Clinical significance of lymphatic invasion in the esophageal region in patients with adenocarcinoma of the esophagogastric junction

Sugita, Shizuki; Kuwata, Takeshi; Tokunaga, Masanori; Kaito, Akio; Watanabe, Masahiro; Tonouchi, Akiko; Kinoshita, Takahiro; Nagino, Masato

doi:10.1002/jso.25964

Cited by 7 publications

(8 citation statements)

References 25 publications

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“…lww.com/SLA/ D666). [4][5][6][7][8] Of note, in 3 studies that reported the treatment landscape in patients with metastatic PDAC in the Netherlands, the percentage of patients with anticancer treatment ranged from 18% to 29%, and the median overall survival times were in the range of 2 months. 5,7,8 These poor survival data are in line with a large SEER database analysis, that reported a median overall survival for metastatic PDAC diagnosed in the US between 1993 and 2013 of 2 months.…”

Section: Comment On: "A Randomized Controlled Trial Evaluating Electr...mentioning

confidence: 99%

“…[4][5][6][7][8] Of note, in 3 studies that reported the treatment landscape in patients with metastatic PDAC in the Netherlands, the percentage of patients with anticancer treatment ranged from 18% to 29%, and the median overall survival times were in the range of 2 months. 5,7,8 These poor survival data are in line with a large SEER database analysis, that reported a median overall survival for metastatic PDAC diagnosed in the US between 1993 and 2013 of 2 months. 6 As an explanation for not using established and approved medical treatment options for PDAC with (metachronous or synchronous) metastases authors mostly name poor performance status and wish of the patient.…”

Section: Comment On: "A Randomized Controlled Trial Evaluating Electr...mentioning

confidence: 99%

“…This is different from previous perceptions that data collection is usually considered to be well supported by research personnel and infrastructure in patientreported outcome (PRO) clinical trials. 8 Given that this study included more than 2600 patients, following up each patient's UCC visits was a daunting task. However, all patients who participated in this study completed an electronic questionnaire and were highly compliant.…”

Section: Comment On: "A Randomized Controlled Trial Evaluating Electr...mentioning

confidence: 99%

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“…9 Several previous studies described clinical indicators to predict MLNMs in patients with EGJC. [10][11][12] In addition, it has been a controversial issue whether MLN dissection has survival bene ts. [5][6][7][8] The present study was conducted to identify the factors associated with mediastinal lymph node positivity in patients with proximal gastric tumors who received curative surgical treatment.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with mediastinal lymph node positivity in proximal gastric tumor patients undergoing curative surgery

Parsak

Topal

Altiok

et al. 2022

Preprint

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Purpose: This study investigated the risk factors associated with mediastinal lymph node metastases due to proximal gastric cancer. Methods: The study included patients who had surgical resection and Transcrural lymphadenectomy for proximal gastric tumors between January 2012 and January 2020. The patients were divided into Group1 (negative) and Group2 (positive) according to the positivity of mediastinal lymph nodes. These groups were compared for clinical variables. The diagnostic value of composite immunonutritional and inflammatory indices in predicting lymph node positivity was examined. Results: There were 88 patients in our study. Group1 included 54 and Group2 included 34 patients.Among the laboratory parameters, only CRP was higher in Group 2 (4.58 vs. 10.7, p= 0.044). The rate of postoperative respiratory complications (5.6% vs. 29.4%, p:0.002) was higher in Group2 The tumor size (25.3 vs. 33 mm, p:0.0001), was higher in Group2. Tumors were more advanced in Group2 (p<0.001). Among the composite indices, only the neutrophil-to-lymphocyte ratio had a diagnostic value, with a sensitivity of 67.65% and a specificity of 55.56% at a cut-off point of >2.19. According to the multivariate analysis, a tumor size of >3 cm, a CRP value of >7, and tumor localization were independent risk factors. Conlusion: Our study found that mediastinal lymph node positivity was associated with elevated CRP and that these patients had more advanced tumors and poor histopathological characteristics. Knowing the relationship between clinicopathological characteristics and mediastinal lymph node positivity in proximal gastric tumors can be useful in determining the surgical strategy for EGJ tumors.

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Section: Introductionmentioning

confidence: 99%

“Factors associated with mediastinal lymph node positivity in proximal gastric tumor patients undergoing curative surgery”

Parsak

Topal

Altiok

et al. 2022

Preprint

View full text Add to dashboard Cite

Purpose: This study investigated the risk factors associated with mediastinal lymph node metastases due to proximal gastric cancer. Methods The study included patients who had surgical resection and Transcrural lymphadenectomy for proximal gastric tumors between January 2012 and January 2020. The patients were divided into Group1 (negative) and Group2 (positive) according to the positivity of mediastinal lymph nodes. These groups were compared for clinical variables. The diagnostic value of composite immunonutritional and inflammatory indices in predicting lymph node positivity was examined. Results There were 88 patients in our study. Group1 included 54 and Group2 included 34 patients.Among the laboratory parameters, only CRP was higher in Group 2 (4.58 vs. 10.7, p= 0.044). The rate of postoperative respiratory complications (5.6% vs. 29.4%, p:0.002) was higher in Group2 The tumor size (25.3 vs. 33 mm, p:0.0001), was higher in Group2. Tumors were more advanced in Group2 (p<0.001). Among the composite indices, only the neutrophil-to-lymphocyte ratio had a diagnostic value, with a sensitivity of 67.65% and a specificity of 55.56% at a cut-off point of >2.19. According to the multivariate analysis, a tumor size of >3 cm, a CRP value of >7, and tumor localization were independent risk factors. Conlusion Our study found that mediastinal lymph node positivity was associated with elevated CRP and that these patients had more advanced tumors and poor histopathological characteristics. Knowing the relationship between clinicopathological characteristics and mediastinal lymph node positivity in proximal gastric tumors can be useful in determining the surgical strategy for EGJ tumors.

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Clinical significance of lymphatic invasion in the esophageal region in patients with adenocarcinoma of the esophagogastric junction

Cited by 7 publications

References 25 publications

Comment on: “A Randomized Controlled Trial Evaluating Electronic Outpatient Symptom Monitoring After Ambulatory Cancer Surgery”

Comment on: “A Randomized Controlled Trial Evaluating Electronic Outpatient Symptom Monitoring After Ambulatory Cancer Surgery”

Factors associated with mediastinal lymph node positivity in proximal gastric tumor patients undergoing curative surgery

“Factors associated with mediastinal lymph node positivity in proximal gastric tumor patients undergoing curative surgery”

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