Clinical significance of osseous spurs on the dorsoproximal aspect of the third metatarsal bone

Fairburn, A. J.; Dyson, Sue; Murray, Rachel C.

doi:10.1111/j.2042-3306.2010.00097.x

Cited by 21 publications

(26 citation statements)

References 19 publications

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“…Left‐right asymmetry of radiopharmaceutical uptake in the distal hock region of normal horses and a possible influence of discipline on the pattern of radiopharmaceutical uptake has been identified . Radiological changes consistent with osteoarthritis of the centrodistal and or tarsometatarsal joints can sometimes be seen as incidental findings in lame horses . In this study there was a moderate prevalence of increased radiopharmaceutical uptake in the distal hock region (30.3%) of horses with a negative final diagnosis.…”

Section: Discussionmentioning

confidence: 53%

“…37 Radiological changes consistent with osteoarthritis of the centrodistal and or tarsometatarsal joints can sometimes be seen as incidental findings in lame horses. 52,53 In this study there was a moderate prevalence of increased radiopharmaceu- horses. 50,54,55 Diagnostic analgesia can confirm the presence of pain in the sacroiliac joint region.…”

Section: Hocks and Sacroiliac Jointsmentioning

confidence: 58%

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Evaluation of the diagnostic accuracy of skeletal scintigraphy in lame and poorly performing sports horses

Quiney

Ireland

Dyson

2018

Vet Radiology Ultrasound

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Skeletal scintigraphy is an established imaging modality, however, its validity as a diagnostic test in lame or poorly performing sports horses has not been determined. The objective of this retrospective cross-sectional analytical study was to determine the accuracy of skeletal scintigraphy as an indiscriminate screening test in sports horses. All sports horses that underwent scintigraphic examination between March 2008 and December 2014 for which a definitive diagnosis was reached were included. Examinations were evaluated blindly. Characteristics of increased radiopharmaceutical uptake were recorded and subjectively categorized as possibly relevant or non-relevant. Kappa statistics were used to assess agreement between test results and final diagnosis. There were 1222 positive clinical diagnoses in 480 horses, of which 687 regions (56.4%) had no associated increased radiopharmaceutical uptake and 99 regions (8.1%) had non-relevant increased radiopharmaceutical uptake. The sensitivity of increased radiopharmaceutical uptake for identification of final diagnosis was low (43.8%) and specificity was high (94.0%). The agreement was fair (κ = 0.36). Relevance categorization improved the test; the sensitivity for final diagnosis was low (35.7%), specificity was high (98.9%), and the agreement was moderate (κ = 0.45). The agreements of increased radiopharmaceutical uptake and relevance categorization with final diagnosis were only substantial for feet (κ = 0.67 and κ = 0.66, respectively) and proximal aspect of the forelimb (elbow, shoulder, and scapula combined) (κ = 0.69 and 0.78, respectively). Scintigraphic examination is unlikely to lead to a full and correct diagnosis of the cause(s) of lameness or poor performance in sports horses when used as an isolated or indiscriminate screening tool.

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Section: Discussionmentioning

confidence: 53%

Section: Hocks and Sacroiliac Jointsmentioning

confidence: 58%

Evaluation of the diagnostic accuracy of skeletal scintigraphy in lame and poorly performing sports horses

Quiney

Ireland

Dyson

2018

Vet Radiology Ultrasound

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“…There is substantial overlap in diagnostic imaging findings in horses that are symptomatic and those that are asymptomatic for thoracolumbar pain . Poor correlations between diagnostic imaging abnormalities and clinical disease or lameness have been documented in other musculoskeletal diseases in the horse, such as the small tarsal joints and osseous spurs on the dorsoproximal aspect of the third tarsal bone . Studies have also reported that many radiographic lesions, such as on repository radiographs in western performance horses, are not associated with performance …”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10] Poor correlations between diagnostic imaging abnormalities and clinical disease or lameness have been documented in other musculoskeletal diseases in the horse, such as the small tarsal joints and osseous spurs on the dorsoproximal aspect of the third tarsal bone. 26,27 Studies have also reported that many radiographic lesions, such as on repository radiographs in western performance horses, are not associated with performance. 28 Other clinical findings, such as pain on palpation of the dorsum, can also be misleading.…”

Section: Discussionmentioning

confidence: 99%

Long‐term outcome and effect of diagnostic analgesia in horses undergoing interspinous ligament desmotomy for overriding dorsal spinous processes

