Clinical Significance of Some Acute Phase Proteins in Cattle

Abstract

Acute phase proteins are proteins synthesized by the liver in response to the acute phase response. While these proteins are insignificant in healthy animals, their concentrations increase rapidly during infection, inflammation, or tissue damage and are used as an indicator of inflammation. Since the blood concentrations and importance levels of these clinically important proteins differ according to the animal species, they are evaluated separately for each animal species. Most of the acute phase proteins have been studied in detail in the field of human medicine and are routinely used in the diagnosis and prognosis of diseases. In the field of veterinary medicine, it has not been used sufficiently. In this book chapter, we will provide up-to-date information about acute phase proteins that are important for cattle, as well as explain that acute phase proteins can be used in the early diagnosis of diseases, in the differentiation of viral and bacterial infections, in guiding the treatment of sick animals and in determining their prognosis.

Investigation of Acute Phase Proteins in Cattle Infected with Mycobacterium bovis

“…For this reason, it is stated that Hp concentration can be used in monitoring the immune functions of cattle (Murata and Miyamoto, 1993). In natural and experimental studies, it has been determined that the levels of Hp increase in bacterial, viral and parasitic diseases such as brucella, tuberculosis, alum, Toxocara vitulorum, hypodermosis (Bozukluhan et al, 2016;Merhan et al, 2017). Another important APP in cattle is SAA (Murata et al, 2004).…”

Determination of Levels of Some Acute Phase Proteins, Tumor Necrosis Factor-α, Interleukin-1 and Interleukin-6 in Cattle with Trichophythosis

“…Acute phase proteins (APP) are known as proteins synthesized by the liver in inflammation, infection, tissue damage, neoplastic developments and some immunological diseases (Petersen et al, 2004;Murata et al, 2004;Gökçe and Bozukluhan, 2009). It is important because it is a good marker in the formation of inflammatory process and disease diagnosis, as well as being used in separating clinical diseases from subclinical and in the follow-up of treatment (Bozukluhan and Merhan, 2022;Merhan and Bozukluhan, 2022). The aim of the study is to determine the levels of some APP and proinflammatory cytokines in cattle with trichophytosis.…”