Clinical Significance of Lifetime Panic Spectrum Symptoms in the Treatment of Patients With Bipolar I Disorder

Frank, Ellen; Cyranowski, Jill M.; Rucci, Paola; Shear, M. Katherine; Fagiolini, Andrea; Thase, Michael E.; Cassano, Giovanni B.; Grochocinski, Victoria J.; Kostelnik, Bryan; Kupfer, David J.

doi:10.1001/archpsyc.59.10.905

Cited by 165 publications

(119 citation statements)

References 35 publications

Supporting

Mentioning

106

Contrasting

Unclassified

Order By: Relevance

“…Elevated rates of additional psychiatric comorbidity in patients with 2 versus 1 presenting disorder have been documented in a number of psychiatric populations (e.g., 20,21). Nevertheless, given that both obesity and anxiety comorbidity have been shown to correlate with indicators of poor prognosis in bipolar patients (e.g., delayed response to treatment, shorter time to recurrence) (22,23), future studies are needed to determine the impact of aberrant eating on the clinical course of bipolar disorder and its treatment. In addition, research to tease apart the temporal and pathophysiological relationships among eating disorder symptoms, obesity, mood disorder history, and other psychiatric co-morbidity seems warranted.…”

Section: Discussionmentioning

confidence: 99%

Eating disorders and illness burden in patients with bipolar spectrum disorders

Wildes

Marcus

Fagiolini

2007

Comprehensive Psychiatry

Self Cite

View full text Add to dashboard Cite

Objectives-To evaluate the clinical significance of lifetime eating disorder co-morbidity in a welldefined sample of patients with bipolar spectrum disorders and to describe cognitive correlates of disordered eating in this group.Method-Twenty-six bipolar patients with a lifetime history of a DSM-IV defined eating disorder (n = 17) or a clinically significant subthreshold eating disorder (n = 9) (ED group) were compared to 46 bipolar patients with no history of an eating disorder (No ED group) on demographic and clinical characteristics at study presentation, history of bipolar illness, and other psychiatric co-morbidity. Measures included the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), the Clinical Global Impression-Severity Scale-Bipolar Version (CGI-S-BP), and the Eating Disorder Examination (EDE). Height and weight were recorded to calculate body mass index (BMI).Results-Patients in the ED group were heavier and were rated as more symptomatic on the CGI-S-BP than were patients in the No ED group. The ED group also had a higher number of lifetime depressive episodes and greater psychiatric co-morbidity, excluding eating and mood disorders. Finally, after controlling for BMI and CGI-S-BP rating, patients in the ED group had significantly higher EDE Restraint, Eating Concern, Shape Concern, Weight Concern, and Global scores than did patients in the No ED group.Conclusions-These findings highlight the need for a renewed emphasis on the evaluation and management of weight and eating in the mood disorders. In particular, this research suggests that eating disorder co-morbidity may be a marker for increased symptom load and illness burden in bipolar disorder.

show abstract

Section: Discussionmentioning

confidence: 99%

Eating disorders and illness burden in patients with bipolar spectrum disorders

Wildes

Marcus

Fagiolini

2007

Comprehensive Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

“…18,19 Reports of the prevalence of suicidal ideation vary from 14% to 59% in bipolar samples [20][21][22][23][24][25] and only a few cross-sectional studies have examined variables that influence suicidal ideation in BD and its relationship with suicide attempts. Some risk factors associated with the presence of suicidal ideation are positive family history for affective disorder, severe depression, 12 psychotic symptoms, 26 past suicide attempt, 23,26 comorbidity with alcohol abuse or dependence, 23 panic spectrum symptoms, 27 and earlier age of onset. 28 Valtonen et al, in a cross-sectional study with a sample of 191 patients with bipolar disorder, showed that 61% (n = 116) reported suicidal ideation during the index-episode and 20% (n = 39) had attempted suicide in the same episode.…”

Section: Stress-diathesis Modelmentioning

confidence: 99%

Suicidal ideation and suicide attempts in bipolar disorder type I: an update for the clinician

Abreu

Lafer

Baca‐García

et al. 2009

Rev. Bras. Psiquiatr.

101

View full text Add to dashboard Cite

“…26,27 Comorbid psychiatric disorders (that is, dysthymia or obsessive-compulsive disorder (OCD)) could also reduce the overall response to treatment, or in some case could modify its timing. [28][29][30] Moreover, from a genetic perspective, the comorbidity with anxiety disorders, in particular the presence of panic-agoraphobic spectrum symptoms has been reported to be related with a different genetic background. 31 However, comorbidity is present to a large extent in depression, 32 and the exclusion of all comorbid patients will eventually again reduce representativeness.…”

Section: Clinical Features Of Depressionmentioning

confidence: 99%

Pharmacogenetic studies in depression: a proposal for methodologic guidelines

2007

View full text Add to dashboard Cite

Pharmacogenetic studies in mood disorders are rapidly proliferating after the initial reports linking gene variants to treatment outcomes. However, a considerable range of methodologies has been used, making it difficult to compare results across studies and limiting the representativeness of findings. Specification of sampling source (inpatients vs outpatients, primary vs tertiary settings), standardization of diagnostic systems and treatments, adequate monitoring of compliance through plasma levels, sufficient length of observation (at least 6 weeks for acute antidepressant treatments, though 3-6 months are preferable), the use of a range of response criteria and the inclusion of possible environmental confounding variables (life events, social support, temperament) are all potentially important issues when planning pharmacogenetic studies. We reviewed the state-of-the-art methodology and suggested possible guideline for future studies.

show abstract

Clinical Significance of Lifetime Panic Spectrum Symptoms in the Treatment of Patients With Bipolar I Disorder

Cited by 165 publications

References 35 publications

Eating disorders and illness burden in patients with bipolar spectrum disorders

Eating disorders and illness burden in patients with bipolar spectrum disorders

Suicidal ideation and suicide attempts in bipolar disorder type I: an update for the clinician

Pharmacogenetic studies in depression: a proposal for methodologic guidelines

Contact Info

Product

Resources

About