Clinical significance of spontaneous apoptosis in advanced gastric adenocarcinoma

Ikeguchi, Masahide; Cai, Jun; Yamane, Nariyuki; Maeta, Michio; Kaibara, Nobuaki

doi:10.1002/(sici)1097-0142(19990601)85:11<2329::aid-cncr5>3.0.co;2-l

Cited by 27 publications

(13 citation statements)

References 12 publications

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“…Contrary to the results from the current study, there are a few reports that imply a better prognosis for patients with tumors that have higher AI values 26–32. Most of those studies, including the study on patients with squamous carcinoma of the tongue by Xie et al,28 either included patients with tumors in all stages or were restricted to patients with advanced disease.…”

Section: Discussioncontrasting

confidence: 65%

Apoptosis index is a predictor of metastatic phenotype in patients with early stage squamous carcinoma of the tongue

Naresh

Lakshminarayanan

Pai

et al. 2001

Cancer

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BACKGROUND Patients with squamous carcinoma of the oral tongue in clinical stages TIN0M0 and T2N0M0 with a tumor thickness ≤ 3 mm usually do not have lymph node (LN) metastasis. However, factors that are useful in predicting LN metastasis in thicker tumors (> 3 mm thick) need to be identified. The authors investigated the clinical relevance of the apoptotic index (AI), the proliferation index, and tumor grade in relation to LN metastasis in patients with early stage squamous carcinoma of the oral tongue. METHODS Twenty‐three patients with squamous carcinoma of the anterior two‐thirds of the tongue measuring < 2 cm in height and > 3 mm in thickness were evaluated for tumor grade, AI (by using the terminal deoxynucleotidyl transferase‐mediated dUTP nick‐end labeling technique), and proliferation index (by proliferating cell nuclear antigen [PCNA] expression). RESULTS The mean AI value was significantly higher in LN positive patients compared with LN negative patients (P = 0.012). The LN positive and LN negative subgroups did not differ in the mean PCNA index, and there was no significant difference in the distributions of tumor grade between LN positive and LN negative subsets. Four of 12 tumors with an AI ≤ 5% and 10 of 11 tumors with an AI > 5% had LN metastasis (P = 0.009; risk ratio, 20). The AI maintained its significance with respect to LN metastasis in the multivariate analysis (P = 0.003). The 4‐year recurrence free survival was significantly better in patients with tumors that had an AI value ≤ 5% compared with patients with tumors that had an AI > 5% (92% vs. 32%) (P = 0.033). However, the AI lost its impact on recurrence free survival within a Cox proportional hazards model (P = 0.068). CONCLUSIONS A higher AI value is a predictor of LN metastasis and may serve as a prognostic factor in patients with early stage squamous carcinoma of the oral tongue. The authors present a hypothesis to explain this rather surprising finding. Cancer 2001;91:578–84. © 2001 American Cancer Society.

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Section: Discussioncontrasting

confidence: 65%

Apoptosis index is a predictor of metastatic phenotype in patients with early stage squamous carcinoma of the tongue

Naresh

Lakshminarayanan

Pai

et al. 2001

Cancer

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“…There are contradictory data on the relationship between AI and MI. Kupnicka et al 15 and Ikeguchi et al 16 demonstrated a significant correlation between AI and MI in gastric carcinoma, while Lu et al 17 and Shinohara et al 18 found no significant correlations.…”

Section: Discussionmentioning

confidence: 54%

Immunohistochemical Expression of Osteopontin in Gastric Cancer

Imano

Satou

Itoh

et al. 2009

Journal of Gastrointestinal Surgery

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“…1 Derailment of this process plays an important role in the development or growth of malignant tumor and influences host prognosis. [2][3][4][5][6][7] Among the various apoptotic pathways, the Fas (APO-1/CD95) and Fas ligand (FasL) systems play a key function. 8 Despite early diagnosis and improved outcome following a curative resection, a significant number of patients with gastric carcinoma still die due to primary treatment failure or presentation at a late stage of the disease.…”

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confidence: 99%

Prognostic Significance of Fas and Fas Ligand System-Associated Apoptosis in Gastric Cancer

et al. 2000

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Clinical significance of spontaneous apoptosis in advanced gastric adenocarcinoma

Cited by 27 publications

References 12 publications

Apoptosis index is a predictor of metastatic phenotype in patients with early stage squamous carcinoma of the tongue

Apoptosis index is a predictor of metastatic phenotype in patients with early stage squamous carcinoma of the tongue

Immunohistochemical Expression of Osteopontin in Gastric Cancer

Prognostic Significance of Fas and Fas Ligand System-Associated Apoptosis in Gastric Cancer

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