Clinical significance of ST3Gal IV expression in human renal cell carcinoma

Saito, Seiichi; Yamashita, Shinichi; Endoh, Mareyuki; Yamato, Takashi; Hoshi, Senji; Οhyama, Chikara; Watanabe, Ryota; Ito, Akihiro; Satoh, Makoto; Paulson, James C.; Arai, Yoichi; Miyagi, Taeko

doi:10.3892/or.9.6.1251

Cited by 23 publications

(27 citation statements)

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“…Seiichi et al found that increased level of ST3GalII mRNA might be involved not only in carcinogenesis of kidney but also in the malignant progression of human RCC. Down‐regulation of ST3GalIV mRNA was associated with the malignant progression of RCC . In this study, the expression of ST3GalIV mRNA and protein was higher in adjacent noncancerous tissues than that in RCC tissues and RCC cell lines.…”

Section: Discussionmentioning

confidence: 50%

“…The changes of STs are involved in many cancers, such as human hepatic carcinoma and colorectal cancer . It has been reported that the level of ST3GalIV mRNA was decreased in most RCC tissues, and down‐regulation of ST3GalIV mRNA might be one of the factors associated with the malignant progression of human RCC . However, the molecular mechanism and function of ST3GalIV in RCC have not been studied yet.…”

Section: Introductionmentioning

confidence: 99%

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MiR‐193a‐3p and miR‐224 mediate renal cell carcinoma progression by targeting alpha‐2,3‐sialyltransferase IV and the phosphatidylinositol 3 kinase/Akt pathway

Pan

et al. 2018

Molecular Carcinogenesis

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Tumor metastasis is a major cause of cancer-related death in renal cell carcinoma (RCC). MicroRNAs (miRNAs) have been widely known to modulate proliferation invasion, metastasis, and apoptosis of cancer cells. In this study, we aimed to investigate the function and novel target of miR-193a-3p and miR-224 in RCC. The levels of miR-193a-3p and miR-224 were significantly increased in RCC tissues and RCC cell lines. Alpha-2,3-Sialyltransferase IV (ST3GalIV) was highly expressed in adjacent nontumor tissues and human normal proximal tubular cell line HK-2 compared to RCC tissues and cell lines. ST3GalIV expression was negatively correlated with miR-193a-3p and miR-224. Further analysis indicated that miR-193a-3p and miR-224 directly targeted ST3GalIV. MiR-193a-3p and miR-224 increased cell proliferation and migration by directly inhibiting ST3GalIV, and this effect was reversed by co-transfection with ST3GalIV in vitro. Overexpression of miR-193a-3p and miR-224 increased RCC cell proliferation in vivo. Furthermore, the phosphatidylinositol 3 kinase (PI3K)/Akt pathway was mediated by miR-193a-3p and miR-224 in RCC cell lines. Collectively, these results suggested that miR-193a-3p and miR-224 played an important role in regulation of RCC by targeting ST3GalIV via PI3K/Akt pathway.

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Section: Discussionmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 99%

MiR‐193a‐3p and miR‐224 mediate renal cell carcinoma progression by targeting alpha‐2,3‐sialyltransferase IV and the phosphatidylinositol 3 kinase/Akt pathway

Pan

et al. 2018

Molecular Carcinogenesis

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“…The corresponding differences in glycomic maps revealed a substantial increase of fucosylation (both within the core component and the branched segments) with malignant transformation. Interestingly, increased fucosylation has also been associated with pancreatic cancer (33 ), colorectal cancer (40 ), human leukocyte cancer (34 ), and renal carcinomas (35 ). At this point in time, measurements of various sialylated structures in serum present a less clear picture.…”

Section: Discussionmentioning

confidence: 98%

“…Whereas data on glycan modifications in cancer cell lines and tumors, including fucosylation and sialylation, are available (31)(32)(33)(34)(35), it seemed prudent to supplement our investigations on serum glycan levels by the parallel analyses of a human mammary epithelium cell (control) and cancer cell lines (invasive and noninvasive) using the same analytical procedure. Examining the 8 N-glycan structures implicated in the blood serum as pertinent to cancer, we found similar trends for 6 of these structures in the extracts prepared from invasive (MDA-MB-231, MDA-MB-435) and noninvasive (578T, ADR-RES, BT549, T47D) breast cancer cells (Fig.…”

Section: Data Miningmentioning

confidence: 99%

Breast Cancer Diagnosis and Prognosis through Quantitative Measurements of Serum Glycan Profiles

et al. 2008

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“…Fucosylation of glycan structures attached to proteins has been implicated in different types of cancer. Recent results involving pancreatic cancer, 39 colorectal cancer, 40 human leucocyte cancer, 41 hepatocarcinomas, 42 and renal carcinomas 43 all suggest that malignancy is associated with some type of increased fucosylation. Therefore, we can confidently assign the position and linkage of this residue.…”

Section: Ms/ms Of Fucosylated Complex Oligosaccharidesmentioning

confidence: 99%

Laser‐induced photofragmentation of neutral and acidic glycans inside an ion‐trap mass spectrometer

Devakumar

Mechref

Kang

et al. 2007

Rapid Comm Mass Spectrometry

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Permethylated acidic and neutral N-glycans representing different types of glycan structures, such as linear and branched sialylated structures, high-mannose type and fucosylated complex type, were photodissociated with 157 nm vacuum ultraviolet light in a linear ion trap. Cross-ring fragments corresponding to high-energy fragmentation pathways were observed in abundance for all studied structures. Some product ions appear diagnostic for a linkage of sialic acid residues and the glycan antenna to which these residues are attached. A conclusive assignment of the fucosylation site of the studied glycan structure has been facilitated through measurement of cross-ring fragmentation resulting from photodissociation.

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Clinical significance of ST3Gal IV expression in human renal cell carcinoma

Cited by 23 publications

References 0 publications

MiR‐193a‐3p and miR‐224 mediate renal cell carcinoma progression by targeting alpha‐2,3‐sialyltransferase IV and the phosphatidylinositol 3 kinase/Akt pathway

MiR‐193a‐3p and miR‐224 mediate renal cell carcinoma progression by targeting alpha‐2,3‐sialyltransferase IV and the phosphatidylinositol 3 kinase/Akt pathway

Breast Cancer Diagnosis and Prognosis through Quantitative Measurements of Serum Glycan Profiles

Laser‐induced photofragmentation of neutral and acidic glycans inside an ion‐trap mass spectrometer

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