Clinical significance of intramammary arterial calcifications in diabetic women

Milošević, Zorica; Bjekić, Jelica; Radulovic, Stanko; Goldner, Branislav

doi:10.2298/vsp0402163m

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…Some studies show a significant association between BAC and hypertension, 19,32,33 whereas others show no such association. 4,24,34 Similarly, with diabetes mellitus, some studies show a statistically significant association, 6,19,35,36 whereas others show none. 4,24,37,38 …”

Section: Discussionmentioning

confidence: 98%

Mammographically Detectable Breast Arterial Calcification and Atherosclerosis

Shah

Chainani

Delafontaine

et al. 2014

Cardiology in Review

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Breast arterial calcification (BAC), observed as an incidental finding on screening mammograms, represents degenerative calcific changes occurring in the mammary arteries, with increasing age. The aim of this review is to discuss relevant literature examining relation between BAC and atherosclerosis. After a thorough literature search, in OVID and PubMed, 199 studies were identified, of which 25 were relevant to our review. Data were abstracted from each study and statistical analysis was done, including calculation of odds ratios and construction of forest plots. A total of 35,542 patients were enrolled across 25 studies looking at an association between BAC and coronary artery disease, cardiovascular disease, stroke, cerebral artery disease, carotid and peripheral artery diseases, and coronary artery calcification. A majority of the studies showed a statistically significant relation between BAC and presence of coronary artery disease cardiovascular disease and associated mortality. Sensitivity of BAC in predicting cardiovascular events was low, but specificity was high. BAC was predictive of incident and prevalent stroke but not mortality of stroke. Similarly, BAC was predictive of cerebral, carotid, and peripheral artery diseases. The role of BAC as a surrogate marker of coronary and systemic atherosclerosis is currently uncertain. Its role may be further elucidated by more large-scale prospective studies and clinical experience.

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Section: Discussionmentioning

confidence: 98%

Mammographically Detectable Breast Arterial Calcification and Atherosclerosis

Shah

Chainani

Delafontaine

et al. 2014

Cardiology in Review

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“…In turn, Çetin et al 47 showed a 4-fold higher prevalence of BAC among patients with DM, suggesting BAC could be used to screen for DM in women aged ≥60 years. Similarly, Milosević et al 52 showed that BAC was found in 33.3% of type 1 DM, 40.2% of type 2 DM, and 8.2% of nondiabetics ( P = .0001). Age was not a significant covariable for the association between BAC and type 2 DM analysis, but there was a significant association between BAC and type 1 DM, especially in younger women ( P for trend = .001).…”

Section: Diabetes Mellitus and Bacmentioning

confidence: 80%

Can Incidental Vascular Calcifications at Mammography be Used as a Screening Biomarker for Heart and Kidney Disease?

et al. 2018

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Mammography is a screening test with extensive international application and financial infrastructure promoting accessibility and affordability. Designed specifically to detect microcalcifications, mammography is powered to detect calcifications in vessel walls. Breast arterial calcifications (BAC) are one of the most common incidental findings documented by mammography. This review considers the literature regarding BAC in relation to cardiovascular disease (CVD) and its risk factors. The aim is to assess the possibility of using BAC as an early surrogate imaging biomarker of CVD.

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“…De manera similar, Milosevic et al expusieron que se encontraron calcificaciones vasculares en el 40.2% en las mamografías de pacientes diabéticas y el 8.2% en las mamografías de las paciones no diabéticas. La edad no fue una covariable significativa para la asociación entre calcificaciones vasculares intramamarias y diabetes mellitus tipo 2 13 . Debido a los estudios con resultados mixtos no se ha llegado a un consenso sobre la relación de la diabetes mellitus y las calcificaciones vasculares mamarias, ya que también se visualiza en pacientes de edad avanzada.…”

Section: Introductionunclassified

Calcificaciones vasculares en mamografía y su relación con enfermedades metabólicas

González-Morales,

Onofre-Castillo,

Cuituny-Romero

2023

ARM

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Determinar si existe asociación entre la presencia de calcificaciones vasculares detectadas en mamografías de tamizaje y la presencia de diabetes mellitus que permitirá sugerir pruebas diagnósticas confirmatorias. Material y métodos: Se incluyeron los resultados de los estudios realizados a pacientes que acudieron a cita para valoración por el departamento de check up que contaban con mamografía, y con expediente clínico completo dentro del periodo de octubre de 2018 hasta octubre de 2019. Se determinó la asociación utilizando las herramientas de medidas de tendencia central, razón de momios y chi cuadrada. Resultados: El 23% de las pacientes diabéticas incluidas en el estudio presentó calcificaciones vasculares por mamografía. Las pruebas de chi cuadrada para la diabetes mellitus, hipertensión arterial, obesidad y dislipidemia fueron 0.405 (p = 0.52), 1.23 (p = 0.26), 0.765 (p = 0.38) y 0.326 (p = 0.56) respectivamente. Conclusiones: No se pudo comprobar una asociación estadísticamente significativa entre la presencia de calcificaciones vasculares en mamografía y la presencia de enfermedades metabólicas.

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Clinical significance of intramammary arterial calcifications in diabetic women

Abstract: The obtained results supported the theory that intramammary arterial calcifications, detected by mammography, could serve as markers of co-existing diabetes mellitus and therefore should be specified in radiologic report in case of their early development.

Cited by 4 publications

References 4 publications

Mammographically Detectable Breast Arterial Calcification and Atherosclerosis

Mammographically Detectable Breast Arterial Calcification and Atherosclerosis

Can Incidental Vascular Calcifications at Mammography be Used as a Screening Biomarker for Heart and Kidney Disease?

Calcificaciones vasculares en mamografía y su relación con enfermedades metabólicas

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