Clinical Significance of Platelet Antigen 1/Platelet Antigen 2 (PlA1/A2) Polymorphism of Integrin b3 (ITGB3) Gene in Coronary Artery Disease

Bawady, Hala Abdel Al Somia A.; Kilany, Azza A. Saab Wael El; Metwally, Ahmed S. Allam Shaimaa S.

doi:10.21608/mjcu.2019.70350

The Medical Journal of Cairo University

2019

DOI: 10.21608/mjcu.2019.70350

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Clinical Significance of Platelet Antigen 1/Platelet Antigen 2 (PlA1/A2) Polymorphism of Integrin b3 (ITGB3) Gene in Coronary Artery Disease

Hala Abdel Al Somia A. Bawady¹,

Azza A. Saab Wael El Kilany²,

Ahmed S. Allam Shaimaa S. Metwally

Abstract: Background: Coronary Artery disease (CAD) is the leading cause of death worldwide. Platelet activation and aggregation play a crucial role in the process of arterial thrombosis; the main pathogenesis of the disease. The major membrane protein on platelet is integrin α IIb β 3 which mediates this response by rapidly transiting from its resting to an activated state in which it serves as a receptor for ligands that can bridge platelets together.

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2024

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Frequency of CYP2C19, P2RY12, ITGB3, ITGA2, and eNOS3 gene polymorphism in patients with myocardial infarction

Pronko,

Snezhitskiy,

Stsiapura

et al. 2024

Vescì Nac. akad. navuk Belarusì, Ser. med. navuk

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The aim of the study was to assess the distribution of polymorphic variants G681A (*2) of the CYP2C19 gene, H1/H2 of the P2RY12 gene, T1565C of the ITGB3 gene, C807T of the ITGA2 gene, and T786C of the eNOS3 gene in the population of the Grodno region, and to study their associations with myocardial infarction (MI). The study of the population consists of 493 people, including 400 patients with MI aged 31 to 74 years and 93 people of the control group aged 32 to 60 years. Research data (clinical and genotyping performed by polymerase chain reaction) were analyzed using STATISTICA 10.0 software. The prevalence of carriage of genotypes associated with high residual platelet reactivity and variability in response to dual antiplatelet therapy among patients with MI was 25.2 % for the G681A polymorphic locus of the CYP2C19 gene (GA + AA), and for the H1/H2 polymorphic locus of the P2RY12 gene (H1/H2 + H2/H2) – 40.0 %, for the C807T polymorphic locus of the ITGA2 gene (CT + TT) – 65.8, for the T1565C polymorphic locus of the ITGB3 gene (TC + CC) – 25.5, for the polymorphic locus T786C of the eNOS gene (TC + CC) – 69.2 %. Among the individuals of the control group, the frequency of occurrence of these genotypes was 18.3, 46.2, 60.2, 37.6, 48.4 %, respectively. In patients with MI, compared to the control group, the TT genotype of the eNOS gene was less common (χ2 = 13.6, p = 0.0002), the CC genotype of the eNOS gene (χ2 = 5.4, p = 0.02) and the allele 786C of the eNOS gene (χ2 = 15.1, p = 0.0001) were more often detected. The carriage of the 786C allele of the eNOS gene increased the risk of MI in the studied population (OR = 2.0, 95 % CI: 1.41‒2.82, p = 0.0001). Gender differences were not found in the distribution of genotypes and alleles within the studied groups. There were no differences in carriage by the number of combinations of minor alleles between the control group and patients with MI. The most common combinations of minor alleles in both groups were comparable.

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Frequency of CYP2C19, P2RY12, ITGB3, ITGA2, and eNOS3 gene polymorphism in patients with myocardial infarction

Pronko,

Snezhitskiy,

Stsiapura

et al. 2024

Vescì Nac. akad. navuk Belarusì, Ser. med. navuk

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Clinical Significance of Platelet Antigen 1/Platelet Antigen 2 (PlA1/A2) Polymorphism of Integrin b3 (ITGB3) Gene in Coronary Artery Disease

Cited by 1 publication

References 16 publications

Frequency of CYP2C19, P2RY12, ITGB3, ITGA2, and eNOS3 gene polymorphism in patients with myocardial infarction

Frequency of CYP2C19, P2RY12, ITGB3, ITGA2, and eNOS3 gene polymorphism in patients with myocardial infarction

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