Clinical Significance of Transient Asymptomatic Elevations in Aminotransferase (TAEAT) in Oncology

Lewis, James H.; Khaldoyanidi, Sophia; Britten, Carolyn D.; Wei, Andrew H.; Subklewe, Marion

doi:10.1097/coc.0000000000000932

Cited by 6 publications

(2 citation statements)

References 127 publications

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“…Hy's law criteria have been historically useful for predicting serious drug-induced hepatocellular liver injury, with approximately 1 in 10 Hy law cases leading to death from liver-related causes or the need for liver transplant [43,44,45]. The detection of ≥2 Hy law cases in DILI-HILI is a strong predictor of significant risk and may prevent further development [45][46][47][48][49][50][51].…”

Section: Pathophysiology Of Hili Resulting Frommentioning

confidence: 99%

Green Tea Consumption Is Increasing but There Are Significant Hepatic Side Effects

2022

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Herbal medicines including teas and plant extracts have been in use for thousands of years. There are reports of the use of herbal preparations in Egypt, China, India, and Samaria. Many patients consider “natural” herbal teas to be completely free of unwanted side effects. Many herbal products, however, have biological activities that can result in severe hepatic cell toxicity or interact with other herbal products or prescription medications. Their use is increased dramatically. The most common herbal teas and nonmineral natural products are used as self-medication, principally for health improvement. However, these products are potentially dangerous to some individuals. Monitoring for liver injury is an important aspect of drug and herbal safety assessment. When present, herbal-induced liver injury (HILI) may limit the use or result in the discontinuation of these agents. HILI can exhibit with a wide spectrum of clinical and laboratory manifestations, ranging from asymptomatic elevations in aminotransferases to acute liver failure. Most cases of HILI resolve within several weeks after herbal remedy discontinuation. However, some cases can persist as low-level aminotransferase elevations. Our review aims to (1) describe the possible significant discrepancies between the ingredients listed on the label and the actual contents of the preparation; (2) evaluate teas containing multiple plants or herbs which may be adulterated by more toxic herbs, heavy metals, microbials, pharmaceuticals, and medicines; (3) describe pathophysiologic events in herbal tea-induced hepatotoxicity; and (4) discuss the key elements required for attributing the consumption of tea to the induction of liver injury. The widespread use of mixed heterogeneous remedies and the lack of randomized trials are an obstacle to providing safe use of plant-derived teas.

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Section: Pathophysiology Of Hili Resulting Frommentioning

confidence: 99%

Green Tea Consumption Is Increasing but There Are Significant Hepatic Side Effects

2022

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“…For the time being, the determination of ALT and AST activities and their ratio (de Ritis index) remains relevant. In recent years, these indicators have been used to predict the likelihood of death in patients with coronavirus disease [3], malignant processes with metastases [4,5], the development of systemic pathologies (atherosclerosis, type 2 diabetes, coronary heart disease, metabolic syndrome) [2,6,7]. Normally, the activity of aminotransferases is genetically determined and varies depending on the age and gender.…”

Section: Introductionmentioning

confidence: 99%

Application of sensor structures based on a photoelectric transducer to determine the activity of aspartate and alanine aminotransferases in blood plasma

Kozinetz

Tsymbalyuk

Litvinenko

2023

Biomed. Phys. Eng. Express

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The application of a recombination sensor for the detection of transaminase activities (ALT/AST) in the blood plasma of rats in real time has been demonstrated. The parameter that is directly measured in real time is the photocurrent through the structure with buried silicon barrier when light with high absorption coefficient is used. Detection can be realized as a result of specific chemical reactions catalyzed by ALT and AST enzymes (α-ketoglutarate + aspartate and α-ketoglutarate + alanine). The change of the effective charge of the reagents allows recording the activity of enzymes from photocurrent measurements. The main factor in this approach is the influence on the parameters of the recombination centers at the interface. The physical mechanism of the sensor structure can be explained within the framework of the Stevenson theory, taking into account the changes in the pre surface band bending, the capture cross sections and the energy position of the recombination levels during adsorption. The paper also offers theoretical analyze allowing optimization of analytical signals of recombination sensor. A promising approach to develop simple and sensitive method for the detection of transaminases activity in real time scale is proposed.

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Building analytical models for predicting de novo malignancy in pancreas transplant patients: A machine learning approach

Zadeh,

Broach,

Nosoudi

et al. 2024

Expert Systems with Applications

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Clinical Significance of Transient Asymptomatic Elevations in Aminotransferase (TAEAT) in Oncology

Cited by 6 publications

References 127 publications

Green Tea Consumption Is Increasing but There Are Significant Hepatic Side Effects

Green Tea Consumption Is Increasing but There Are Significant Hepatic Side Effects

Application of sensor structures based on a photoelectric transducer to determine the activity of aspartate and alanine aminotransferases in blood plasma

Building analytical models for predicting de novo malignancy in pancreas transplant patients: A machine learning approach

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