Clinical Significance of the Blood Copper in Hodgkin’s Disease

Pagliardi, E; Giangrandi, E

doi:10.1159/000206463

Cited by 44 publications

(9 citation statements)

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“…At the time this was started there had been few studies of the plasma copper in malignancy. Pagliardi and Giangrandi (1960) had reported raised plasma copper levels in Hodgkin's disease, and this was confirmed by Jensen et al (1964). G. S. Andrews Sinha and Gabrieli (1970) reported a raised serum copper in many conditions other than malignancy and considered the change to be of little diagnostic value.…”

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confidence: 92%

Studies of plasma zinc, copper, caeruloplasmin, and growth hormone

Andrews

1979

J Clin Pathol

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SUMMARY The levels of plasma zinc, copper, caeruloplasmin, and growth hormone were determined in a group of normal people and in four groups of patients who were suffering from carcinoma of the bronchus, other forms of malignancy, chest illnesses, and diseases other than chest illness or malignancy. The plasma zinc was higher, and the plasma copper lower, in people without malignancy below the age of 30 years than they were in other age groups.It was confirmed that about 66 % of patients with carcinoma of the bronchus had plasma zinc levels less than 11 5 pmol/l but low levels were also found in 23 % of other cases of malignancy and in 9 % of the other patients. In carcinoma of the bronchus the low plasma zinc was found to be associated with epidermoid and anaplastic tumours and was to some extent related to the duration of the disease. In carcinoma of the bronchus the plasma copper was found to be higher than in all other groups, and values higher than 26&5 Atmol/l were considered to support a diagnosis of carcinoma of the bronchus. There was, however, no relationship between the increase in the plasma copper and the decrease in the plasma zinc. Raised caeruloplasmin levels above 420 mg/l were found in 65% of cases of carcinoma of the bronchus, and these high levels were usually associated with raised plasma copper. Growth hormone was normal in all groups except six patients with carcinoma of the bronchus with secondary carcinoma of the liver, in whom it was raised. Surgical operations lowered plasma zinc and raised growth hormone but did not affect plasma copper.

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confidence: 92%

Studies of plasma zinc, copper, caeruloplasmin, and growth hormone

Andrews

1979

J Clin Pathol

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“…and copper 22 > 25 > 28 . 29 > 30 , this latter being most likely related to the non-ceruloplasmin fraction 15 .…”

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confidence: 96%

Bioquímica dos meningiomas: conteúdo de cobre, ceruloplasmina, magnésio e enxofre no soro sanguíneo, e conteúdo de cálcio, fósforo, cobre, magnésio, sódio e potássio no tecido tumoral

Canelas

Jorge

Tenuto

et al. 1970

Arq. Neuro-Psiquiatr.

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A series of investigations has evidenced, in the blood serum of patients with several types of neoplasms, an increase of the concentrations of sulfur 15 . 16 1 , comparing the composition of a spongioblastoma with the normal grey matter, found higher values of K, lower values of Mg and P, and similar levels of Na. Higher concentrations of Ca were found in two-thirds of 25 gliomas studied by Wender and Hierowski 32 ; in 60 per cent of the cases Na was increased, while K was lowered; in a third of cases, however, K levels were higher than in normal brain tissue. Studying the Taiochemistry of 9 astrocytomas, 10 glioblastomas and 10 medulloblastomas as compared to the normal brain tissue, Canelas et al. 6 found higher contents of Ca, Cu and Mg, irrespective of the histological pattern; the levels of Na were higher in astrocytomas and glioblastomas, K showed a trend to higher levels in astrocytomas, and the values of P were higher in glioblastomas and medulloblastomas.In a survey of the literature on meningiomas we have only found studies on some organic components of the tumors, such as fatty acids, phospholipides, lipides in general, and mucopolysaccharides.A study has been made of Cu, ceruloplasmin, Mg and S contents in the blood serum of patients with meningiomas, as well as of Cu, Mg, Ca, P, K and Na concentrations in the tumor itself. The results were compared with the normal values in the serum and in the dura mater (it is well

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“…Remarkably, the homeostatic balance of bioavailable copper is metastable and of evident importance, in that a number of tissue abnormalities and disease states in humans have been associated with either reduced or elevated levels of copper (2). Serum copper levels are elevated in cancer patients and correlate with the severity of the disease and response to therapies (3,4). In animal models, copperchelating drugs have been reported to have antiangiogenic activity (5)(6)(7)(8).…”

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confidence: 99%

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

Ishida

Andreux²,

Poitry‐Yamate

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

336

257

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Significance This paper describes the mechanism by which copper mediates the interplay between the two energy-producing pathways, respiration and glycolysis. Many tumors produce increased levels of lactate, even when oxygen abounds, reflecting aerobic glycolysis (“Warburg effect”), whereas most normal tissues solely use respiration. We demonstrate that reducing systemic copper with a chelating drug impaired mitochondrial energy metabolism and decreased ATP levels despite induction of glycolysis. We propose that the metabolic phenotype of tumors is modulated in part by variable levels of copper in tumor microenvironment. Our work identifies copper as a tumor promoter by demonstrating that chronic exposure to elevated levels of copper in drinking water—to the maximum allowed in public water supplies—accelerates tumor growth in mice.

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Clinical Significance of the Blood Copper in Hodgkin’s Disease

Cited by 44 publications

References 1 publication

Studies of plasma zinc, copper, caeruloplasmin, and growth hormone

Studies of plasma zinc, copper, caeruloplasmin, and growth hormone

Bioquímica dos meningiomas: conteúdo de cobre, ceruloplasmina, magnésio e enxofre no soro sanguíneo, e conteúdo de cálcio, fósforo, cobre, magnésio, sódio e potássio no tecido tumoral

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

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