Clinical significance of ribosome production factor 2 homolog in hepatocellular carcinoma

An, Yan; Xia, Yechen; Wang, Zhengyang; Jin, Guang-Zhi; Shang, Mingyi

doi:10.1016/j.clinre.2024.102289

Clinics and Research in Hepatology and Gastroenterology

2024

DOI: 10.1016/j.clinre.2024.102289

|View full text |Cite

Clinical significance of ribosome production factor 2 homolog in hepatocellular carcinoma

Yan An,

Yechen Xia,

Zhengyang Wang

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Preprint1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Association between ribosomal protein gene dysregulation and tumor biodiversity of hepatocellular carcinoma

Lu,

Xu,

Zhao

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Tumor cells are characterized by a higher production of ribosomes, which are necessary for maintaining enhanced cell growth and subsequent cell division. An increase in ribosome production is associated with aberrant ribosome biogenesis homeostasis; these elements represent specific hallmarks of cancer cells. However, its association with the hepatocellular carcinoma (HCC) microenvironment remains poorly understood. Methods Using single-sample gene set enrichment analysis (ssGSEA), we constructed an RPLscore to estimate the dysregulation of ribosomal protein large (RPL) genes. The expression of RPL genes and their association with clinical outcomes and the tumor microenvironment (TME) were systematically investigated using bulk-seq and single-cell RNA-seq (scRNA-seq). Results We observed that HCC with high expression levels of RPL was associated with poorer overall survival (OS) (P < 0.001). We developed an RPL score to evaluate the RPL gene and verified its independent prognostic value for both OS and relapse-free survival (P = 0.0074 and P < 0.001, respectively). TME analysis indicated that RPL gene dysregulation was closely associated with T cell exhaustion, myeloid-derived suppressor cell (MDSC) infiltration, and vascular dysplasia may be promoted by arginine deficiency (P = 7.6 × 10–10). The scRNA-seq data concerning HCC suggested that the RPL score was positively and significantly associated with the tumor biodiversity score (ITH score). Conclusion The present study highlights the prognostic value of the RPL score and its potential role in mediating immune evasion of HCC, which may provide an impetus for the development of new targets for the treatment of HCC.

show abstract

Association between ribosomal protein gene dysregulation and tumor biodiversity of hepatocellular carcinoma

Lu,

Xu,

Zhao

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Clinical significance of ribosome production factor 2 homolog in hepatocellular carcinoma

Cited by 1 publication

References 30 publications

Association between ribosomal protein gene dysregulation and tumor biodiversity of hepatocellular carcinoma

Association between ribosomal protein gene dysregulation and tumor biodiversity of hepatocellular carcinoma

Contact Info

Product

Resources

About