Clinical significance of Matrilin-3 gene polymorphism in Egyptian patients with primary knee osteoarthritis

Diab, Safia M; Kamal, Howyda M.; Mansour, Amira I.; Fawzy, Rasha M.; Azab, Basma S

doi:10.5152/eurjrheum.2016.16107

Cited by 13 publications

(9 citation statements)

References 24 publications

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“…[14] The study used 10 as the threshold, which was reported in a previous article. [2] Smokers was defined as individuals who had smoked at least 1 cigarette per day for at least 2 years. Individuals were defined as alcohol consumers if they drank alcohol at least once a week for more than 1 year.…”

Section: Methodsmentioning

confidence: 99%

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Association between interleukin-17A/F single nucleotide polymorphisms and susceptibility to osteoarthritis in a Chinese population

et al. 2019

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Interleukin-17A/F (IL-17A/F) might play a role in the pathophysiology of osteoarthritis (OA), but several studies exploring the association between IL-17A/F single nucleotide polymorphisms and OA in different populations present inconsistent results. Thus, this case–control study, involving 410 OA cases and 507 controls, was aimed to investigate such association in a Chinese population. Genotyping was performed using standard polymerase chain reaction and restriction fragment length polymorphism. It was found that AA genotype or A allele carriers of IL-17A gene rs2275913 polymorphism were associated with OA susceptibility. Stratified analyses showed IL-17A rs2275913 polymorphism was evidently associated with a significantly increased risk for OA among males, <60 years old patients, smokers, and drinkers. No significant association was observed between IL-17F gene rs763780 polymorphism and OA risk. In conclusion, IL-17A rs2275913 polymorphism is involved in the development of OA in Chinese Han population. This finding should be confirmed by a larger study from diverse ethnic populations.

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Section: Methodsmentioning

confidence: 99%

“…[1] OA is responsible for activity limitations, particularly walking, and affects participation and quality of life. [2] However, the etiology of OA is not fully understood. There is an evidence that genetic risk factors play important roles in the development of OA.…”

Section: Introductionmentioning

confidence: 99%

Association between interleukin-17A/F single nucleotide polymorphisms and susceptibility to osteoarthritis in a Chinese population

et al. 2019

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“…The Egyptian study revealed more severe knee OA patients with the B\b genotype, while patients with the b\b genotype showed less severe disability and radiological severity than those with the B\b genotype. 23 Patients with the B\B genotype had the least disability, and their radiological findings were the mildest. This means that patients with the B\b genotype had worse clinical and radiological findings than other those with the B\B and b\b genotypes.…”

Section: Resultsmentioning

confidence: 98%

“…The Egyptian and Indian case-control study included 50 primary knee OA patients (Group I) fulfilling the American College of Rheumatology (ACR) classification criteria of knee OA 22 who attended Benha University hospital and ELMC Lucknow hospital Uttar Pradesh, India respectively, together with 50 age and sex-matched apparently healthy controls (Group II) with no symptoms or signs on clinical examination or radiographic changes indicative of knee OA or other joint disease. 20,23 Our interesting observation was that Indian study seems to draw its inspiration from Egyptian therefore patient cohort, methodology, criterion for inclusion /exclusion seem to mirror each other. Both studies excluded the patient having isolated patello-femoral OA; secondary OA due to trauma or deformity; metabolic disorders such as diabetes mellitus, thyroid disorders, or Cushing syndrome; or renal failure or were undergoing dialysis; infectious disorders such as septic arthritis, viral arthritis, or fungal arthritis; ,inflammatory arthritis such as rheumatoid arthritis, systematic lupus erythematosus, and sero-negative arthritis; malignancy; bilateral knee replacements; or relatives included in the study.…”

Section: Study Subjectsmentioning

confidence: 97%

Matrilin-3 gene polymorphism in primary knee osteoarthritis: An Evidence based systematic review

Sharma

Singh²,

Singh

et al. 2020

Asian J Med Sci

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There have been few studies in English literature identifying the potential association and clinical significance of MATN-3 rs8176070 (SNP6) polymorphism in patients with primary knee Osteoarthritis Knee. Objective of this paper was to evaluate the association of matrilin gene-3 and primary osteoarthritis of knee through systematic review of these studies. We did an extensive literature using relevant keywords .3 eligible studies were included for systematic review. Two studies showed significant association, in which Patients with the B\b genotype had worse clinical and radiological findings than those with B\B and b\b genotype. The third study in Indian population did not find any correlation. On the basis of this systematic review we can safely suggest that there is dearth of such studies in literature therefore more of such studies with wider and larger study population shall be undertaken to find Correlation of genetic in this multifactorial disorder and possible cure.

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“…Many previous studies have reported an association between osteoporosis and genetic variants using genome-wide association studies and candidate gene association studies. Especially, there are many reports of SNPs associated with genes predicted to be involved in osteoporosis prevalence [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. However, most genetic variants are related to inflammation [ 25 , 26 , 27 , 28 ], extracellular matrix mechanisms [ 29 , 30 ], and vitamin D metabolism [ 31 , 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

3′-UTR Polymorphisms of MTHFR and TS Associated with Osteoporotic Vertebral Compression Fracture Susceptibility in Postmenopausal Women

Ahn

Kim

et al. 2018

IJMS

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Postmenopausal osteoporosis is one of the most prominent diseases in postmenopausal women and it is increasing in prevalence with the aging population. Furthermore, osteoporosis and osteoporotic vertebral compression fractures (OVCFs) are related to mortality and decreased quality of life. Therefore, searching for biomarkers that are able to identify postmenopausal women who are at high risk of developing OVCFs is an effective strategy for improving the quality of life of patients and alleviating social and economic burdens. In this study, we investigated methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) gene polymorphisms in postmenopausal women with OVCF. We recruited 301 postmenopausal women and performed genotyping for the presence of MTHFR 2572C>A, 4869C>G and TS 1100C>T, 1170A>G. Genotyping was analyzed using the polymerization chain reaction restriction fragment length polymorphism assay. MTHFR 2572C>A and TS 1100C>T were associated with the prevalence of osteoporosis (MTHFR 2572CC versus CA+AA: odd ratio [OR] adjusted age, hypertention [HTN], and diabetes mellitus [DM] = 0.49, p = 0.012) and the occurrence of OVCFs (MTHFR 2572CC versus CA+AA: OR adjusted age, HTN, and DM = 0.38, p = 0.013; TS 1100CC versus CT+TT: OR adjusted age, HTN, and DM = 0.46, p = 0.02). Our novel finding is the identification of MTHFR and TS genetic variants that decrease susceptibility to OVCFs. Our findings suggest that polymorphisms in the MTHFR and TS genes are associated with susceptibility to osteoporosis and OVCFs in postmenopausal women.

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Clinical significance of Matrilin-3 gene polymorphism in Egyptian patients with primary knee osteoarthritis

Cited by 13 publications

References 24 publications

Association between interleukin-17A/F single nucleotide polymorphisms and susceptibility to osteoarthritis in a Chinese population

Association between interleukin-17A/F single nucleotide polymorphisms and susceptibility to osteoarthritis in a Chinese population

Matrilin-3 gene polymorphism in primary knee osteoarthritis: An Evidence based systematic review

3′-UTR Polymorphisms of MTHFR and TS Associated with Osteoporotic Vertebral Compression Fracture Susceptibility in Postmenopausal Women

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