Clinical Significance of Selenium Level in Chronic Pancreatitis

Uehara, Soichiro; Honjo, Kyosuke; Hirano, Fuminori; Sakai, Norio; Hirayama, Akio; Jin, Kazuo

doi:10.3164/jcbn.5.201

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…We found a positive and significant correlation of plasma Se and plasma GSH-Px as well as between whole blood Se concentration and red cell GSH-Px activity. Similar correlations have been reported previously for healthy subjects [54,60], pregnant women [71], and in different kinds of cancer patients [1,18,41,57,65]. In some other studies a weak, nonsignificant correlation between these parameters has been shown [32,55,58,61].…”

Section: Blood Gsh-px Activitiessupporting

confidence: 71%

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Decreased Selenium Concentration and Glutathione Peroxidase Activity in Blood and Increase of These Parameters in Malignant Tissue of Lung Cancer Patients

Zachara

Marchaluk-Wiśniewska

Maciąg

et al. 1997

Lung

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We studied the selenium (Se) concentration in whole blood and plasma, glutathione peroxidase (GSH-Px) activity in red blood cells and plasma, as well as both of these parameters in cancerous and tumor-free lung tissue of lung cancer patients. Blood samples were taken from 84 cancer patients and 61 healthy controls. Normal and neoplastic lung tissues were obtained from 57 patients at the time of surgery. Se concentrations in whole blood and plasma were lower by 23% (p < 0.001) in patients compared with controls. GSH-Px activity in red cells was lower by 20.2% (p < 0.004) and in plasma by 11.7% (p < 0.05) in patients than in the control group. On the other hand, the tumor Se level was higher by 66.6% (p < 0.0001) and GSH Px activity by 49.5% (p < 0.0001) than in adjacent tumor-free tissue. No differences in Se concentrations and GSH-Px activities were found between squamous cell carcinoma and adenocarcinoma nor among the clinical stages of the disease. In the whole blood and plasma of cancer patients significantly lower Se concentrations were found in smokers than in nonsmokers. Significantly lower Se concentrations were also found among cancer patients who were smokers compared with controls. These findings show that in the blood of cancer the antioxidant ability, as measured by Se and GSH-Px, is reduced significantly. The cause of increased Se and GSH-Px in the malignant part of the lung is not understood and requires further studies.

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Section: Blood Gsh-px Activitiessupporting

confidence: 71%

“…Several studies [41,57], but not all [1], presented significantly lower GSH-Px activities in red cells and/or plasma of cancer patients. Some other groups have shown significantly [7] or nonsignificantly higher red cell [18,19] and plasma [1,65] GSH-Px activities in cancer patients.…”

Section: Blood Gsh-px Activitiesmentioning

confidence: 99%

Decreased Selenium Concentration and Glutathione Peroxidase Activity in Blood and Increase of These Parameters in Malignant Tissue of Lung Cancer Patients

Zachara

Marchaluk-Wiśniewska

Maciąg

et al. 1997

Lung

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Selenium in global food systems

2001

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Food systems need to produce enough of the essential trace element Se to provide regular adult intakes of at least 40 m g/d to support the maximal expression of the Se enzymes, and perhaps as much as 300 m g/d to reduce risks of cancer. Deprivation of Se is associated with impairments in antioxidant protection, redox regulation and energy production as consequences of suboptimal expression of one or more of the Secontaining enzymes. These impairments may not cause deficiency signs in the classical sense, but instead contribute to health problems caused by physiological and environmental oxidative stresses and infections. At the same time, supranutritional intakes of Se, i.e. intakes greater than those required for selenocysteine enzyme expression, appear to reduce cancer risk. The lower, nutritional, level is greater than the typical intakes of many people in several parts of the world, and few populations have intakes approaching the latter, supranutritional, level. Accordingly, low Se status is likely to contribute to morbidity and mortality due to infectious as well as chronic diseases, and increasing Se intakes in all parts of the world can be expected to reduce cancer rates.

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Clinical Significance of Selenium Level in Chronic Pancreatitis

Abstract: SummaryBlood selenium concentrations were found to be significantly

Cited by 2 publications

References 19 publications

Decreased Selenium Concentration and Glutathione Peroxidase Activity in Blood and Increase of These Parameters in Malignant Tissue of Lung Cancer Patients

Decreased Selenium Concentration and Glutathione Peroxidase Activity in Blood and Increase of These Parameters in Malignant Tissue of Lung Cancer Patients

Selenium in global food systems

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