Clinical significance of serum urea‐to‐creatinine ratio in patients undergoing peritoneal dialysis

Tonomura, Shun; Uchiyama, Kiyotaka; Nakayama, Takashin; Mitsuno, Ryunosuke; Kojima, Daiki; Hama, Eriko Yoshida; Nagasaka, Tomoki; Nishimura, Erina Sugita; Kusahana, Ei; Takahashi, Rina; Yoshimoto, Norifumi; Yamaguchi, Shintaro; Morimoto, Kohkichi; Yoshida, Tadashi; Hayashi, Kaori; Kanda, Takeshi; Washida, Naoki; Itoh, Hiroshi

doi:10.1111/1744-9987.14030

Ther Apher Dial

2023

DOI: 10.1111/1744-9987.14030

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Clinical significance of serum urea‐to‐creatinine ratio in patients undergoing peritoneal dialysis

Shun Tonomura

Kiyotaka Uchiyama

Takashin Nakayama

et al.

Abstract: IntroductionWe aimed to determine the correlation between the serum urea‐to‐creatinine ratio and residual kidney function (RKF) in patients undergoing peritoneal dialysis (PD), as well as its predictive value for PD‐related outcomes.MethodsThis study included a cross‐sectional study to assess the correlation between serum urea‐to‐creatinine ratio and RKF in 50 patients on PD and a retrospective cohort study to assess the association between serum urea‐to‐creatinine ratio and PD‐related outcomes in 122 patients… Show more

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2024

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Cited by 2 publications

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Prognosis and characteristics of Corynebacterium exit site infection: a single-center retrospective study

Sugita,

Washida,

Takahashi

et al. 2024

Ren Replace Ther

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Background Corynebacterium is a rare but important cause of peritoneal dialysis (PD)-associated infection. A previous study reported that continued antibiotic use at the exit site is associated with increased Corynebacterium exit site infection (ESI), although the latest International Society of Peritoneal Dialysis guideline recommends its use. This study aims to verify the prognosis of Corynebacterium-associated PD-related infections, focusing on ESI. Methods We conducted a single-center, retrospective study about ESI, tunnel infection (TI), and PD-associated peritonitis due to Corynebacterium between April 2018 and January 2023. We primarily examined the prognosis and characteristics of Corynebacterium ESI. Results In this study, we included 125 patients with PD (mean age at PD onset: 69.4 ± 13.7 years, 71.2% male, 48% diabetic, mean estimated glomerular filtration rate at the introduction of PD 7.4 ± 2.6 ml/min/1.73 m2, total follow-up 179.6 patient dialysis year). Between April 2018 and January 2023, 191 cases of ESI, 62 cases of Corynebacterium ESI in 24 patients, 10 cases of TI, and 32 cases of PD-associated peritonitis were detected. In total, 16 of 24 patients with Corynebacterium-associated ESI tested positive for Corynebacterium multiple times in cultures against the exit site, with a maximum of eight times. The estimated glomerular filtration rate during PD introduction was relatively lower in patients with Corynebacterium-associated ESI than in patients without ESI (6.4 versus 7.9 mL/min/1.73 m2, respectively; P = 0.052). Although three of the Corynebacterium ESI cases progressed to TI, there were no cases that progressed directly to PD-associated peritonitis. Conclusions Corynebacterium-associated ESI progresses to TI with a certain probability; however, it is thought that it rarely progresses to PD-associated peritonitis directly.

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Prognosis and characteristics of Corynebacterium exit site infection: a single-center retrospective study

Sugita,

Washida,

Takahashi

et al. 2024

Ren Replace Ther

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Determination of urea, creatinine and urea/creatinine ratios in calves with diarrhoea

Yanar,

Aktaş,

Özcan

2024

Harran Üniversitesi Veteriner Fakültesi Dergisi

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The objective of this study was to ascertain the levels of urea, creatinine (Crea) and the urea/creatinine ratio (UCR) in calves presenting with diarrhoea. The study material comprised 20 calves with diarrhoea and 10 healthy controls. Once the aetiology of diarrhoeal calves had been determined, blood samples were taken and urea, creatinine and UCR levels were determined. The findings of the study indicated that the levels of urea and UCR were statistically significantly elevated in calves with diarrhoea in comparison to the control group. However, the increase in creatinine level was statistically insignificant. The results of the study revealed that UCR is an important biomarker in the evaluation of renal failure in calves with diarrhoea.

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Clinical significance of serum urea‐to‐creatinine ratio in patients undergoing peritoneal dialysis

Cited by 2 publications

References 38 publications

Prognosis and characteristics of Corynebacterium exit site infection: a single-center retrospective study

Prognosis and characteristics of Corynebacterium exit site infection: a single-center retrospective study

Determination of urea, creatinine and urea/creatinine ratios in calves with diarrhoea

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