Clinical Significance of Perineural Invasion in Prostate Needle Biopsy in Patients Diagnosed with Extraprostatic Extension and Seminal Vesicle Invasion after Radical Prostatectomy

Bozkurt, Ozan; Çelik, Serdar; Demir, Ömer; Gürboğa, Özgür; Tuna, Burçin; Yörükoğlu, Kutsal; Aslan, Güven

doi:10.4274/uob.274

Cited by 5 publications

(5 citation statements)

References 15 publications

(24 reference statements)

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“…Another study we conducted in recent times investigated local advanced prostate cancer (T3) patients in 3 groups (focal extraprostatic extension, widespread extraprostatic extension and seminal vesicle invasion) and showed the presence of PNI in these groups at rates of 20.4%, 39.5% and 62.2%. The results of the study showed a positive significant correlation between PNI presence and the level of local invasion [20]. A study analyzing the correlation between PNB PNI and RRP surgical margin positivity reported a significant correlation between PNI positivity and surgical margin positivity, similar to our study [21].…”

Section: Discussionsupporting

confidence: 88%

Effects of perineural invasion in prostate needle biopsy on tumor grade and biochemical recurrence rates after radical prostatectomy

Çelik

Bozkurt

Demir

et al. 2018

The Kaohsiung J of Med Scie

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To predict local invasive disease before retropubic radical prostatectomy (RRP), the correlation of perineural invasion (PNI) on prostate needle biopsy (PNB) and RRP pathology data and the effect of PNI on biochemical recurrence (BR) were researched. For patients with RRP performed between 2005 and 2014, predictive and pathologic prognostic factors were assessed. Initially all and D'Amico intermediate-risk group patients were comparatively assessed in terms of being T2 or T3 stage on RRP pathology, positive or negative for PNI presence on PNB and positive or negative BR situation. Additionally the effect of PNI presence on recurrence-free survival (RFS) rate was investigated. When all patients are investigated, multivariate analysis observed that in T3 patients PSA, PNB Gleason score (GS) and tumor percentage were significantly higher; in PNI positive patients PNB GS, core number and tumor percentage were significantly higher and in BR positive patients PNB PNI positivity and core number were significantly higher compared to T2, PNI negative and BR negative patients, separately (p < 0.05). When D'Amico intermediate-risk patients are evaluated, for T3 patients PSA and PNB tumor percentage; for PNI positive patients PNB core number and tumor percentage; and for BR positive patients PNB PNI positivity were significantly higher compared to T2, PNI negative and BR negative patients, separately (p < 0.05). Mean RFS in the whole patient group was 56.4 ± 4.2 months for PNI positive and 96.1 ± 5.7 months for negative groups. In the intermediate-risk group, mean RFS was 53.7 ± 5.1 months for PNI positive and 100.3 ± 7.7 months for negative groups (p < 0.001). PNI positivity on PNB was shown to be an important predictive factor for increased T3 disease and BR rates and reduced RFS.

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Section: Discussionsupporting

confidence: 88%

Effects of perineural invasion in prostate needle biopsy on tumor grade and biochemical recurrence rates after radical prostatectomy

Çelik

Bozkurt

Demir

et al. 2018

The Kaohsiung J of Med Scie

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“…Bu faktörlerden en önemlilerini klinik evre, prostat spesifik antijen (PSA) ve biyopsi Gleason skoru oluşturmaktadır (2,3,4). Bu belirteçler dışında özellikle prostat iğne biyopsisindeki ekstraprostatik yayılım ve perinöral invazyon (PNİ) bulgusu ile hormonal değerlendirmelerden olan total testosteron (TTE), folikül stimüle edici hormon (FSH) ve lüteinizan hormon (LH) araştırılmış ve çalışmalarda farklı sonuçlar saptanmıştır (5,6,7,8). TTE ile prostat kanseri arasındaki ilişkiyi inceleyen çalışmalarda farklı sonuçlar raporlanmışsa da özellikle düşük TTE düzeyinin prostat kanseri tedavisinde yanıtta azalma, kötü prognoz ve metastatik hastalıkla ilişkili olabileceği yönünde görüşler belirtilmiştir (9,10).…”

Section: Introductionunclassified

Association between Hormonal Evaluation Before Prostate Needle Biopsy and Locally Advanced Prostate Cancer

Çelik¹,

Bozkurt²,

Yıldız³

et al. 2016

uob

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“…Of the other parameters studied, findings of perineural invasion (PNI), number of positive biopsy cores, and tumor percentage in PNB are also important (4,5). Numerous studies have investigated the association between locally advanced disease and pre-treatment levels of free testosterone (fTE), estradiol (EST), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and especially total testosterone (TTE) (4,6,7,8,9,10). Therefore, in this study we evaluated patients who underwent retropubic radical prostatectomy (RRP) in our clinic due to PCa and had pre-PNB hormone data.…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of Hormonal Evaluation Before Prostate Needle Biopsy on Prostate Cancer T Stage and Prognosis

Çelik¹,

Yörükoğlu²,

Bozkurt³

et al. 2018

uob

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In this study we evaluated the hormone data before prostate needle biopsy (PNB) in patients who underwent retropubic radical prostatectomy (RRP) due to prostate adenocarcinoma (PCa). Correlations between the patients' RRP pathology results, recurrence-free survival (RFS), and hormone data were investigated. Materials and Methods: Patients were evaluated in two groups according to RRP pathologic T stage: T2 (group 1) and T3 (group 2). Then patients were assessed in two groups based on total testosterone (TTE) values: >300 ng/dL and <300 ng/dL. The preoperative data, hormone data, RRP pathologic data, and biochemical recurrence and RFS results were compared between these groups. Results: A total of 81 patients were evaluated. The mean follow-up time was 37.7 months. Mean recurrence free survival (RFS) among all patients was 94.2±7 months. In multivariate analysis of the preoperative data, TTE/prostate volume (p=0.015) and PNB tumor percentage (p=0.004) were significantly higher in group 2 (n=32) compared to group 1 (n=49). In the postoperative data, RRP pathology Gleason score (GS) (p=0.015) and tumor volume (p=0.02) were significantly higher in group 2. RFS was 99.2±5.8 months in group 1 and 77±12.1 months in group 2 (p=0.02). When patients were assessed according to TTE levels, of the pre-and postoperative data only RRP pathology T stage, GS, and lymph node positivity were significantly higher in the TTE <300 ng/dL group (n=30) compared to the TTE >300 ng/dL group (n=51). The biochemical recurrence rates and RFS times (87.7±13.8 months and 91.3±6.4 months, respectively) were similar between the groups (p=0.571). Conclusion: We demonstrated a correlation between locally invasive PCa and low TTE measured before PNB and low TTE density. In particular, TTE values <300 ng/dL were associated with high pathologic T stage, GS, and lymph node positivity.

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Clinical Significance of Perineural Invasion in Prostate Needle Biopsy in Patients Diagnosed with Extraprostatic Extension and Seminal Vesicle Invasion after Radical Prostatectomy

Cited by 5 publications

References 15 publications

Effects of perineural invasion in prostate needle biopsy on tumor grade and biochemical recurrence rates after radical prostatectomy

Effects of perineural invasion in prostate needle biopsy on tumor grade and biochemical recurrence rates after radical prostatectomy

Association between Hormonal Evaluation Before Prostate Needle Biopsy and Locally Advanced Prostate Cancer

Predictive Value of Hormonal Evaluation Before Prostate Needle Biopsy on Prostate Cancer T Stage and Prognosis

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