Clinical significance of the fucosyltransferase 2 (FUT2) secretor status in children hospitalized with acute gastroenteritis in Taiwan

Lin, Hsin-Yeh; Lai, Hsin-Chih; Chen, Ying Fang Elaine; Chao, Hsun-Ching; Tsai, Chun‐Yi; Chang, Yi-Jung; Chen, Shih-Yen

doi:10.1016/j.jfma.2020.04.017

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…Payne et al [34] additionally found that non-secretor status could act as a protective mechanism against severe rotavirus gastroenteritis. Consistent with this, patients with the secretor phenotype were shown to be associated with a greater risk of infection transmission and disease severity, including prolonged diarrhea and frequent vomiting [36].…”

Section: Secretor Status and Gastroenteritissupporting

confidence: 55%

The Combined Effect of Infant and Mother Secretor Status on Infant Susceptibility to Viral Gastroenteritis and Celiac Disease

Das¹,

Murphy²,

Goldman³

2023

Recent Prog Nutr

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Celiac disease is a prevalent autoimmune disorder with a rising incidence of 7.5% annually during the second half of the 20th century and the 21st century. Not all genetically susceptible individuals that carry the risk alleles HLA DQ2 and DQ8 go on to develop celiac disease, suggesting that there may be other environmental triggers that contribute to the development of celiac disease in genetically susceptible individuals. Gastroenteritis during infancy has been shown to be associated with increased risk of celiac disease. Secretor status, per the FUT2 genotype, and subsequent alterations in the microbiota, is associated with risk of gastroenteritis in infants. This review investigates the literature from January 2010 to June 2022 to determine the combined effect of secretor status and viral gastroenteritis on the development of celiac disease. Mothers with the secretor phenotype and infants with the non-secretor phenotype provided the most protection against particular strains of gastroenteritis and celiac disease. Both the maternal and infant secretor status, as well as the infant’s Lewis status and ABO blood group can influence the infant’s susceptibility to different viral strains, which cause gastroenteritis. Gastroenteritis caused by viral infections can damage intestinal epithelial cells, cause dysbiosis, and affect pro-inflammatory cytokines, which exacerbate celiac disease onset. Understanding the effect of secretor status and gastroenteritis on celiac disease may provide a novel approach to early screening and preventative strategies to reduce risk factors that contribute to the onset of celiac disease.

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Section: Secretor Status and Gastroenteritissupporting

confidence: 55%

The Combined Effect of Infant and Mother Secretor Status on Infant Susceptibility to Viral Gastroenteritis and Celiac Disease

Das¹,

Murphy²,

Goldman³

2023

Recent Prog Nutr

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“…Infection may persist for longer in young children [110]. Secretor positive children with norovirus AGE present more severe symptoms than children with non-norovirus AGE [111][112][113][114]. Vomiting is a primary symptom in children seeking medical care for human norovirus AGE [115], sometimes with intensities indistinguishable from rotavirus infections.…”

Section: Norovirus Burden Of Diseasementioning

confidence: 99%

Serological Humoral Immunity Following Natural Infection of Children with High Burden Gastrointestinal Viruses

Zweigart

Becker‐Dreps

Bucardo

et al. 2021

Viruses

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Acute gastroenteritis (AGE) is a major cause of morbidity and mortality worldwide, resulting in an estimated 440,571 deaths of children under age 5 annually. Rotavirus, norovirus, and sapovirus are leading causes of childhood AGE. A successful rotavirus vaccine has reduced rotavirus hospitalizations by more than 50%. Using rotavirus as a guide, elucidating the determinants, breath, and duration of serological antibody immunity to AGE viruses, as well as host genetic factors that define susceptibility is essential for informing development of future vaccines and improving current vaccine candidates. Here, we summarize the current knowledge of disease burden and serological antibody immunity following natural infection to inform further vaccine development for these three high-burden viruses.

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“…The reasons for this are unknown, but they could be related to several causes, including microbiota diversity, which would also comprise HBGA-expressing bacteria, differences between GII.4 variants, general health status, weak-secretor phenotype, or other unidentified host factors. Interestingly, Lin et al described that secretor patients have prolonged diarrhea, more frequent vomiting, more severe disease, and greater infection transmissibility than non-secretors [60].…”

Section: Hbgas and Novmentioning

confidence: 99%

The Role of Host Glycobiology and Gut Microbiota in Rotavirus and Norovirus Infection, an Update

Peña-Gil

Santiso-Bellón

Gozalbo-Rovira

et al. 2021

IJMS

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Rotavirus (RV) and norovirus (NoV) are the leading causes of acute gastroenteritis (AGE) worldwide. Several studies have demonstrated that histo-blood group antigens (HBGAs) have a role in NoV and RV infections since their presence on the gut epithelial surfaces is essential for the susceptibility to many NoV and RV genotypes. Polymorphisms in genes that code for enzymes required for HBGAs synthesis lead to secretor or non-secretor and Lewis positive or Lewis negative individuals. While secretor individuals appear to be more susceptible to RV infections, regarding NoVs infections, there are too many discrepancies that prevent the ability to draw conclusions. A second factor that influences enteric viral infections is the gut microbiota of the host. In vitro and animal studies have determined that the gut microbiota limits, but in some cases enhances enteric viral infection. The ways that microbiota can enhance NoV or RV infection include virion stabilization and promotion of virus attachment to host cells, whereas experiments with microbiota-depleted and germ-free animals point to immunoregulation as the mechanism by which the microbiota restrict infection. Human trials with live, attenuated RV vaccines and analysis of the microbiota in responder and non-responder individuals also allowed the identification of bacterial taxa linked to vaccine efficacy. As more information is gained on the complex relationships that are established between the host (glycobiology and immune system), the gut microbiota and intestinal viruses, new avenues will open for the development of novel anti-NoV and anti-RV therapies.

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Clinical significance of the fucosyltransferase 2 (FUT2) secretor status in children hospitalized with acute gastroenteritis in Taiwan

Cited by 7 publications

References 20 publications

The Combined Effect of Infant and Mother Secretor Status on Infant Susceptibility to Viral Gastroenteritis and Celiac Disease

The Combined Effect of Infant and Mother Secretor Status on Infant Susceptibility to Viral Gastroenteritis and Celiac Disease

Serological Humoral Immunity Following Natural Infection of Children with High Burden Gastrointestinal Viruses

The Role of Host Glycobiology and Gut Microbiota in Rotavirus and Norovirus Infection, an Update

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