Clinical significance of intra-nodal naevi in sentinel node biopsies for malignant melanoma

Smith, Oliver J.; Coelho, James; Trevatt, Alexander; Ross, Gary

doi:10.1016/j.ejso.2016.04.057

Cited by 11 publications

(39 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Melanoma patients with INN are treated as negative SLNB patients due to the believed benign character of INN, underlined by immunohistological studies describing similarities between INN cells and benign cutaneous melanocytes . Only three previous studies discuss the clinical significance of INN in the SLNB in patients with primary cutaneous melanoma . Similar to our results, Gambichler et al .…”

Section: Discussionsupporting

confidence: 86%

“…described a significant association between the presence of INN and cutaneous melanoma localization on the trunk and upper limbs, the lower extremities being the strongest negative predictor of INN . Smith et al . showed a comparable association but the difference was not significant.…”

Section: Discussionmentioning

confidence: 95%

“…Gamblicher et al . reported that females had more often INN, while Smith et al . reported the opposite.…”

Section: Discussionmentioning

confidence: 97%

“…Our relatively low prevalence could partly be explained by the retrospective nature of our study as we extracted all information on the SLNB from text files, assuming INN not to be present if not reported in the text files. Most previous studies provided single‐centred data, where the same pathologists observed the histology of the SLNB, perhaps resulting in more awareness for INN . INN mostly occur in the capsule or trabeculae of the lymph node, but in rare cases INN occur in the parenchyma of the lymph node which is similar to the location of metastatic melanoma .…”

Section: Discussionmentioning

confidence: 99%

“…Patients diagnosed with INN (and without nodal melanoma metastasis) are treated as SLNB‐negative patients in current practice. Only few studies have reported the clinical significance of INN and discuss the consequences of potential misdiagnoses …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Intra‐nodal nevi in sentinel node‐negative patients with cutaneous melanoma does not influence survival

Beer

Diest

Sigurdsson

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

Background Melanoma patients with intra‐nodal nevi (INN) and without melanoma metastasis in the sentinel lymph node biopsy (SLNB) are generally treated as patients with negative SLNB. However, diagnosis of INN may be difficult and nodal melanoma metastases may falsely be regarded as INN. Objectives Our aim was to evaluate the clinical significance of INN in the SLNB in patients with primary cutaneous melanoma on a nationwide level in The Netherlands by comparing survival between three groups: patients with INN and without nodal melanoma metastasis (INN group), patients without INN and without nodal melanoma metastasis (negative SLNB group) and patients with nodal melanoma metastasis irrespective of INN (positive SLNB group). Methods Data were obtained from ‘PALGA’, the Dutch Nationwide Network and Registry of Histopathology and Cytopathology, yielding a cohort of adults with histologically proven, primary, invasive cutaneous melanoma patients in The Netherlands diagnosed between 2000 and 2014 who underwent SLNB. Clinical and pathological variables were extracted from the pathology text files. Differences between patients with INN, negative SLNB and positive SLNB were analysed using Kaplan–Meier analysis. Results A total of 11 274 patients were eligible for inclusion. The prevalence of INN in the SLNB was 5.0%. Melanomas with INN had similar median Breslow thickness compared to melanomas with negative SLNB and were more frequently located on trunk and upper limbs and observed in younger patients compared to melanomas with negative and positive SLNB. Overall survival of patients with INN showed no significant difference compared with negative SLNB (median follow‐up of 5.7 years of all patients). Conclusions As there seems to be no difference in overall survival between patients with INN and negative SLNB, the diagnosis of INN seems to be reliable. Current practice to treat patients with INN as patients with negative SLNB appears to be appropriate.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 95%

“…Gamblicher et al . reported that females had more often INN, while Smith et al . reported the opposite.…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Intra‐nodal nevi in sentinel node‐negative patients with cutaneous melanoma does not influence survival

