Clinical significance of syndecan-1 and versican expression in human epithelial ovarian cancer

Kusumoto, Tetsuya; Kodama, Junichi; Seki, Nobuhiko; Nakamura, Keiichiro; Hongo, Atsushi; Hiramatsu, Yuji

doi:10.3892/or_00000715

Cited by 36 publications

(9 citation statements)

References 37 publications

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“…In case of ovarian cancer, SDC1 promotes the adhesion and migration of epithelial cells. Thus, SDC1 promotes the transformation in malignancy of ovarian cancer [ 26 , 27 ]. Our results have also shown that upregulated SDC1 in the tissues of ovarian cancer and increased expression of SDC1 are correlational to the bad prognosis in patients of ovarian cancer which was analyzed by our bioinformatical study.…”

Section: Discussionmentioning

confidence: 99%

Integrated Bioinformatics Analysis for Identification of the Hub Genes Linked with Prognosis of Ovarian Cancer Patients

Wang

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. One of the most usual gynecological state of tumor is ovarian cancer and is a major reason of gynecological tumor-related global mortality rate. There have been multiple risk elements related to ovarian cancer like the background of past cases associated with breast cancer or ovarian cancer, or excessive body weight issues, case history of smoking, and untimely menstruation or menopause. Because of unclear expressions, more than 70% of the ovarian cancer patient cases are determined during the early stage. Material and Methods. GSE38666, GSE40595, and GSE66957 were the three microarray datasets which were analyzed using GEO2R for screening the differentially expressed genes. GO, Kyoto Encyclopedia of Genes, and protein expression studies were performed for analysis of hub genes. Then, survival analysis was performed for all the hub genes. Results. From the dataset, a total of 199 differentially expressed genes (DEGs) were identified. Through the KEGG pathway study, it was noted that the DEGs are mainly linked with the AGE-RAGE signaling pathway, central carbon metabolism, and human papillomavirus infection. The survival analysis showed 4 highly expressed hub genes COL4A1, SDC1, CDKN2A, and TOP2A which correlated with overall survival in ovarian cancer patients. Moreover, the expression of the 4 hub genes was validated by the GEPIA database and the Human Protein Atlas. Conclusion. The results have shown that all 4 hub genes were found to be upregulated in ovarian cancer tissues which predict poor prognosis in patients with ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

Integrated Bioinformatics Analysis for Identification of the Hub Genes Linked with Prognosis of Ovarian Cancer Patients

Wang

et al. 2022

Computational and Mathematical Methods in Medicine

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“…A limitation to our in vitro model is the lack of stromal components, which could significantly influence the behavior of the tumor tissue. Ectopic expression of syndecan-1 in stromal cells has been reported in carcinomas of the cervix [95,96], and stromal syndecan-1 expression was shown to correlate with poor prognosis in some tumor types such as cancers of the stomach [97], pancreas [46], endometrium [98], oral cavity [99], breast [100,101], bladder [48], and ovary [102].…”

Section: Discussionmentioning

confidence: 99%

Syndecan-1 Promotes Hepatocyte-Like Differentiation of Hepatoma Cells Targeting Ets-1 and AP-1

et al. 2020

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Syndecan-1 is a transmembrane heparan sulfate proteoglycan which is indispensable in the structural and functional integrity of epithelia. Normal hepatocytes display strong cell surface expression of syndecan-1; however, upon malignant transformation, they may lose it from their cell surfaces. In this study, we demonstrate that re-expression of full-length or ectodomain-deleted syndecan-1 in hepatocellular carcinoma cells downregulates phosphorylation of ERK1/2 and p38, with the truncated form exerting an even stronger effect than the full-length protein. Furthermore, overexpression of syndecan-1 in hepatoma cells is associated with a shift of heparan sulfate structure toward a highly sulfated type specific for normal liver. As a result, cell proliferation and proteolytic shedding of syndecan-1 from the cell surface are restrained, which facilitates redifferentiation of hepatoma cells to a more hepatocyte-like phenotype. Our results highlight the importance of syndecan-1 in the formation and maintenance of differentiated epithelial characteristics in hepatocytes partly via the HGF/ERK/Ets-1 signal transduction pathway. Downregulation of Ets-1 expression alone, however, was not sufficient to replicate the phenotype of syndecan-1 overexpressing cells, indicating the need for additional molecular mechanisms. Accordingly, a reporter gene assay revealed the inhibition of Ets-1 as well as AP-1 transcription factor-induced promoter activation, presumably an effect of the heparan sulfate switch.

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“…Versican Tissues (n = 84) Prognosis for renal carcinoma [72] Tissues (n = 52, 62, 456/453, 89) Prognosis for colon cancer [73,74] Blood (n = 27, 12, 31) Diagnosis for epithelial ovarian cancer [75] Blood (n = 30) Diagnosis for multiple myeloma [76] Tissues (n = 134/104) Prognosis for gastric cancer [77,78] Tissues (n = 142/212) Prognosis for non-small cell lung cancer [79,80] Tissues (n = 50, 19, 31) Diagnosis for hepatocellular carcinoma [81] Tissues (n = 139) Prognosis for oral squamous cell carcinoma [82] Tissues (n = 80/58) Prognosis for breast cancer [83,84] Tissues (n = 111/111) Prognosis for ovarian cancer [85,86] Tissues (n = 167) Prognosis for endometrial cancer [87] Tissues (n = 43) Prognosis for prostate cancer [88] Biglycan Tissues (n = 12,427) Prognosis for prostate cancer [89] Table 2. Cont.…”

Section: Pgsmentioning

confidence: 99%

Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression

Wei

Huang

et al. 2020

IJMS

117

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The extracellular matrix (ECM) spatiotemporally controls cell fate; however, dysregulation of ECM remodeling can lead to tumorigenesis and cancer development by providing favorable conditions for tumor cells. Proteoglycans (PGs) and glycosaminoglycans (GAGs) are the major macromolecules composing ECM. They influence both cell behavior and matrix properties through direct and indirect interactions with various cytokines, growth factors, cell surface receptors, adhesion molecules, enzymes, and glycoproteins within the ECM. The classical features of PGs/GAGs play well-known roles in cancer angiogenesis, proliferation, invasion, and metastasis. Several lines of evidence suggest that PGs/GAGs critically affect broader aspects in cancer initiation and the progression process, including regulation of cell metabolism, serving as a sensor of ECM’s mechanical properties, affecting immune supervision, and participating in therapeutic resistance to various forms of treatment. These functions may be implemented through the characteristics of PGs/GAGs as molecular bridges linking ECM and cells in cell-specific and context-specific manners within the tumor microenvironment (TME). In this review, we intend to present a comprehensive illustration of the ways in which PGs/GAGs participate in and regulate several aspects of tumorigenesis; we put forward a perspective regarding their effects as biomarkers or targets for diagnoses and therapeutic interventions.

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Clinical significance of syndecan-1 and versican expression in human epithelial ovarian cancer

Cited by 36 publications

References 37 publications

Integrated Bioinformatics Analysis for Identification of the Hub Genes Linked with Prognosis of Ovarian Cancer Patients

Integrated Bioinformatics Analysis for Identification of the Hub Genes Linked with Prognosis of Ovarian Cancer Patients

Syndecan-1 Promotes Hepatocyte-Like Differentiation of Hepatoma Cells Targeting Ets-1 and AP-1

Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression

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