Clinical significance of p53 functional loss in squamous cell carcinoma of the oropharynx

Obata, Atsushi; Eura, Masao; Sasaki, Jiichiro; Saya, Hideyuki; Chikamatsu, Kazuaki; Tada, Mitsuhiro; Iggo, Richard; Yumoto, Eiji

doi:10.1002/(sici)1097-0215(20000320)89:2<187::aid-ijc14>3.0.co;2-v

Cited by 54 publications

(39 citation statements)

References 24 publications

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“…2 In human cancers, accumulation of p53 has been shown to be a good indicator of poor prognosis. 10,13,20 In this study, we found p53 expression in 46% of the 140 tumors investigated, which is lower than the reported 64% 31 but similar to that 23,32 found in head and neck cancers, when examined using the same antibody and cutoff value. Our data, however, confirmed the results of previous studies that failed to establish an association of p53 expression with survival in head and neck cancers.…”

Section: Molecular Marker Expression In Oral Cancer M Shiraki Et Alsupporting

confidence: 62%

“…Our data, however, confirmed the results of previous studies that failed to establish an association of p53 expression with survival in head and neck cancers. 31,32 The absence of an impact of p53 expression on tumor progression might possibly be explained by recent studies that report the predictive value of p53 mutation 33 and mutation within DNA-binding surface region of p53 34 for shortened survival rather than p53 protein expression in head and neck cancers. More comprehensive studies combined with mutational analysis are required for determining the outcomes of cancer patients using immunohistochemistry.…”

Section: Molecular Marker Expression In Oral Cancer M Shiraki Et Almentioning

confidence: 99%

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Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognosis in curatively resected oral cancer

et al. 2005

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p53, cyclin D1 and epidermal growth factor receptor (EGFR) are molecular markers that regulate the cell cycle or cell growth and play important roles in tumor development and progression. In this study, we examined the impact of immunohistochemical expression of these markers on tumor progression in 140 oral cancers. p53, cyclin D1 and EGFR were expressed in 64 cases (46%), 54 cases (39%) and 54 cases (39%), respectively, but there was no inter-relationship between any two of these markers. In the association of these markers with clinicopathological features, EGFR expression alone was significantly associated with poor differentiation (P ¼ 0.0008) and invasive growth pattern (P ¼ 0.0003). Any of these markers, including EGFR, had no significant impact on survival. Coexpression of all these markers, however, was significantly associated with invasive growth pattern (P ¼ 0.0149) and shortened survival (P ¼ 0.0181), and was a significant and independent unfavorable prognostic factor (P ¼ 0.0002), along with tumor size (P ¼ 0.0040), nodal metastasis (P ¼ 0.0137) and growth pattern (P ¼ 0.0017) in a multivariate analysis. Simultaneous coexpression of these markers in oral cancers might prove to be a useful indicator for identification of low-or high-risk patients.

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Section: Molecular Marker Expression In Oral Cancer M Shiraki Et Alsupporting

confidence: 62%

Section: Molecular Marker Expression In Oral Cancer M Shiraki Et Almentioning

confidence: 99%

Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognosis in curatively resected oral cancer

et al. 2005

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“…[32-36] than studies with no association e.g. [38,58,59]. Unfortunately, information on alcohol consumption was lacking in eight patients in our material.…”

Section: Discussionmentioning

confidence: 71%

p53 in head and neck cancer: Functional consequences and environmental implications of TP53mutations

et al. 2010

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BackgroundAlthough TP53 mutations in human tumours generally have been extensively studied, the significance of p53 in the aetiology of head and neck cancers is still incompletely characterized. In recent years, considerable interest has been focused on mutant forms of p53, the abnormal protein product of TP53 alleles with missense mutation that often accumulate in cancer cells.MethodsWe compared the nature of TP53 mutations in primary 46 head and neck squamous cell carcinomas (HNSCC) analyzed by PCR-SSCP and sequencing, immunohistochemistry, and using structural information available at IARC p53 database.ResultsSequencing confirmed 36 TP53 mutations in 23 tumours of the 39 mutations in 26 tumours found by PCR-SSCP. Only half (17) putatively affect the function of p53 protein. Of these 8 were in the L2 domain, three affected the LSH motif and three the L3 domain. Three were in other domains. Codon 259 (GAC > GAA) which is a very rare mutation was found in 4 samples in our study. There were indications of p53 aberrations being associated with the combined effect of smoking, alcohol and work history. Patients with a negative family history of cancer had more often TP53 mutations than patients with a positive family history (71% vs. 46%).ConclusionsOur study contributes to the knowledge of cumulative chemical exposure and p53 aberrations in head and neck cancer, an area where literature is scarce.

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“…Since variations in clinical and/or etiologic behaviors may exist among different sites in the head and neck, analysis for SCC from a single anatomic site should help determine whether a distinct biologic behavior exists. As single site analyses, laryngeal carcinoma, 24,48 oral carcinoma, 25,49,50 and oropharyngeal carcinoma 51 have been analyzed. To our knowledge, the current study is the first report describing the expression of apoptosis-related proteins and p53 mutations in a large number of maxillary sinus SCCs in relation to clinical behaviors.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma

Bandoh

Hayashi

Kishibe

et al. 2002

Cancer

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Clinical significance of p53 functional loss in squamous cell carcinoma of the oropharynx

Cited by 54 publications

References 24 publications

Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognosis in curatively resected oral cancer

Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognosis in curatively resected oral cancer

p53 in head and neck cancer: Functional consequences and environmental implications of TP53mutations

Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma

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