Clinical significance of immunopathological mechanisms in diseases of the nervous system

Abstract

The clinical applications of immunology in neurology are reviewed in relation to autoimmunity, immunosuppression, brain tumour immunity and the transplantation of peripheral nervous tissue. Evidence for considering the role of immunological factors in certain neurological diseases is considered. The clinical value of immunosuppressive therapy in these diseases is discussed. Attention is drawn to immunotherapy as a possible adjunct to present methods of treating gliomas. Finally, possible uses of transplants of peripheral nerve and muscle are mentioned.

An Immunofluorescence Study of the Passive Arthus Reaction in Rat Sciatic Nerve

“…Immunological factors are known to play a n important role i n several neurological diseases, and the pathological significance of this role in disorders of the peripheral and central nervous system has previously been reviewed (Ridley, 1971). In most neurological diseases studied so far, research has centred on abnormal delayedtype hypersensitivity rather than antibody mediated hypersensitivity.…”