Beer

Diest

Sigurdsson

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

Clinical significance of SLN benign capsular nevi in patients with melanoma

Yamashita

Pockaj

Bagaria

et al. 2020

Journal of Surgical Oncology

View full text Add to dashboard Cite

Background: Benign capsular nevi (BCN) are not infrequent in sentinel lymph nodes (SLN) of patients with melanoma. Their prognostic significance is unknown and the literature is limited. This study evaluated the clinical significance of incidentally found BCN in these patients. Methods: A multi-institutional retrospective review of patients undergoing SLN biopsy for cutaneous melanoma between 2000 and 2016. Patients were divided into the following groups: (a) negative SLN and no BCN, (b) negative SLN and presence of BCN, (c) positive SLN seen only on immunohistochemistry (IHC), and (d) positive SLN via hematoxylin and eosin (H&E). Outcomes measured were overall survival and any recurrence. Results: A total of 1253 patients were identified (group 1 = 978, group 2 = 56, group 3 = 32, and group 4 = 187). Fifty-seven percent were male and the mean age was 59.3 years. BCN was identified in 77 patients (6.2%), of which the majority was in the node-negative group (72%). Multivariable analysis showed that BCN was associated with lower recurrence rates, though not statistically significant (hazard ratio [HR] = 0.5; P = .06). IHC-and H&E-positive SLNs were associated with a higher risk of recurrence (HR = 2.4; P = .02 and 2.0, P < .0001, respectively). Conclusion: Patients with BCN and negative SLN had lower recurrence rates than patients with negative SLN and no BCN. Our data suggest a possible protective effect against recurrence.

show abstract

Melanocytic nevi in sentinel lymph nodes: association with cutaneous nevi and clinical relevance in patients with cutaneous melanomas

Kretschmer

Schnabel

Kromer

et al. 2022

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

Purpose Melanocytic nevi in lymph nodes (NNs) are an important histological differential diagnosis of initial sentinel lymph node (SN) metastasis in melanoma. Our aim was to associate NN in SNs with clinicopathologic features and survival rates in 1, 250 patients with SN biopsy for melanoma. Methods To compare patients with present and absent NN, we used Fisher's exact test, Mann–Whitney U test, and multivariate logistic regression models in this retrospective observational study based on a prospectively maintained institutional database. Results NN prevalence in axillary, cervical, and groin SNs was 16.5%, 19.4%, and 9.8%, respectively. NN were observed in combination with all growth patterns of melanoma, but more frequently when the primary was histologically associated with a cutaneous nevus. We observed a decreasing NN prevalence with increasing SN metastasis diameter. Multiple logistic regression determined a significantly increased NN probability for SNs of the neck or axilla, for individuals with ≥ 50 cutaneous nevi, midline primary melanomas, and for individuals who reported non-cutaneous malignancies in their parents. Cancer in parents was also significantly more frequently reported by melanoma patients who had more than 50 cutaneous nevi. In SN-negative patients, NN indicated a tendency for slightly lower melanoma-specific survival. Conclusions We found a highly significant association between NN diagnosis and multiple cutaneous nevi and provided circumstantial evidence that cutaneous nevi in the drainage area of lymph nodes are particularly important. The trend toward lower melanoma-specific survival in SN-negative patients with NN suggests that careful differentiation of SN metastases is important.

show abstract

Clinical significance of intra-nodal naevi in sentinel node biopsies for malignant melanoma

Abstract: We have clinically demonstrated that patients with INN on SNB can be adequately treated as SNB negative patients.

Cited by 11 publications

References 29 publications

Intra‐nodal nevi in sentinel node‐negative patients with cutaneous melanoma does not influence survival

Intra‐nodal nevi in sentinel node‐negative patients with cutaneous melanoma does not influence survival

Clinical significance of SLN benign capsular nevi in patients with melanoma

Melanocytic nevi in sentinel lymph nodes: association with cutaneous nevi and clinical relevance in patients with cutaneous melanomas

Contact Info

Product

Resources

About