Clinical significance of serum and tumor tissue endostatin evaluation in operable non-small cell lung cancer

Abstract

Abstract. Endostatin, as the most potential antiangiogenic factor, is a naturally occurring fragment of collagen XVIII in bloodstream capable of inhibiting tumor growth and metastasis. This study was conducted to explore the clinical value of endostatin in serum and tumor tissue in patients with operable non-small cell lung cancer (NSCLC). ELISA and immunohistochemistry were applied to detect the expression of endostatin in serum and tumor tissue in 105 patient-matched operable NSCLC patients. The serum level of endostatin was significantly higher in NSCLC patients than healthy individuals (P=0.0018). Cases with poorer differentiation showed a higher endostatin serum level (P=0.008). There was no significant correlation between tumor tissue expression and clinical parameters, such as TNM stage, differentiation degree, histological type and lymph node invasion status. A stronger expression of endostain in tumor tissue was associated with a higher serum level (r=0.223). The univariate and multivariate analyses with Cox proportional hazards model for overall survival showed that tumor stage and node status were independent prognostic factors, whereas neither endostatin levels in serum nor in tumor tissue showed potential in predicting the long-term survival of operable NSCLC patients. In conclusion, the results observed in the present study did not support the prediction of overall survival in operable NSCLC based on the expression levels of endostatin in serum and tumor tissue.

Recombinant Bifidobacterium longum Carrying Endostatin Protein Alleviates Dextran Sodium Sulfate-Induced Colitis and Colon Cancer in Rats

“…Recombinant endostatin has been considered as a broad-spectrum anticancer agent because of its endogenous inhibitory effect on angiogenesis, non-toxicity, and synergistic ability with chemotherapy drugs ( Boehm et al, 1997 ; Folkman, 2006 ; Zhuang and Yuan, 2009 ). Currently, recombinant endostatin (Endostar) has been approved for the treatment of NSCLC by the State Food and Drug Administration of China, which is expressed and purified in E. coli with an additional nine-amino acid sequence ( Hu et al, 2014 ). However, its short half-life and instability limit clinical applications.…”

The rs3957357C>T SNP in GSTA1 Is Associated with a Higher Risk of Occurrence of Hepatocellular Carcinoma in European Individuals

“…Here, we showed that GSTA1 mRNA expression was down-regulated in HCCs with respect to non-tumor tissues. Importantly, low GSTA1 expression in HCCs was proportional to high tumor size and low expression of the liver-enriched genes albumin [36] and procollagen type XVIII [37]. In addition, GSTA1 expression, in an independent set of 247 HCCs, was associated with the expression of liver-enriched genes, such as HNF4A, MAT1A, SDS, ARG1 as well as of several members of the cytochrome P450 family involved in well-differentiated hepatocyte-specific metabolic functions.…”