Clinical significance of total and lipid bound sialic acid levels in oral pre‐cancerous conditions and oral cancer

Rajpura, Kinnari B.; Patel, Prabhudas S.; Chawda, Jyoti; Shah, Raksha

doi:10.1111/j.1600-0714.2004.00210.x

Cited by 48 publications

(48 citation statements)

References 19 publications

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“…Serum Sialic acid is associated with incremental features of the metabolic syndrome. It should be highlighted that elevated serum sialic acid concentrations are not specific for CVD several malignancies compared to controls such as oral cancer [22], intraocular melanoma [23], laryngeal cancer [24], cholangio carcinoma [25] and is elevated in colorectal cancer [26]. Serum total sialic acid levels markedly elevated in alcoholism [27,28] and is significantly elevated in inflammatory diseases such as liver cirrhosis [29].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Sialic acid Levels in Patients with Type 2 Diabetes Mellitus

Mahendran¹,

Kumar²

2013

IOSR-JDMS

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Section: Discussionmentioning

confidence: 99%

Evaluation of Sialic acid Levels in Patients with Type 2 Diabetes Mellitus

Mahendran¹,

Kumar²

2013

IOSR-JDMS

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“…Aberrant glycosylation of cell surface glycoproteins has been observed for tumor cells and its involvement in the metastatic processes (34). The human body stimulates the synthesis of glycoproteins in the liver associated with malignant transformations, which subsequently enter into the circulation (35). The decreased the levels of erythrocyte membrane glycoprotein may be due to the increased membrane degradation (36).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of chemopreventive effects of Thymoquinone on cell surface glycoconjugates and cytokeratin expression during DMBA induced hamster buccal pouch carcinogenesis

Rajkamal¹,

Suresh²,

Govindasamy³

et al. 2010

BMB Reports

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The present study aimed to investigate the membrane stabilizing effect of Thymoquinone (TQ) on cell surface glycoconjugates and cytokeratin expression against DMBA induced hamster buccal pouch carcinogenesis. 0.5% DMBA painting (three times per week) in hamster buccal pouches for 14 weeks resulted in the formation of well developed oral squamous cell carcinoma. We observed 100% tumor formation with marked abnormalities of glycoconjugates status in tumor bearing hamsters as compared to control animals. Oral administration of TQ at a dose of 30 mg/kg body weight, to DMBA painted hamsters on alternate days for 14 weeks, reduced the tumor formation as well as protected the levels of cell surface glycoconjugates in DMBA painted hamsters. The present study thus suggests that TQ has potent chemopreventive efficacy as well as protected the abnormalities on cell surface glycoconjugates during DMBA induced hamster buccal pouch carcinogenesis [BMB reports 2010; 43(10): 664-669]

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“…Elevated levels of glycoconjugates due to biochemical changes in cell surface glycoproteins and glycolipids have been observed during malignant transformation (16,17). The elevated levels of hexose and hexosamine in group II patients of the present study (Table 1) might be a consequence of tissue necrosis caused by rapidly spreading tumor cell, destructing normal surrounding connective tissue.…”

Section: Discussionmentioning

confidence: 65%

Effect of vitamin E on protein bound carbhohydrate complexes in radiation treated oral squamous cell carcinoma patients

Chitra

Devi

2008

Indian J Clin Biochem

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Serum glycoproteins were evaluated in oral squamous cell carcinoma patients treated with radiotherapy and also the effect of vitamin E was studied. Cell surface glycoconjugates are important parameters in the detection of malignancy. Thus, the objective of the present study is to evaluate the efficacy of vitamin E on glycoproteins in oral cavity cancer patients treated with radiotherapy. The study includes 26 age and sex matched normal healthy individuals and 26 patients with squamous cell carcinoma of oral cavity. These patients were divided into two groups, one for radiotherapy alone (at a dosage of 6000 cGy in five fractions per week for a period of six weeks) and the other for radiotherapy plus vitamin E supplementation (at a dosage of 400 IU / day of vitamin E) for the entire period of radiotherapy. Levels of hexose, hexosamine, fucose and sialic acid were increased in oral squamous cell carcinoma patients and a significant decrease was observed in radiation treated patients when compared to control. The levels of glycoconjugates were significantly decreased in radiation treated patients supplemented with vitamin E. This measurement may be useful in assessing disease progression and identifying patients resistant to therapy and a possible role of vitamin E on reduction in glycoconjugate levels of radiation treated oral squamous cell carcinoma patients.

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Clinical significance of total and lipid bound sialic acid levels in oral pre‐cancerous conditions and oral cancer

Abstract: The data revealed significant elevations in sialic acid levels in oral cancer patients and suggested potential utility of these parameters in diagnosis as well as determining clinical stage of the malignant disease.

Cited by 48 publications

References 19 publications

Evaluation of Sialic acid Levels in Patients with Type 2 Diabetes Mellitus

Evaluation of Sialic acid Levels in Patients with Type 2 Diabetes Mellitus

Evaluation of chemopreventive effects of Thymoquinone on cell surface glycoconjugates and cytokeratin expression during DMBA induced hamster buccal pouch carcinogenesis

Effect of vitamin E on protein bound carbhohydrate complexes in radiation treated oral squamous cell carcinoma patients

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