Clinical significance of sarcoid‐like reaction in lymph nodes of gastric cancer patients

Itai, Y; Ueda, Y.; Etoh, Tsuyoshi; Shirasaka, Yoshinori; Shiroshita, Hidefumi; Shiraishi, Norio; Daa, Tsutomu; Ito, Masafumi

doi:10.1002/jso.26525

Cited by 4 publications

(1 citation statement)

References 31 publications

(49 reference statements)

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“…A granulomatous sarcoid like reaction (SLR) can be found admixed with the tumor or in the draining lymph nodes [18]. In fact, some investigators suggest the presence of a granulomatous reaction associated with tumor is a marker for a good immunologic response and better prognosis [19,20].…”

Section: Published Studies Supporting An Association Between Cancer A...mentioning

confidence: 99%

Sarcoidosis and maligancy: the chicken and the egg?

Bonifazi¹,

Renzoni

Lower

2021

Current Opinion in Pulmonary Medicine

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Purpose of reviewThere is a complex interaction between sarcoidosis and malignancy. Since tumors can elicit a granulomatous reaction, the presence of granulomas alone is insufficient to diagnose sarcoidosis in a patient with cancer. In addition, check point inhibitors can also lead to a granulomatous reaction which can be misdiagnosed as sarcoidosis. These issues need to be considered when exploring the relationship between sarcoidosis and malignancy. Despite these limitations, a growing amount of evidence supports the potential interaction of sarcoidosis and malignancy.Recent findingsSeveral large epidemiologic studies of patients from Europe, the USA, and Japan reveal an increased relative risk for cancer in sarcoidosis patients. The highest relative risks are seen in patients with lymphoma and breast cancer. New criteria have been developed to standardize the diagnosis of sarcoidosis, which should further clarify the association.SummaryThe diagnosis of sarcoidosis may precede or occur after malignancy. In a sarcoidosis patient with an atypical lesion, such as a breast mass, a biopsy should be considered.

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Section: Published Studies Supporting An Association Between Cancer A...mentioning

confidence: 99%

Sarcoidosis and maligancy: the chicken and the egg?

Bonifazi¹,

Renzoni

Lower

2021

Current Opinion in Pulmonary Medicine

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The clinical importance of the host anti-tumour reaction patterns in regional tumour draining lymph nodes in patients with locally advanced resectable gastric cancer: a systematic review and meta-analysis

Budginaite,

Kloft,

van Kuijk

et al. 2023

Gastric Cancer

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Background The status of regional tumour draining lymph nodes (LN) is crucial for prognostic evaluation in gastric cancer (GaC) patients. Changes in lymph node microarchitecture, such as follicular hyperplasia (FH), sinus histiocytosis (SH), or paracortical hyperplasia (PH), may be triggered by the anti-tumour immune response. However, the prognostic value of these changes in GaC patients is unclear. Methods A systematic search in multiple databases was conducted to identify studies on the prognostic value of microarchitecture changes in regional tumour-negative and tumour-positive LNs measured on histopathological slides. Since the number of GaC publications was very limited, the search was subsequently expanded to include junctional and oesophageal cancer (OeC). Results A total of 28 articles (17 gastric cancer, 11 oesophageal cancer) met the inclusion criteria, analyzing 26,503 lymph nodes from 3711 GaC and 1912 OeC patients. The studies described eight different types of lymph node microarchitecture changes, categorized into three patterns: hyperplasia (SH, FH, PH), cell-specific infiltration (dendritic cells, T cells, neutrophils, macrophages), and differential gene expression. Meta-analysis of five GaC studies showed a positive association between SH in tumour-negative lymph nodes and better 5-year overall survival. Pooled risk ratios for all LNs showed increased 5-year overall survival for the presence of SH and PH. Conclusions This systematic review suggests that sinus histiocytosis and paracortical hyperplasia in regional tumour-negative lymph nodes may provide additional prognostic information for gastric and oesophageal cancer patients. Further studies are needed to better understand the lymph node reaction patterns and explore their impact of chemotherapy treatment and immunotherapy efficacy.

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Hematologic and Oncologic Aspects of Sarcoidosis

Lower,

Baughman

2024

Clinics in Chest Medicine

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Clinical significance of sarcoid‐like reaction in lymph nodes of gastric cancer patients

Cited by 4 publications

References 31 publications

Sarcoidosis and maligancy: the chicken and the egg?

Sarcoidosis and maligancy: the chicken and the egg?

The clinical importance of the host anti-tumour reaction patterns in regional tumour draining lymph nodes in patients with locally advanced resectable gastric cancer: a systematic review and meta-analysis

Hematologic and Oncologic Aspects of Sarcoidosis

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