Clinical significance of the determination of surfactant proteins A and D in assessing the activity of lung sarcoidosis

Beketov, Vladimir; Lebedeva, Marina; Мухин, Н А; Serova, Anna; Ponomarev, A B; Попова, Е. Н.; Yanakaeva, Alisa; Solomka, V A; Kondrashov, Alexander; Konovalov, D. V.

doi:10.26442/terarkh201890342-46

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…It has been reported that SP-D correlates with the severity of interstitial lung disease [ 40 ] and in our study, there is a statistically significant correlation between SP-D concentrations and disease extent. Other studies have demonstrated possible prognostic implications, with serum concentrations of SP-D corresponding to worsening DLCO% and HRCT evidence of progression of sarcoidosis pulmonary fibrosis [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation of the High-Resolution Computed Tomography Patterns of Intrathoracic Sarcoidosis with Serum Levels of SAA, CA 15.3, SP-D, and Other Biomarkers of Interstitial Lung Disease

Leštan Ramovš,

Sodin-Šemrl,

Lakota

et al. 2023

IJMS

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Studies on the serum biomarkers of granulomatous inflammation and pulmonary interstitial disease in intrathoracic sarcoidosis have shown conflicting results. We postulated that differences in the concentrations of serum biomarkers can be explained by the heterogenous patterns of sarcoidosis seen on thoracic HRCT. Serum biomarker levels in 79 consecutive patients, newly diagnosed with intrathoracic sarcoidosis, were compared to our control group of 56 healthy blood donors. An analysis was performed with respect to HRCT characteristics (the presence of lymph node enlargement, perilymphatic or peribronchovascular infiltrates, ground-glass lesions, or fibrosis), CXR, and disease extent. Serum levels of CXCL9, CXCL10, CTO, and CCL18 were statistically significantly increased in all patients compared to controls. Serum levels of CA15.3 were statistically significantly increased in all patients with parenchymal involvement. SAA was increased in patients with ground-glass lesions while SP-D levels were statistically significantly increased in patients with lung fibrosis. Only SP-D and CA15.3 showed a significant correlation to interstitial disease extent. In conclusion, we found that sarcoidosis patients with different HRCT patterns of intrathoracic sarcoidosis have underlying biochemical differences in their serum biomarkers transcending Scadding stages. The stratification of patients based on both radiologic and biochemical characteristics could enable more homogenous patient selection for further prognostic studies.

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Section: Discussionmentioning

confidence: 99%

Correlation of the High-Resolution Computed Tomography Patterns of Intrathoracic Sarcoidosis with Serum Levels of SAA, CA 15.3, SP-D, and Other Biomarkers of Interstitial Lung Disease

Leštan Ramovš,

Sodin-Šemrl,

Lakota

et al. 2023

IJMS

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“…Beketov et al found that patient progression of sarcoidosis significantly correlated with serum SP-D levels (P<0.05). 35…”

Section: Krebs Von Den Lungen-6 (Kl-6) and Surfactant-d As Biomarkers...mentioning

confidence: 99%

Krebs von den Lungen-6 (KL-6) and Surfactant-D as Biomarkers of Interstitial Lung Disease: A Literature Review

Fachrucha,

Fadhillah,

Aflah

2024

J Respirol Indones

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Interstitial Lung Disease (ILD) is a group of lung diseases characterized by various patterns of lung tissue damage, including inflammation and fibrosis of the lung interstitium, both with known or unknown causes (idiopathic). In establishing the diagnosis of ILD, a comprehensive approach including history-taking, physical examination, and supporting examinations, is needed and managed in a multidisciplinary manner. Biomarkers are diagnostic tools known to be accessible, inexpensive, reproducible, and non-invasive for helping diagnose ILD patients. Growing evidence has supported the idea that many biomarker molecules can detect lung injury in ILD, including Krebs von de lungen-6 (KL-6) and Surfactant D (SP-D). KL-6 and SP-D could be utilized in the detection, disease monitoring, prognostication, and therapeutic responses of ILD patients. This review aimed to discuss several potential Kl-6 and SP-D biomarkers against ILD and discusses their clinical utility.

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SP-A and SP-D surfactant proteins and conventional risk factors for chronic non-infectious human diseases

Nikolaev,

Kharlamova,

Kosarev

et al. 2023

Sibirskij nauchnyj medicinskij zhurnal

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Surfactant proteins SP-A and SP-D, which belong to the family of collagen-containing type C lectins, are used as diagnostic and prognostic markers for many acute and chronic respiratory diseases. The aim of the study is to assess the impact of conventional risk factors for chronic non-infectious diseases on SP-A and SP-D protein levels by means of systemic and structural analysis on the basis of relevant publications from international databases and official WHO reports. This analytical review concludes that widespread expression of SP-A and SP-D is documented in numerous studies, and, although the lungs remain the main site of synthesis of surfactant proteins, one can expect its significant impact on the immune and inflammatory response in many organs and tissues. The authors note that there are several known extrapulmonary effects of these proteins. However, many mechanisms of additional cellular effects of SP-A and SP-D outside the bronchopulmonary system still remain unstudied, which indicates the prospects for further research in this area.

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Clinical significance of the determination of surfactant proteins A and D in assessing the activity of lung sarcoidosis

Cited by 5 publications

References 7 publications

Correlation of the High-Resolution Computed Tomography Patterns of Intrathoracic Sarcoidosis with Serum Levels of SAA, CA 15.3, SP-D, and Other Biomarkers of Interstitial Lung Disease

Correlation of the High-Resolution Computed Tomography Patterns of Intrathoracic Sarcoidosis with Serum Levels of SAA, CA 15.3, SP-D, and Other Biomarkers of Interstitial Lung Disease

Krebs von den Lungen-6 (KL-6) and Surfactant-D as Biomarkers of Interstitial Lung Disease: A Literature Review

SP-A and SP-D surfactant proteins and conventional risk factors for chronic non-infectious human diseases

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