Clinical Significance of International Union Against Cancer pN Staging and Lymph Node Ratio in Node-Positive Colorectal Cancer after Advanced Lymph Node Dissection

Märkl, Bruno; Olbrich, G; Schenkirsch, Gerhard; Kretsinger, Hallie; Kriening, Bernadette; Anthuber, Matthias

doi:10.1097/dcr.0000000000000569

Cited by 10 publications

(14 citation statements)

References 38 publications

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“…Clinicopathological data, including sex, age, tumor size, tumor-node-metastasis (TNM) stage and lymph node involvement, were retrospectively analyzed. Staging and grading of the CRC were performed according to the World Health Organization classification and the Union for International Cancer Control (29). Survival time was defined as the time between surgery and the time of the last follow-up day, or patient mortality.…”

Section: Methodsmentioning

confidence: 99%

MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer

et al. 2019

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The aim of the present study was to research the mechanism of action of microRNA-144 (miR-144) in colorectal cancer (CRC) and its role in tumor progression. It was demonstrated that miR-144 was downregulated and anoctamin 1 (ANO1) expression was upregulated in CRC. The expression of ANO1 was negatively associated with that of miR-144 in CRC. The present study indicated that upregulated expression of ANO1 was associated with poor differentiation and advanced tumor-node-metastasis stage. It was verified that upregulation of ANO1 expression activated the epidermal growth factor receptor/extracellular signal-regulated kinase signaling pathway. It was also demonstrated that miR-144 exerts strong tumor-inhibiting effects by targeting ANO1. Therefore, miR-144 may have potential as a prognostic marker or therapeutic target for CRC.

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Section: Methodsmentioning

confidence: 99%

MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer

et al. 2019

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“…Among these parameters, the pN stage is only evaluated by the number of involved regional lymph nodes (LNs) in colorectal cancer (CRC) [1]. In CRC, a patient with regional LN metastasis is classified as stage III, in which adjuvant chemotherapy treatment is generally recommended [1,2,3]. Therefore, the detection of nodal status is essential for the decision of treatment modality and prediction of prognosis.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Implication of Metastatic Lymph Node Ratio in Colorectal Cancers: Comparison Depending on Tumor Location

Pyo

Shin

Kang

2019

JCM

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Background: The proportion of the number of involved lymph nodes (LNs) to the number of examined LNs—defined as metastatic LN ratio (mLNR)—has been considered as a prognostic parameter. This study aims to elucidate the prognostic implication of the mLNR in colorectal cancer (CRC) according to the tumor location. Methods: We evaluated the correlation between prognoses and the involved and examined LNs as well as mLNR according to the tumor location in 266 surgically resected human CRCs. Besides, to evaluate the optimal cutoff for high and low mLNRs, we investigated the correlation between mLNR and survival according to the various cutoffs. Results: LN metastasis was found in 146 cases (54.9%), and colon and rectal cancers were found in 116 (79.5%) and 30 (20.5%) of the cases, respectively. The mean mLNRs were significantly higher in rectal cancer than in colon cancer (0.38 ± 0.28 vs. 0.21 ± 0.24, P = 0.003). Besides this, the number of involved LNs in rectal cancer was significantly high compared to colon cancer (11.83 ± 10.92 vs. 6.37 ± 7.78, P = 0.014). However, there was no significant difference in the examined LNs between the rectal and colon cancers (31.90 ± 12.28 vs. 36.60 ± 18.11, P = 0.181). In colon cancer, a high mLNR was significantly correlated with worse survival for all cutoffs (0.1, 0.2, 0.3, and 0.4). However, rectal cancer only showed a significant correlation between high mLNR and worse survival in the subgroup with a cutoff of 0.2. Conclusions: Our results showed that high mLNR was significantly correlated with worse survival. The number of involved LNs and mLNRs were significantly higher in rectal cancer than in colon cancer. The cutoff of 0.2 can be useful for the differentiation of prognostic groups, regardless of tumor location.

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“…[5][6][7] Ex vivo intra-arterial lymph node staining increases the number of identified nodes after colorectal cancer surgery. [8][9][10][11][12][13][14] Instead of the commonly used methylene blue, we used indigo carmine (IC) for staining, which seems to be less mutagenic when used in vivo. 15 Little is known about the effect of ex vivo staining of rectal cancer specimens after neoadjuvant therapy.…”

mentioning

confidence: 99%

“…Ex vivo intra-arterial lymph node staining increases the number of identified nodes after colorectal cancer surgery. 8–14 Instead of the commonly used methylene blue, we used indigo carmine (IC) for staining, which seems to be less mutagenic when used in vivo. 15…”

mentioning

confidence: 99%

Advanced Lymph Node Staging With Ex Vivo Intra-arterial Indigo Carmine Injection After Transanal Total Mesorectal Excision for Rectal Cancer: A Retrospective Cohort Study

Widmann

Almarie

Warschkow

et al. 2022

Diseases of the Colon &Amp; Rectum

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Clinical Significance of International Union Against Cancer pN Staging and Lymph Node Ratio in Node-Positive Colorectal Cancer after Advanced Lymph Node Dissection

Abstract: pN staging proved to be a robust prognostic marker in colorectal cancer under the circumstances of improved lymph node harvest. After adaptation of the cutoff values, lymph node ratio is also prognostic but not superior to pN staging.

Cited by 10 publications

References 38 publications

MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer

MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer

Prognostic Implication of Metastatic Lymph Node Ratio in Colorectal Cancers: Comparison Depending on Tumor Location

Advanced Lymph Node Staging With Ex Vivo Intra-arterial Indigo Carmine Injection After Transanal Total Mesorectal Excision for Rectal Cancer: A Retrospective Cohort Study

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