Clinical Significance of the Cholesterol Partition of the Blood Plasma in Hepatic and in Biliary Diseases

The Lipids of Serum and Liver in Patients With Hepatic Diseases 1

“…Neutral fat is, however, high in biliary obstruction and in infectious hepatitis, as compared with cirrhosis and toxic hepatitis in which it is usually comparatively low. From Figures 4 and 5, it will be seen that in both biliary obstruction and in some cases of infectious hepatitis neutral fat rises, to fall again as the obstruction is relieved or the icterus sub- The interrelationships of the serum lipids It has been reported repeatedly that the ratio of free to total cholesterol is frequently elevated in hepatic disease (8,9). Published data have, however, been obtained almost entirely by colorimetric procedures that yield higher and more variable ratios than does the digitonin method employed for the present study.…”

“…The degree of hypercholesterolemia in this and other series cannot, however, be correlated with the duration of the jaundice. This has led certain observers (8) to conclude that ultimately, if the obstruction is not relieved, cholesterol will again diminish, sometimes to subnormal concentrations. The features which determine the course of the hypercholesterolemia do not seem to be quite so simple as this.…”

Effect of Disease of the Liver and Biliary Tract Upon the Phosphatase Activity of the Serum

“…MFay 20,1937 June 14, 1937 November 13,1936 April 20, 1938 Way 16, 1938 August 11,1938 December 2, 1936 December 22, 1936 November 22, 1937 December 1, 1937 May 31, 1938 January 13, 1937 January 12, 1937 January 20, 1937 March 24, 1939 March 31, 1939 January 27, 1939 February 15, 1939 March 14,1939 October 28, 1938 November 28,1938 December 15, 1938 January 25, 1939 …”

Value of Single-sample Test in Differential Diagnosis of Jaundice

“…This value of 300 mg. per 100 ml. was the level above which Epstein and Greenspan (1936) considered significant hypercholesterolaemia to be present. They found that this level was exceeded by 78% of their cases of obstructive jaundice, while only 10% of their cases of hepatogenous jaundice showed hypercholesterolaemia.…”