et al. 2020

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Objective To report the long‐term outcome of horses treated with interspinous ligament desmotomy (ISLD) for pain associated with overriding dorsal spinous processes (ORDSP) and determine the influence of preoperative diagnostic analgesia on long‐term outcome. Study design Retrospective study. Animals Eighteen horses. Methods Data were collected from horses presenting for ISLD to the University of Pennsylvania New Bolton Center between January 2013 and May 2018. Follow‐up of ≥3 months postsurgically was obtained from the owner, trainer, or referring veterinarian. Long‐term improvement was compared between horses that improved with diagnostic analgesia presurgically and horses that did not undergo diagnostic analgesia presurgically by using a χ2 test. Univariate logistic regression was used to test associations between long‐term improvement and independent variables. Results Clinical signs had improved in 13 of 18 horses at long‐term follow‐up (median, 14.5 months; range, 3‐57). Clinical signs improved in nine of 10 horses responding to diagnostic analgesia but only in four of eight horses that did not undergo diagnostic analgesia (χ2[1], N = 18) = 3.55; P = .06). Although the likelihood of long‐term improvement increased with prior diagnostic analgesia (odds ratio = 6.3; 95% confidence interval = 0.73, 55.0; P = .09), it did not reach statistical significance. Conclusion A higher proportion of horses experienced long‐term improvement in clinical signs after ISLD when horses responding to preoperative diagnostic analgesia were compared with horses that were not tested. Clinical significance This study provides some evidence to support the use of diagnostic analgesia in conjunction with clinical examination for identification of clinically relevant ORDSP.

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“…Spontaneous radiographic OA in the distal tarsus has been reported in 30–60% of horses and is more prevalent in older horses . While radiographic changes in the tarsus have variable correlation with lameness , once there is clinical suspicion of distal tarsal OA, radiographs are frequently used to identify structural changes such as joint space narrowing, lysis and sclerosis of subchondral bone (SCB), mineralisation front defects and osteophyte/enthesophyte development which may help determine prognosis .…”

Section: Introductionmentioning

confidence: 99%

The association between collagen and bone biomarkers and radiographic osteoarthritis in the distal tarsal joints of horses

Coppelman

David

Tóth

et al. 2019

Equine Veterinary Journal

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Summary Background Osteoarthritis (OA) of the distal intertarsal (DIT) and tarsometatarsal (TMT) joints occurs commonly. Synovial fluid (SF) biomarkers of collagen and bone turnover have potential clinical value. Objectives To measure SF biomarker concentrations from DIT and TMT joints in adult horses and determine if they correlate with radiographic OA severity and are higher in joints with radiographic OA compared to controls. Study design Cross‐sectional. Methods Radiographic OA of DIT and TMT joints was evaluated from adult horses (5–35 years old). Overall radiographic scores divided horses into those with mild or moderate radiographic OA (16 joints from 9 horses) or controls (13 joints from 9 horses). Direct biomarkers of OA (Carboxypropeptide of type II collagen = CPII, carboxy‐neoepitope of type II collagen exposed after collagenase‐cleavage = C2C, Bone alkaline phosphatase = BAP and Chondroitin sulfate epitope = CS846) were measured via ELISA and CPII/C2C was calculated. Biomarkers were correlated with radiographic findings and concentrations from those with radiographic OA to control joints and were compared. Results Concentrations of CPII (R = 0.84, P<0.001), C2C (R = 0.69, P<0.001) and BAP (R = 0.41, P = 0.03) as well as CPII/C2C (R = 0.69, P<0.001) values positively correlated with overall radiographic scores. Adjusted means ± s.d., after controlling for age, for CPII (P<0.001), C2C (P<0.001), CPII/C2C (P = 0.004) and BAP (P = 0.05) were significantly higher in DIT and TMT joints with radiographic OA (CPII: 2174.45 ± 1064.01; C2C: 233.52 ± 51.187; CPII/C2C: 9.01 ± 4.09; BAP: 21.98 ± 15.34) compared to controls (CPII: 594.53 ± 463.05; C2C: 153.12 ± 48.95; CPII/C2C: 3.96 ± 2.38; BAP: 12.76 ± 3.61). CPII (P<0.001), C2C (P = 0.001) and CPII/C2C (P = 0.001) were significantly higher with moderate radiographic OA (CPII: 2444.61 ± 772.78; C2C: 248.90 ± 44.94; CPII/C2C: 9.47 ± 2.97) compared to controls (CPII: 658.38 ± 417.36; C2C: 156.49 ± 47.61; CPII/C2C: 4.15 ± 2.04), with CPII also showing significantly higher concentrations (P = 0.04) with mild radiographic OA compared (1515.00 ± 584.95) to controls (658.38 ± 417.36). There were no differences in CS846 concentrations between radiographic OA and control joints. Age positively correlated with CPII (R = 0.48, P = 0.01) and C2C (R = 0.44, P = 0.02) concentrations. Main limitations Radiographic OA was assessed, not clinical lameness. Controls were not age‐matched to those with spontaneous radiographic OA. Conclusions There is an association between collagen (CPII, C2C and CPII/C2C) and bone (BAP) biomarkers and radiographic OA in the distal tarsal joints of horses.

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Clinical significance of osseous spurs on the dorsoproximal aspect of the third metatarsal bone

Cited by 21 publications

References 19 publications

Evaluation of the diagnostic accuracy of skeletal scintigraphy in lame and poorly performing sports horses

Evaluation of the diagnostic accuracy of skeletal scintigraphy in lame and poorly performing sports horses

Long‐term outcome and effect of diagnostic analgesia in horses undergoing interspinous ligament desmotomy for overriding dorsal spinous processes

The association between collagen and bone biomarkers and radiographic osteoarthritis in the distal tarsal joints of horses

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