Clinical Significance of Reporting Benign-Appearing Endometrial Cells in Pap Tests in Women Aged 40 Years and Over

Jones, Elizabeth H.; Frain, Barbara McGahey; Crabtree, William N.

doi:10.1159/000325080

Cited by 6 publications

(7 citation statements)

References 9 publications

(12 reference statements)

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“…To be even more precise, BECs are statistically predictors of only “simple hyperplasia without atypia” ( P ‐value = 0.05) among the hyperplastic lesions (Tables I and II). Our conclusion, in this series, is the same as Thrall et al (3, Table IV) in a similarly designed double‐arm study 18. Combined data from Thrall's study and the current series (Table V) maintain comparable statistical significances as in Table III.…”

Section: Discussionsupporting

confidence: 87%

“…The higher percentage of SUPs in this series as compared with that in other series may be related to the sampling and selection methodology of the cases (6, Table IV). With a similar conclusion, in 2009, Jones et al (2, Table IV) reviewed 149 patients who had BECs in their Pap smears of whom 5 (3.5%) had endometrial adenocarcinoma in subsequent biopsies and all had AUB prior to their surgical procedures 18. Numerical details of these studies are list in Table IV.…”

Section: Discussionmentioning

confidence: 89%

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In Papanicolaou smears, benign appearing endometrial cells bear no significance in predicting uterine endometrial adenocarcinomas

Moatamed

Levin

et al. 2011

Diagnostic Cytopathology

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Reporting of benign appearing endometrial cells (BECs) in the Papanicolaou smears of women aging 40 years or older was mandated in the Bethesda System 2001 aiming at predicting the uterine pathology. The purpose of this study was to determine the clinical significance of the BECs in patients in our Medical Center. A two-arm study was designed in ≥40-years-old women with BECs and without BECs in their Pap smears from January 2002 to December 2004. Of 21,965 patients, 882 had BECs in their Pap smears and the rest did not. Among the patients with BECs, 186 (study group) and among those without BECs, 2,064 (control group) had histopathologic follow-ups. There were 4 patients in the study and 47 in the control groups who had uterine adenocarcinoma. The Chi-square P-value for adenocarcinoma between the two groups was 0.91; indicating insignificant differences between the two groups. We conclude that presence of BECs in the Pap smears of ≥40-years-old women signal no significance as a harbinger of endometrial adenocarcinoma.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 89%

In Papanicolaou smears, benign appearing endometrial cells bear no significance in predicting uterine endometrial adenocarcinomas

Moatamed

Levin

et al. 2011

Diagnostic Cytopathology

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“…Routine biopsy after E40 may lead to unnecessary procedures, risks for the patient and healthcare costs . Establishing a different age threshold in combination with other clinical findings was raised by many studies including the current one that may help to avoid unnecessary procedures and guide management and follow‐up . In fact, many clinicians feel that this diagnosis creates confusion and management challenges …”

mentioning

confidence: 99%

“…16 Establishing a different age threshold in combination with other clinical findings was raised by many studies including the current one that may help to avoid unnecessary procedures and guide management and follow-up. 15,[17][18][19][20][21][22] In fact, many clinicians feel that this diagnosis creates confusion and management challenges. 15,23 In the current study, we explored the significance of E40 identified on a cytology Pap test in identifying EC.…”

mentioning

confidence: 99%

Age cut-off for reporting endometrial cells on a Papanicolaou test: 50 years may be more appropriate than 45 years

et al. 2015

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“…Jones et al (20) have evaluated 143 cases and discovered benign pathological changes in 51 (35.66%) cases. These changes included endometrial polyp, simple hyperplasia, atypical hyperplasia, leiomyoma, adenomyosis, atypical clear cell, adenomyosis with leiomyoma, polyp with leiomyoma, hyperplastic polyp, polyp with adenomyosis in respectively 23, 8, 2, 6, 1, 1, 5, 2, 2 and 1 cases.…”

Section: Discussionmentioning

confidence: 99%

The Role of Papanicolaou Test in the Diagnosis of Endometrial Carcinoma

Turan

Usta²

2019

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Amaç: Pap smear testi, serviks kanseri ve öncü lezyonlarını taramak için en sık kullanılan ve etkili bir tarama yöntemidir. Endometrial karsinomların tanısında Pap smear testinin kullanımı ile ilgili çok az çalışma vardır. Biz bu çalışmada endometrial karsinom tanısı almış hastaların Pap smearlerinde atipik endometrial hücrelerin bulunma oranını ve klinikopatolojik parametrelerle korelasyonunu araştırmayı amaçladık. Hastalar ve Yöntem: Bu çalışmada Ocak 2015-Eylül 2017 yılları arasında endometrial karsinom tanısı konulmuş ve aynı zamanda Pap smear örneklemesi yapılmış hastalar retrospektif olarak incelenmiştir. Endometrial karsinom olgularının histolojik tip, nükleer derece ve Pap smear sonuçları değerlendirilmiştir. Bulgular: Çalışmaya dahil edilen endometrial karsinom tanısı konulmuş 97 hastanın 59'una aynı zamanda smear örneklemesi yapılmıştı. Smear örneklemesi yapılan hastaların yaşları 42-82 yaş aralığındaydı (ortalama57,43±9,08). Hastaların menopoz durumu değerlendirildiğinde 12'si (%20.3) premenopozal ve 47'si (%79.7) postmenopozal durumdaydı. En sık görülen histolojik tip endometrioid olup 51 hastada izlendi (%86.4). 6 hastada seröz (%10), 1 hastada şeffaf hücreli (%1.8) ve 1 hastada müsinöz karsinom (%1.8) mevcuttu. Pap smear sonucu 24 hastada atipik iken (%40.7), 35 hastada normaldi (%59.3). Nükleer derece değerlendirildiğinde 24 hastada derece 1 (%40.7), 25 hastada derece 2 (%42.3), 10 hastada derece 3'tü (%17). Tümör derecesi arttıkça Pap smearlerde atipik endometrial hücre görülme oranı artmaktaydı. Sonuç: Endometrial karsinomlarda pap smear de atipik hücre saptama oranlarının azımsanmayacak kadar yüksek olduğu görüldü. Nonendometrioid ve yüksek dereceli karsinomlarda atipik hücre görülme oranları daha fazlaydı.

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Clinical Significance of Reporting Benign-Appearing Endometrial Cells in Pap Tests in Women Aged 40 Years and Over

Cited by 6 publications

References 9 publications

In Papanicolaou smears, benign appearing endometrial cells bear no significance in predicting uterine endometrial adenocarcinomas

In Papanicolaou smears, benign appearing endometrial cells bear no significance in predicting uterine endometrial adenocarcinomas

Age cut-off for reporting endometrial cells on a Papanicolaou test: 50 years may be more appropriate than 45 years

The Role of Papanicolaou Test in the Diagnosis of Endometrial Carcinoma

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