Clinical significance of serum laminin levels in patients with lung cancer

Abstract

Abstract. Cellular adhesion molecules are considered useful markers in the diagnosis and prognosis of several types of malignant tumors. Laminin, a major structural component of the basement membrane, is a strong promoter of cell adhesion, migration, differentiation and proliferation via integrins and other cell surface receptors. The present study aimed to evaluate the clinical significance of the serum level of laminin in lung cancer patients. A total of 80 patients with lung cancer were enrolled in the study. The serum laminin level was measured by the solid-phase sandwich enzyme-linked immunosorbent assay method. The median age was 58.5 years (range, 36-80 years). The majority of the patients had non-small cell lung carcinoma (85%) and stage IV disease (56%). The baseline serum laminin levels of patients were significantly higher compared to the control group (median values 1.17 vs. 0.78 ng/ml, P=0.033). However, the clinical variables, such as age, gender, histology, stage of disease and response to chemotherapy, were not correlated with serum laminin level (P>0.05). Similarly, serum laminin level was not associated with survival (P=0.68). In conclusion, the serum level of laminin may have a diagnostic value in lung cancer patients. However, its predictive and prognostic roles were not observed.

Downregulation of TRIM28 inhibits growth and increases apoptosis of nude mice with non‑small cell lung cancer xenografts

“…Halvorsen et al ( 22 ) validated six microRNAs (miR-429, miR-205, miR-200b, miR-203, miR-125b, and miR-34b) that were candidate biomarkers for future screening detection, because their abundance in the serum of NSCLC patients was significantly higher than that in chronic obstructive pulmonary diseases (COPD) patients and healthy volunteers. The serum laminin levels measured by solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) were significantly higher in NSCLC patients, and this method might be promising as a diagnostic supplement ( 23 ). The level of four serum markers (CEA, CYFRA21-1, NSE and miR-21) was measured in 50 NSCLC patients and 60 healthy donors, and the results indicated that serum miR-21 had the highest diagnostic value, whereas the combination of miR-21 and CYFRA21-1 improved the diagnostic efficiency for early NSCLC ( 24 ).…”

Research progress on gel-based nanocomposites for diagnosis and treatment of respiratory diseases

“…Serum tumor markers, such as Carcinoembryonic antigen (CEA), Cytokeratin 19 fragment (CYFRA21-1) and Neuron-specific enolase (NSE), are non-invasive tests that can aid the diagnosis of primary lung cancer. [59][60][61][62] The treatment approach for lung cancer should be based on factors such as the patient's physical condition, pathological type, molecular pathological diagnosis, and clinical stage. Treatment options include surgery, chemotherapy, targeted therapies, immunotherapy and radiotherapy.…”