Clinical significance of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio and prognostic nutritional index in low-risk differentiated thyroid carcinoma

Offi, Chiara; Romano, Roberto Maria; Cangiano, Angelo; Candela, Giancarlo; Docimo, Giovanni

doi:10.14639/0392-100x-n1089

Cited by 18 publications

(19 citation statements)

References 26 publications

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“…One study found that low PNI was associated with decreased RFS in univariate analysis; however, the multivariate analysis indicated no significant association between PNI and RFS (54). Regarding low-risk differentiated thyroid carcinoma, one study found there to be no significant association between PNI and RFS, either in univariate or multivariate analysis (55). In a multicenter retrospective study with 1,873 papillary thyroid carcinoma patients, low PNI was shown to be an independent risk factor for low RFS in multivariate analysis (56).…”

Section: Thyroid Cancermentioning

confidence: 99%

“…Two retrospective studies with a small sample size investigated the prognostic value of PNI in medullary thyroid carcinoma (54) and low-risk differentiated thyroid carcinoma (55). One study found that low PNI was associated with decreased RFS in univariate analysis; however, the multivariate analysis indicated no significant association between PNI and RFS (54).…”

Section: Thyroid Cancermentioning

confidence: 99%

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Long-term and short-term prognostic value of the prognostic nutritional index in cancer: a narrative review

Li¹,

Nakamura²,

Casadei-Gardini³

et al. 2021

Ann Transl Med

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Objective: To perform a narrative review of the prognostic value of prognostic nutritional index (PNI) in cancers.Background: Prognostic estimation greatly determines the treatment approach in various cancers. The prognostic nutritional index (PNI), calculated using the serum albumin level and total lymphocyte count, is a useful indicator to assess nutritional and immunological conditions. The PNI represents a low-cost, easy-toperform, noninvasive, rapid, and standardized tool for estimating the prognosis of cancer. Many studies have aimed to clarify the prognostic value of PNI for various types of cancer. Methods:We summarize the studies, particularly the systematic reviews and meta-analyses, that have examined the prognostic value of PNI in common cancers. Conclusions:The relevant studies indicate that low PNI is an independent prognostic factor for decreasing overall survival in many types of cancers. Disease-free survival and progression-free survival were also associated with PNI in some types of cancer including lung cancer and renal cell carcinoma. Therefore, we suggest that the measurement of PNI is a useful method to identify cancer patients that have a worse prognosis and that the treatment strategy for these patients be adjusted accordingly. We hypothesize that maintaining good nutritional status during treatment may improve outcomes of various cancers.

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Section: Thyroid Cancermentioning

confidence: 99%

Section: Thyroid Cancermentioning

confidence: 99%

Long-term and short-term prognostic value of the prognostic nutritional index in cancer: a narrative review

Li¹,

Nakamura²,

Casadei-Gardini³

et al. 2021

Ann Transl Med

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“…Seretis et al were the first to show that NLR may predict the presence of PTC [11]. Subsequent studies showed higher NLR in PTC patients [22,32] and association with tumor size [14,33], extrathyroidal extension [33], lymph node metastases [34] or cancer recurrence [13]. Furthermore, a recent meta-analysis published by Feng et al…”

Section: Discussionmentioning

confidence: 99%

“…Gong et al also reported that the preoperative NLR was closely related to the stage of papillary thyroid carcinoma [12]. NLR was also shown to be a prognostic factor for recurrence in low-risk DTC patients [13], and a correlation between NLR and tumor size in thyroid cancers has been shown by Cheong et al [14]. Additionally, recent studies suggest that platelet indices may be possible markers in the differential diagnosis of benign and malignant thyroid disorders.…”

