Clinical significance of macroscopic completeness of mesorectal resection in rectal cancer

Leite, Júlio Soares; Martins, Sheila Cristina Ouriques; Oliveira, J.; Cunha, Miguel F.; Castro-Sousa, Francisco

doi:10.1111/j.1463-1318.2009.02153.x

Cited by 44 publications

(41 citation statements)

References 16 publications

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“…The results of Maslekar et al confirmed that grade of mesorectun independently influenced both local and overall recurrences [21]. Meanwhile, Leite et al revealed that the mesorectal score was an independent factor for local recurrence and disease-free survival [22]. Furthermore, Lino-Silva et al used a two-grade system to determine the prognostic value of the mesorectum quality, and results suggested that inadequate mesorectum was correlated with R1/R2 resections, positive margins, and decrease survival, so the two-grade system (adequate, inadequate) was proposed [23].…”

Section: Discussionmentioning

confidence: 99%

GOLPH3 overexpression correlates with poor response to neoadjuvant therapy and prognosis in locally advanced rectal cancer

et al. 2016

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Neoadjuvant chemoradiotherapy (nCRT) combined with surgery is a standard therapy for locally advanced rectal cancer (LARC). The aim of this study was to assess the expression of GOLPH3 (Golgi phosphoprotein 3), a newly found oncogene, in LARC as well as its relationship with nCRT sensitivity and prognosis. We retrospectively analyzed 148 LARC cases receiving nCRT and total mesorectal excision (TME). Immunohistochemistry was used to assess GOLPH3 and mTOR (mammalian target of rapamycin) in tumor tissues. Then, the associations of GOLPH3 with pathological characteristics and prognosis of rectal cancer were assessed. The 148 cases included 77 with high GOLPH3 expression (52.03%), which was associated with tumor invasive depth and lymphatic metastasis. Cases with high GOLPH3 expression had 2.58 and 2.71 fold higher local relapse and distant metastasis rates compared with the low expression group. Correlation analyses showed that GOLPH3 was an independent indicator for judging tumor down-staging and postoperative TRG (tumor regression grade), indicating it could predict nCRT sensitivity. In addition, GOLPH3 expression was associated with mTOR levels. Multiple-factor analysis indicated that GOLPH3 was an independent prognosis indicator for 5 year-DFS (disease free survival) and OS (overall survival) in LARC. These results reveal that GOLPH3 is an independent predictive factor for nCRT sensitivity and prognosis in LARC, with a mechanism related to mTOR.

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Section: Discussionmentioning

confidence: 99%

GOLPH3 overexpression correlates with poor response to neoadjuvant therapy and prognosis in locally advanced rectal cancer

et al. 2016

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“…In our study on low rectal cancer we reported the surgical quality of APR specimens only, and this may explain the high percentage of muscularis propria resection planes [14]. The results reported by Leite et al (2009) [18] may be explained as a reflection of the individual performance of a single center, whereas Leonard et al (2010) [20•] describe an audit of the performance of 33 potential expert surgeons from multiple centers in Belgium. Surgeons in the latter study are candidate-TME-trainers, who agreed to an external audit of their consecutive TME cases to judge whether they could serve as an alternative to foreign TME experts in a national teaching program.…”

Section: Incidencementioning

confidence: 96%

The Importance of the Pathologist’s Role in Assessment of the Quality of the Mesorectum

Bosch

Nagtegaal

2012

Curr Colorectal Cancer Rep

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Total mesorectal excision (TME) is considered standard of care for rectal cancer treatment. Failure to remove the mesorectal fat envelope entirely may explain part of observed local and distant recurrences. Several studies suggest quality of the mesorectum after TME surgery as determined by pathological evaluation may influence prognosis. We aimed to determine the prognostic value of the plane of surgery as well as factors influencing the likelihood of a high-quality specimen by reviewing the literature. A pooled meta-analysis of relevant outcome data was performed where appropriate. A muscularis propria resection plane was found to increase the risk of local recurrence (RR 2.72 [95 % CI 1.36 to 5.44]) and overall recurrence (RR 2.00 [95 % CI 1.17 to 3.42]) compared to an (intra)mesorectal plane. Plane of surgery is an important factor in rectal cancer treatment and the documentation by pathologists is essential for the improvement of TME quality and patient outcome.

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“…Bei intaktem Mesorektum betrug das 5-Jahres-tumorfreieÜberleben 65 % im Vergleich zu 47 % bei Defekten des Mesorektums (P< 0,05) [831]. Nach 3 Jahren Follow-up betrug die Lokalrezidivrate bei intakter mesorektaler Faszie 4 % (3 -6 %), 7 % (5 -11 %) bei intramesorektalen Einrissen, und 13 % (8 -21 %) bei Erreichen der Muscularis-propria-Ebene [827].…”

Section: Multiviszerale Resektionunclassified

S3-Leitlinie – Kolorektales Karzinom

Schmiegel

Buchberger

Follmann³

et al. 2017

Z Gastroenterol

151

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Clinical significance of macroscopic completeness of mesorectal resection in rectal cancer

Abstract: The outcome of surgical treatment of rectal cancer is related to the completeness of mesorectal excision. It is a more discriminative prognostic factor than the classic tumour-node-metastasis (TNM) system.

Cited by 44 publications

References 16 publications

GOLPH3 overexpression correlates with poor response to neoadjuvant therapy and prognosis in locally advanced rectal cancer

GOLPH3 overexpression correlates with poor response to neoadjuvant therapy and prognosis in locally advanced rectal cancer

The Importance of the Pathologist’s Role in Assessment of the Quality of the Mesorectum

S3-Leitlinie – Kolorektales Karzinom

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