrial metabolism-related genes (MMRG) associated with the COAD prognosis and explored the MMRG-related molecular subtype characteristics of by unsupervised consensus clustering analysis. Using ESTIMATE and ssGSEA algorithms, we evaluated the immunoinfiltration characteristic landscape of different molecular subtypes defined by MMRG. Combining the expression profiles of differentially expressed genes associated with the MMRG subgroup and the survival characteristics of COAD, we constructed an MMRG prognostic model using LASSO-univariate Cox analysis and successfully validated its impact on independently predicting risk stratification of COAD. The potential clinical value of the MMRG score was subsequently evaluated by subgroup immunoinfiltration characteristics and drug susceptibility prediction analysis. We also offer SEC11A as a new potential target for COAD by single-cell sequencing analysis. The effect of SEC11A on the proliferation, invasion abilities and mitochondrial dysfunction of COAD cells was confirmed through in vitro experiments. Our study provides new insights into the role of MMRG and new target for COAD potential intervention. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-75482-2.

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Characterization of mitochondrial metabolism related molecular subtypes and immune infiltration in colorectal adenocarcinoma

Wang,

Xue,

Fei

et al. 2024

Sci Rep

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Clinical Significance ofSEC11AExpression in Patients With Locally Advanced Gastric Cancer

Cited by 1 publication

References 0 publications

Characterization of mitochondrial metabolism related molecular subtypes and immune infiltration in colorectal adenocarcinoma

Characterization of mitochondrial metabolism related molecular subtypes and immune infiltration in colorectal adenocarcinoma

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