Section: Introductionmentioning

confidence: 93%

Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer

et al. 2021

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Background: The primary endpoint was to analyze the preoperatory inflammatory markers and platelet indices in papillary thyroid cancer (PTC) patients compared with patients with benign thyroid pathology. The secondary endpoints were to analyze the relationship between these markers and the pathological features of PTC and to compare their pre- and postoperative levels in PTC patients. Methods: In this retrospective case-control study, we analyzed the files of 1183 patients submitted to thyroidectomy between January 2012 and December 2018. A total of 234 patients with PTC (mean age 51.54 ± 13.10 years, 84.6% females) were compared with an age-, gender- and BMI-matched control group of 108 patients with histologic benign thyroid disorders. Results: PTC patients had higher platelet count (PLT) (p = 0.011), plateletcrit (PCT) (p = 0.006), neutrophil (p = 0.022) and fibrinogen (p = 0.005) levels. Subgroup analysis showed that PTC females had higher PLT (p = 0.006), PCT (p < 0.001) and erythrocyte sedimentation rate (ESR) (p = 0.005), while males had higher neutrophil (p = 0.040) levels. Papillary thyroid cancer patients under 55 years had higher PLT (p < 0.001) and PCT (p = 0.010), while patients over 55 years had higher mean platelet volume (p = 0.032), neutrophil-to-lymphocyte ratio (p = 0.013), ESR (p = 0.005) and fibrinogen (p = 0.019) levels. Preoperative values for platelet indices and inflammatory markers were similar to the postoperative determinations in PTC patients. Fibrinogen (AUROC = 0.602, p = 0.02; cut-off = 327.5 mg/dL, Se = 53.8%, Sp = 62.9%) and PLT (AUROC = 0.584, p = 0.012; cut-off = 223.5 × 103/mm3, Se = 73.1%, Sp = 42.6%) were independent predictors of the presence of PTC. Conclusions: Our data show that fibrinogen and platelet count could be promising, inexpensive, independent predictors for the presence of PTC when compared with benign thyroid disorders.

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“…Several studies have proved the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), mean platelet volume-to-platelet ratio (MPV/PLT), and systemic immune-inflammation index (SII) as novel biomarkers of chronic subclinical inflammation in the thyroid, adrenal gland, and neuroendocrine tumors [14,[17][18][19][20]. Moreover, these ratios have been proposed as potential indicators to differentiate malignant from benign neoplasms in the preoperative period, and predict the prognosis and response to treatment [21][22][23][24][25][26][27]. Some authors proved that preoperative NLR and PLR values may provide effective guidance about long-term outcomes, including the recurrence rate and progression-free survival in craniopharyngiomas and meningiomas [28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte Ratios, and Systemic Immune-Inflammation Index as Potential Biomarkers of Chronic Inflammation in Patients with Newly Diagnosed Acromegaly: A Single-Centre Study

Szydełko

Szydełko-Gorzkowicz

Matyjaszek‐Matuszek

2021

JCM

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Acromegaly is a rare disease caused by overproduction of growth hormone (GH) by a pituitary adenoma, and consequently increased insulin-like growth factor 1 (IGF-1) concentration. The GH/IGF-1 axis and immune cells interactions are hypothesized to be involved in subclinical inflammation. This retrospective study aimed to investigate the differences in neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR) ratios, and systemic immune-inflammation index (SII) in GH-secreting adenomas compared with non-functioning pituitary adenomas (NFPAs) concerning clinical and radiological findings. After evaluation of 665 patients with pituitary tumors, 62 individuals with newly diagnosed acromegaly and 134 with NFPAs were enrolled in the analysis. The control group consisted of 120 healthy individuals. Fifty-eight patients with acromegaly were re-evaluated after medical or surgical therapies. NLR, PLR, SII values, and neutrophil count were significantly higher (p ≤ 0.001), whereas lymphocyte count was lower in acromegaly than in NFPAs (p = 0.001). No significant differences between NFPAs and controls were observed in analyzed ratios. Higher preoperative NLR, PLR, SII values were found in patients who failed to achieve a cure with surgery (p < 0.05). Although NLR, PLR, and SII values were significantly higher in acromegaly, these indices cannot be used to discriminate GH-secreting pituitary tumors from NFPAs. Treatment of acromegaly decreased the value of NLR and SII, but it requires further studies to consolidate the real clinical role of these inflammation-related ratios.

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Clinical significance of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio and prognostic nutritional index in low-risk differentiated thyroid carcinoma

Cited by 18 publications

References 26 publications

Long-term and short-term prognostic value of the prognostic nutritional index in cancer: a narrative review

Long-term and short-term prognostic value of the prognostic nutritional index in cancer: a narrative review

Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer

Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte Ratios, and Systemic Immune-Inflammation Index as Potential Biomarkers of Chronic Inflammation in Patients with Newly Diagnosed Acromegaly: A Single-Centre Study

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