Clinical significance of integrin β6 as a tumor recurrence factor in follicular thyroid carcinoma

Zhang, Zhuang; Xu, Zicheng; Zhou, Qian; Xu, Xiequn; Tian, Jessie; Liu, Yanfeng; Guo, Shu; Wang, Jiayong; Xu, Kesen

doi:10.1002/hed.23780

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…Several studies in cell models and primary tumors demonstrated the biological role and potential clinical impact of integrins in thyroid tumors. Expression of integrin subunit β4 correlates with lymph node metastasis in papillary carcinomas, and integrin subunit β6 significantly correlates with recurrence of follicular thyroid carcinoma (FTC) [18,19]. Inhibition of α5β1 binding to ECM prevents attachment of FTC cell lines to the bone matrix [20], while RET-induced cell adhesion and migration of papillary thyroid carcinoma (PTC) cell lines required β1 and β3 integrins in vitro and in a mouse tumor xenograft model [21].…”

Section: Introductionmentioning

confidence: 99%

Higher Integrin Alpha 3 Beta1 Expression in Papillary Thyroid Cancer Is Associated with Worst Outcome

Mautone

Ferravante

Tortora

et al. 2021

Cancers

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Integrins are cell-extracellular matrix adhesion molecules whose expression level undergoes quantitative changes upon neoplastic transformation and are considered functionally related to the development of cancer metastasis. We analyzed the largest mRNA-seq dataset available to determine the expression pattern of integrin family subunits in papillary thyroid carcinomas (PTC). ITGA2, 3, 6, V, and ITGB1 integrin subunits were overexpressed in PTC compared to normal thyroid tissue. The PTC histology variants “classical” and “tall cell” displayed a similar integrin expression profile with a higher level of ITGA3, ITGAV, and ITGB1, which differed from that of the “follicular” variant. Interestingly, compared to RAS mutations, BRAFV600E mutation was associated with a significantly higher expression of integrins. Some integrin subunits were associated with advanced disease stage, lymph node metastasis, extrathyroidal extension, and high-risk groups. Among them, ITGA3 expression displayed the highest correlation with advanced disease and was associated with a negative prognosis. In vitro scratch assay and Matrigel invasion assay in two different PTC cell lines confirmed α3β1 role in cell motility and invasion, supporting its involvement during tumor progression. These results demonstrate the existence of a PTC-specific integrin expression signature correlated to histopathology, specific driver gene mutations, and aggressiveness of the disease.

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Section: Introductionmentioning

confidence: 99%

Higher Integrin Alpha 3 Beta1 Expression in Papillary Thyroid Cancer Is Associated with Worst Outcome

Mautone

Ferravante

Tortora

et al. 2021

Cancers

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Synergistic cytotoxicity of the dipeptidyl peptidase-IV inhibitor gemigliptin with metformin in thyroid carcinoma cells

et al. 2017

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Our results demonstrate that gemigliptin induces cytotoxic activity, and has a synergistic activity with metformin in inducing cytotoxicity via regulation of Akt and AMPK in thyroid carcinoma cells. Furthermore, gemigliptin augments the inhibitory effect of metformin on proliferation and migration through involvement of matrix metalloproteinase-2, matrix metalloproteinase-9, p53, p21, VCAM-1, and ERK in thyroid carcinoma cells.

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Integrin alpha 7 correlates with poor clinical outcomes, and it regulates cell proliferation, apoptosis and stemness via PTK2-PI3K-Akt signaling pathway in hepatocellular carcinoma

Wang

Chen

et al. 2020

Cellular Signalling

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Clinical significance of integrin β6 as a tumor recurrence factor in follicular thyroid carcinoma

Abstract: Integrin β6 expression correlated significantly with MMP-9 expression, and may be a valuable recurrence indicator for follicular thyroid carcinomas.

Cited by 4 publications

References 35 publications

Higher Integrin Alpha 3 Beta1 Expression in Papillary Thyroid Cancer Is Associated with Worst Outcome

Higher Integrin Alpha 3 Beta1 Expression in Papillary Thyroid Cancer Is Associated with Worst Outcome

Synergistic cytotoxicity of the dipeptidyl peptidase-IV inhibitor gemigliptin with metformin in thyroid carcinoma cells

Integrin alpha 7 correlates with poor clinical outcomes, and it regulates cell proliferation, apoptosis and stemness via PTK2-PI3K-Akt signaling pathway in hepatocellular carcinoma

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