2012
DOI: 10.1016/j.oraloncology.2011.11.014
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Clinical significance of lymphatic and blood vessel invasion in oral tongue squamous cell carcinomas

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Cited by 63 publications
(60 citation statements)
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“…Elective neck dissection in the clinically negative neck has shown to improve survival [3], however neck dissection is not without complications [4]. In order to identify patients who are likely to have nodal metastases, several primary tumour factors like tumour differentiation, perineural invasion, lymphovascular invasion and tumour thickness have been studied [5][6][7]. Presently it is well recognized that tumour thickness or depth of invasion is an important predictor of nodal metastases in oral cancer [8].…”
Section: Introductionmentioning
confidence: 99%
“…Elective neck dissection in the clinically negative neck has shown to improve survival [3], however neck dissection is not without complications [4]. In order to identify patients who are likely to have nodal metastases, several primary tumour factors like tumour differentiation, perineural invasion, lymphovascular invasion and tumour thickness have been studied [5][6][7]. Presently it is well recognized that tumour thickness or depth of invasion is an important predictor of nodal metastases in oral cancer [8].…”
Section: Introductionmentioning
confidence: 99%
“…Several serum tumour markers have been evaluated with regard to clinical value in HNSCC and OSCC, but most of them demonstrated poor sensitivity [72,73] . This article focuses on the potential haematogenous spread of tumour cells while OSCC most often spreads in lymphatic vessels [74][75][76] , potentially decreasing the relevance regarding OSCC/HNSCC. However, there are increasing signs that CTCs are clinically relevant in the pathogenesis and recurrence of head and neck tumours.…”
Section: A Discussion Of the Results From Studies On Head And Neck Camentioning
confidence: 99%
“…Monoclonal anti-podoplanin, clone D2-40, is a reliable lymphatic endothelial cell marker which identifies podoplanin in lymphatic endothelium [24,25,45]. In many cancers, the role of podoplanin has associated with tumor progression and metastasis [46].…”
Section: Discussionmentioning
confidence: 99%
“…D2-40 was originally recognized as an oncofetal antigen, M2A antigen, which is an O-linked sialoglycoprotein with a simple mucintype carbohydrate epitope associated with germ-cell neoplasms [24,25]. Currently, it is known that podoplanin and M2A antigen are identical proteins [25].…”
Section: Introductionmentioning
confidence: 99%